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Target
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
Ligand
BDBM240771
Substrate
n/a
Meas. Tech.
Activation Assay
pH
7.0000±n/a
Temperature
298.1500±n/a K
EC50
37±n/a nM
Comments
extracted
Citation
 Langkopf, E; Blum, A Azabenzimidazole derivatives US Patent  US9422312 Publication Date 8/23/2016 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
Synonyms:
5'-AMP-activated protein kinase catalytic subunit alpha-1/beta-1/gamma-1 | 5'-AMP-activated protein kinase Complex 1 | Adenosine monophosphate-activated protein kinase (AMPK gamma 1, beta 1 and alpha 1) | AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 | AMPK alpha1/beta1/gamma1 | AMPK complex 1 (alpha-1,beta-1,gamma-1) | Recombinant AMPK alpha1/beta1/gamma1 complex
Type:
n/a
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 0 components.
Component 1
Name:
5'-AMP-activated protein kinase subunit beta-1
Synonyms:
AMPKb | 5''''-AMP-activated protein kinase subunit beta-1 | AMPK subunit beta-1 | 5'-AMP-activated protein kinase subunit beta-1 | AMP-activated protein kinase alpha-2/beta-1/gamma-3 | AAKB1_HUMAN | 5''-AMP-activated protein kinase subunit beta-1 | AMPK | PRKAB1
Type:
n/a
Mol. Mass.:
30380.94
Organism:
Human
Description:
Q9Y478
Residue:
270
Sequence:
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
  
Component 2
Name:
5'-AMP-activated protein kinase subunit gamma-1
Synonyms:
AAKG1_HUMAN | AMPK gamma1 | AMPK gamma-1 | AMPKg | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | 5''''-AMP-activated protein kinase subunit gamma-1 | AMP-activated protein kinase, gamma-1 subunit | AMPK alpha2/beta2/gamma1 | 5''-AMP-activated protein kinase subunit gamma-1 | AMPK subunit gamma-1
Type:
n/a
Mol. Mass.:
37581.44
Organism:
Human
Description:
P54619
Residue:
331
Sequence:
METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP
  
Component 3
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms:
AMP-activated protein kinase, alpha-1 subunit | AMPK-alpha1 | AMPK subunit alpha-1 | ACACA kinase | Hydroxymethylglutaryl-CoA reductase kinase | Tau-protein kinase PRKAA1 | AAPK1_HUMAN | PRKAA1 | AMPK1 | AMP-activated protein kinase alpha-1/beta-2/gamma-2
Type:
Protein
Mol. Mass.:
64023.62
Organism:
Human
Description:
Q13131
Residue:
559
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
  
Inhibitor
Name:
BDBM240771
Synonyms:
US9422312, 7
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: