Target
Angiopoietin-1 receptor [776-1124]
Ligand
BDBM239579
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
0.4±n/a nM
Comments
extracted
Citation
 Süβmeier, FLobell, MGrünewald, SHärter, MBuchmann, BTelser, JJöriβen, HHeroult, MKahnert, ALustig, KLindner, N Substituted phenylimidazopyrazoles and their use US Patent  US9394309 Publication Date 7/19/2016 
Target
Name:
Angiopoietin-1 receptor [776-1124]
Synonyms:
TEK | TIE2 | TIE2_HUMAN | Tyrosine-protein kinase receptor TIE-2 | VMCM | VMCM1
Type:
Enzyme
Mol. Mass.:
39865.58
Organism:
Homo sapiens (Human)
Description:
amino acids 776-1124
Residue:
349
Sequence:
NVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
  
Inhibitor
Name:
BDBM239579
Synonyms:
US9394309, 32
Type:
Small organic molecule
Emp. Form.:
C27H24F5N5O2S
Mol. Mass.:
577.569
SMILES:
Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(cc12)-c1cccnc1
Structure:
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