Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM248142
Substrate
n/a
Meas. Tech.
CA Inhibition Assay
pH
7.5000±n/a
Temperature
298.1500±n/a K
Ki
5.1e+2±n/a nM
Comments
extracted
Citation
 Durdagi, S; Scozzafava, G; Vullo, D; Sahin, H; Kolayli, S; Supuran, CT Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies. J Enzyme Inhib Med Chem 29:469-75 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) | CA-IV | Carbonate dehydratase IV | CAH4_HUMAN | CA4 | Carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Human
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM248142
Synonyms:
Grayanotoxin III (GTX3)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: