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Target
Receptor tyrosine-protein kinase erbB-2
Ligand
BDBM5446
Substrate
n/a
IC50
454±n/a nM
Citation
 Dong, Y; Shih, C Quinazoline derivatives substituted by aniline, preparation method and use thereof US Patent  US10507209 Publication Date 12/17/2019 
Target
Name:
Receptor tyrosine-protein kinase erbB-2
Synonyms:
MLN 19 | HER-2 Substrate | Tyrosine kinase-type cell surface receptor HER2 | 2.7.10.1 | ErbB-2/ErbB-3 heterodimer | C-erbB-2 | FASN/HER2 | Metastatic lymph node gene 19 protein | NGL | CD_antigen=CD340 | ERBB2 | MLN19 | Proto-oncogene Neu | p185erbB2 | Proto-oncogene c-ErbB-2 | HER2 | ERBB2_HUMAN | NEU
Type:
n/a
Mol. Mass.:
137894.47
Organism:
Human
Description:
P04626
Residue:
1255
Sequence:
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
  
Inhibitor
Name:
BDBM5446
Synonyms:
Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine | CHEMBL553 | ERLOTINIB HYDROCHLORIDE | cid_176870 | Erotinib | N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride | Tarceva | US9409845, Table 1, Compound 22: erlotinib | US10189853, erlotinib | US9730934, Erlotinib | US10507209, Compound Erlotinib | US11524945, Compound Erlotinib | WO2022090481, Example erlotinib
Type:
Small organic molecule
Emp. Form.:
C22H23N3O4
Mol. Mass.:
393.17
SMILES:
COCCOc1cc2c(cc1OCCOC)ncnc2Nc3cccc(c3)C#C
Structure:
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