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Target
Activin receptor type-1
Ligand
BDBM488090
Substrate
n/a
Meas. Tech.
Enzyme Inhibitory Assay
IC50
34.0±n/a nM
Citation
 Hashizume, Y; Sekimata, K; Kubota, H; Yamamoto, H; Koda, Y; Koyama, H; Taguri, T; Sato, T; Tanaka, A; Miyazono, K BMP-signal-inhibiting compound US Patent  US10954216 Publication Date 3/23/2021 
Target
Name:
Activin receptor type-1
Synonyms:
ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I | Q04771 | 2.7.11.30 | Activin receptor-like kinase 2 (ALK2/ACVR1) | Activin receptor-like kinase 2 (ALK-2) | SKR1 | ALK-2 | ACVR1_HUMAN | ACVRLK2 | ALK2/ACVR1 | ACTR-I
Type:
n/a
Mol. Mass.:
57158.32
Organism:
Human
Description:
n/a
Residue:
509
Sequence:
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM488090
Synonyms:
4-(1-Ethyl-3-(pyridin- 3-yl)-1H-pyrazol-4- yl)-N-(4-(piperazin-1- yl)phenyl)pyrimidin-2- amine | US10954216, Example 151
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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