Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM400280
Substrate
n/a
Meas. Tech.
In vitro JAK Kinase Assay
IC50
30.0±n/a nM
Citation
 Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent  US10695337 Publication Date 6/30/2020
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
Tyrosine-protein kinase JAK2 (aa 828-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35522.23
Organism:
Homo sapiens (Human)
Description:
aa 828-1132
Residue:
304
Sequence:
ALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM400280
Synonyms:
US10695337, Example 35 | US11285140, Example 35 | US9999619, Example 36
Type:
Small organic molecule
Emp. Form.:
C26H24F2N8O
Mol. Mass.:
502.5186
SMILES:
Fc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Structure:
Search PDB for entries with ligand similarity: