Reaction Details Report a problem with these data
Target
Estrogen receptor
Ligand
BDBM50494961
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Displacement
Kd
320±40 nM
Citation
 Donaldson, WA; Sem, DS; Neumann, TS Substituted (4'-hydroxyphenyl)cyclohexane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform US Patent  US10570077 Publication Date 2/25/2020 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | Estradiol receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | Nuclear receptor subfamily 3 group A member 1 | Estrogen receptor | ESR1_HUMAN | ESR1 | ESR | NR3A1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Human
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50494961
Synonyms:
CHEMBL3099428 | US10570077, Compound 11
Type:
Small organic molecule
Emp. Form.:
C22H30O2
Mol. Mass.:
326.48
SMILES:
C[C@@H](CCO)C1=CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C
Structure:
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