Reaction Details Report a problem with these data
Target
Beta-secretase 2 [21-466]
Ligand
BDBM238984
Substrate
n/a
Meas. Tech.
Cell-Free Assay
pH
4.5000±n/a
Temperature
310.1500±n/a K
IC50
2260±n/a nM
Comments
extracted
Citation
 Brodney, MA; O'Neill, BT; Butler, CR; LaChapelle, EA Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds US Patent  US9403846 Publication Date 8/2/2016 
Target
Name:
Beta-secretase 2 [21-466]
Synonyms:
BACE2_HUMAN | BACE2 | AEPLC | ALP56 | ASP21 | Beta-secretase 2
Type:
Enzyme
Mol. Mass.:
47922.64
Organism:
Human
Description:
amino acid: 21-466
Residue:
446
Sequence:
APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEP
  
Inhibitor
Name:
BDBM238984
Synonyms:
US9403846, 2
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: