Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Aldo-keto reductase family 1 member C3/Glutathione S-transferase P
Ligand
BDBM254817
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
pH
7.0000±n/a
IC50
8.9±n/a nM
Comments
extracted
Citation
Bothe, U; Barak, N; Busemann, M; Fischer, OM; Rotgeri, A; Gashaw, I; Hartung, I; Marquardt, T Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, processes for their preparation, pharmaceutical preparations comprising them and their use for preparing medicaments US Patent US9487554 Publication Date 11/8/2016 More Info.:
Target
Name:
Aldo-keto reductase family 1 member C3/Glutathione S-transferase P
Synonyms:
GST-Aldo-keto reductase family 1 member C3 (AKR1C3)
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Glutathione S-transferase P
Synonyms:
GST class-pi | Glutathione S-transferase P | Glutathione S-transferase (GST) | GSTP1-1 | Glutathione S-transferase | GSTP1_HUMAN | GSTP1 | FAEES3 | GST3 | Glutathione S-transferase Pi | Glutathione transferase (GST)
Type:
Enzyme
Mol. Mass.:
23353.53
Organism:
Human
Description:
P09211
Residue:
210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ
Component 2
Name:
Aldo-keto reductase family 1 member C3
Synonyms:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | Dihydrodiol dehydrogenase type I | Estradiol 17-beta-dehydrogenase | Testosterone 17-beta-dehydrogenase 5 | Aldo-keto reductase family 1 member C3 | Aldo-keto reductase family 1 member C3 (AKR1C3) | Aldo-keto reductase family 1 member C3 (AK1C3) | Dihydrodiol dehydrogenase 3 | 3-alpha-HSD type 2 | Prostaglandin F synthase | Aldo-keto reductase family 1 member C3 (AK1C3a) | AK1C3_HUMAN | AKR1C3 | DDH1 | HSD17B5 | KIAA0119 | PGFS | Aldo-keto-reductase family 1 member C3 | 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3)
Type:
Enzyme
Mol. Mass.:
36859.86
Organism:
Human
Description:
P42330
Residue:
323
Sequence:
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY
Inhibitor
Name:
BDBM254817
Synonyms:
US9487554, 4
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
