Target
Mitogen-activated protein kinase 1
Ligand
BDBM417975
Substrate
n/a
Meas. Tech.
ERK2 In Vitro Inhibition Assay
IC50
1.70±n/a nM
Citation
 Berdini, VBuck, IMDay, JEGriffiths-Jones, CMHeightman, TDHoward, SMurray, CWNorton, DO Reilly, MWoolford, AJCooke, MLCousin, DOnions, STShannon, JMWatts, JP Benzolactam compounds as protein kinase inhibitors US Patent  US10457669 Publication Date 10/29/2019 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Human
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM417975
Synonyms:
US10457669, Example 642 | US11001575, Example 642
Type:
Small organic molecule
Emp. Form.:
C27H27ClF2N6O5
Mol. Mass.:
588.99
SMILES:
OC[C@@H](NC(=O)CN1Cc2ncc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)c1cccc(OC(F)F)c1 |r|
Structure:
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