Reaction Details Report a problem with these data
Target
Adenosine 5'-monophosphoramidase HINT1
Ligand
BDBM426057
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
Kd
810±110 nM
Citation
 Wagner, CR; Shah, R Sulfamide and sulfamate inhibitors of hHint1 US Patent  US10513520 Publication Date 12/24/2019 
Target
Name:
Adenosine 5'-monophosphoramidase HINT1
Synonyms:
Adenosine 5'-monophosphoramidase | PKCI-1 | Protein kinase C-interacting protein 1 | Protein kinase C inhibitor 1 | HINT1_HUMAN | HINT1 | HINT | PKCI1 | PRKCNH1 | Histidine triad nucleotide-binding protein 1
Type:
PROTEIN
Mol. Mass.:
13803.77
Organism:
Human
Description:
ChEMBL_795618
Residue:
126
Sequence:
MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
  
Inhibitor
Name:
BDBM426057
Synonyms:
US10513520, Compound 4
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Nc1nc2c(ncn2[C@@H]2O[C@H](COS(=O)(=O)NC(=O)CCc3c[nH]c4ccccc34)[C@H](O)[C@@H]2O)c(=O)[nH]1
Structure:
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