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Target
Angiotensin-converting enzyme 2
Ligand
BDBM496843
Substrate
n/a
Meas. Tech.
Antiviral Activity Assay
EC50
1200±n/a nM
Citation
 Shen, Z; Ratia, K; Cooper, L; Kong, D; Lee, H; Kwon, Y; Li, Y; Alqarni, S; Huang, F; Dubrovskyi, O; Rong, L; Thatcher, GRJ; Xiong, R Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity. J Med Chem 0:0 (2021) [PubMed]  Article 
Target
Name:
Angiotensin-converting enzyme 2
Synonyms:
Angiotensin-converting enzyme-related carboxypeptidase | ACEH | ACE-related carboxypeptidase | Angiotensin-converting enzyme homolog | Metalloprotease MPROT15 | ACE2_HUMAN | ACE2
Type:
Enzyme
Mol. Mass.:
92448.86
Organism:
Human
Description:
n/a
Residue:
805
Sequence:
MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTDDVQTSF
  
Inhibitor
Name:
BDBM496843
Synonyms:
SARS-CoV-2 PLpro Inhibitor, 73 | US20240166598, Compound XR8-24
Type:
Small Organic Molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: