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Target
SUMO-activating enzyme subunit 1/2
Ligand
BDBM791565
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
>200±n/a nM
Citation
 XIE, Y; WU, Y; QIAN, L COMPOUNDS AS SUMO ACTIVATING ENZYME INHIBITORS US Patent  US20260035382 Publication Date 2/5/2026
Target
Name:
SUMO-activating enzyme subunit 1/2
Synonyms:
SUMO E1 | SUMO-activating enzyme
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 977623
Components:
This complex has 2 components.
Component 1
Name:
SUMO-activating enzyme subunit 2
Synonyms:
Ubiquitin-like 1-activating enzyme E1B | Ubiquitin-like modifier-activating enzyme 2 | SUMO-activating enzyme subunit 2 | Anthracycline-associated resistance ARX | 6.3.2.- | SAE2_HUMAN | UBA2 | SAE2 | UBLE1B | SUMO-activating enzyme subunit 2 (SAE2)
Type:
Enzyme
Mol. Mass.:
71206.17
Organism:
Human
Description:
Q9UBT2
Residue:
640
Sequence:
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
  
Component 2
Name:
SUMO-activating enzyme subunit 1
Synonyms:
SUMO-activating enzyme subunit 1 (SAE1) | SAE1_HUMAN | SAE1 | AOS1 | SUA1 | UBLE1A | SUMO1 activating enzyme subunit 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Human
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
  
Inhibitor
Name:
BDBM791565
Synonyms:
US20260035382, Compound 263
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCN1Cc2sc(C(=O)c3cncnc3N[C@@H]3C[C@H](COS(N)(=O)=O)[C@@H](O)C3)cc2[C@@]2(C1)OCCc1ccc(F)cc12
Structure:
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