Target
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM449559
Substrate
n/a
Meas. Tech.
Binding AlphaLISA Assay
IC50
0.022±n/a nM
Citation
Target
Name:
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]/Bcl-2-like protein 11 [51-76] | Mcl-1 and BIM | Mcl-1/BIM
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
  
Component 2
Name:
Bcl-2-like protein 11 [51-76]
Synonyms:
B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (51-76) | Bcl-2-like protein 11 (BIM) (51-76)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
2530.22
Organism:
Homo sapiens (Human)
Description:
O43521[51-76]
Residue:
26
Sequence:
EGDSCPHGSPQGPLAPPASPGPFATR
  
Inhibitor
Name:
BDBM449559
Synonyms:
US10703733, Example 172 | US10988451, Example 172 | US11643400, Example 172
Type:
Small organic molecule
Emp. Form.:
C38H49ClN4O6S
Mol. Mass.:
725.337
SMILES:
CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@](C)(O)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,wU:9.8,30.31,15.14,17.17,wD:2.1,47.49,44.47,6.6,9.10,17.18,t:3,(-.39,6.42,;1.1,6.03,;1.5,4.54,;.41,3.45,;-1.08,3.85,;-2.17,2.76,;-1.77,1.27,;-.28,1.67,;-2.86,.18,;-2.46,-1.3,;-2.06,-2.79,;-3.79,-2.07,;-5.13,-1.3,;-5.13,.24,;-6.46,-2.07,;-7.8,-1.3,;-9.28,-1.7,;-9.68,-.22,;-11.17,-.61,;-10.45,1.12,;-8.19,.18,;-.97,-1.7,;.12,-.61,;-.28,.87,;1.6,-1.01,;2,-2.5,;3.49,-2.9,;4.4,-1.88,;5.64,-2.89,;7.12,-2.6,;7.84,-1.24,;8.55,.13,;10.09,.2,;10.92,-1.1,;10.21,-2.46,;11.04,-3.76,;10.34,-5.13,;11.17,-6.42,;8.8,-5.2,;7.97,-3.9,;8.68,-2.54,;7.12,.17,;5.64,.57,;5.14,2.2,;3.53,2.62,;2.18,1.83,;1.78,3.32,;3.13,4.1,;4.22,-.4,;2.69,.08,)|
Structure:
Search PDB for entries with ligand similarity: