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Target
Carbonate dehydratase
Ligand
BDBM10880
Substrate
n/a
Meas. Tech.
ChEMBL_158308 (CHEMBL763365)
pH
7.5000±0.0000
Temperature
293.1500±0.0000 K
Ki
27±0 nM
Km
1600000.0000±0.0000 nM
Citation
 Del Prete, S; Vullo, D; De Luca, V; Carginale, V; di Fonzo, P; Osman, SM; AlOthman, Z; Supuran, CT; Capasso, C Anion inhibition profiles of a-, ß- and ¿-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. Bioorg Med Chem 24:3413-7 (2016) [PubMed]  Article 
Target
Name:
Carbonate dehydratase
Synonyms:
Beta-carbonic anhydrase | PgiCAb
Type:
Protein
Mol. Mass.:
26160.23
Organism:
Porphyromonas gingivalis (Bacteroides gingivalis)
Description:
A0AAE9XL09
Residue:
242
Sequence:
MKKIVLFSAAMAMLVACGNQTTQTKSDTPTAAVEGRISEVLTQDIQQGLTPEAVLVGLQEGNARYVANKQLPRDLNAQAVAGLEGQFPEAIILSCIDSRVPVEYIFDKGIGDLFVGRVAGNVVDDHMLGSLEYACEVSGSKVLLVLGHEDCGAIKSAIKGVEMGNITSLMEEIKPSVEATQYTGERTYANKEFADAVVKENVIQTMDEIRRDSPILKKLEEEGKIKICGAIYEMSTGKVHFL
  
Inhibitor
Name:
BDBM10880
Synonyms:
Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolamide | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Acetazolamide, AZA | AZA | Acetazolamide, 5 | Sulfonamide, 1 | Acerazolamide, AAZ | Acetazolamide, AZM | sulfonamide 1 | Acetazolamide (AAZ) | Acetazolamide (AZM) | AZM acetazolamide | Acetazolamide (AZA) | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide
Type:
Small organic molecule
Emp. Form.:
C4H6N4O3S2
Mol. Mass.:
221.99
SMILES:
CC(=O)Nc1nnc(s1)S(=O)(=O)N
Structure:
Search PDB for entries with ligand similarity: