Reaction Details Report a problem with these data
Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Ligand
BDBM6850
Substrate
Autocamtide-2
Meas. Tech.
CDK Kinase Inhibition Assay
Temperature
298.1500±n/a K
IC50
174±n/a nM
Comments
extracted
Citation
 Engler, TA; Furness, K; Malhotra, S; Sanchez-Martinez, C; Shih, C; Xie, W; Zhu, G; Zhou, X; Conner, S; Faul, MM; Sullivan, KA; Kolis, SP; Brooks, HB; Patel, B; Schultz, RM; DeHahn, TB; Kirmani, K; Spencer, CD; Watkins, SA; Considine, EL; Dempsey, JA; Ogg, CA; Stamm, NB; Anderson, BD; Campbell, RM; Vasudevan, V; Lytle, ML Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles. Bioorg Med Chem Lett 13:2261-7 (2003) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:
calcium/calmodulin-dependent protein kinase II alpha subunit | Calcium/calmodulin-dependent protein kinase type II, rat brain | CaM Kinase II | KCC2A_RAT | Camk2a
Type:
Enzyme Mixture
Mol. Mass.:
54120.65
Organism:
Rat
Description:
Consists of subunits of M.W. 50,000 and 58,000-60,000 in a 3:1 ratio.
Residue:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
  
Inhibitor
Name:
BDBM6850
Synonyms:
5-[3-(diethylamino)propyl]-18-methyl-3,13,18-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4(9),5,7,11(15),17(21),19,22-nonaene-12,14-dione | indolocarbazole deriv. 14l
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Autocamtide-2
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
3697.73
Organism:
n/a
Description:
n/a
Residue:
36
Sequence:
LYSLYSALALEARGARGGLNGLTHRVALASPALALE