Target
Nuclear receptor ROR-gamma
Ligand
BDBM504171
Substrate
n/a
Meas. Tech.
Transcreener-Fluorecescence Polarization Assay
Ki
3.80±n/a nM
Citation
 Bryan, MCDo, SDrobnick, JGobbi, AKatsumoto, TKiefer, Jr., JRLiang, JRajapaksa, NSChen, YFu, LLai, KWLiu, ZWai, JWang, F Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators US Patent  US11034698 Publication Date 6/15/2021 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM504171
Synonyms:
N-[2,2-dimethyl-6-[4-[(4- methyl-1H-imidazol-5- yl)methyl]piperazin-1-yl]-3H- benzofuran-5-yl]pyrazolo[l,5- a]pyrimidine-3-carboxamide | US11034698, Example 8
Type:
Small organic molecule
Emp. Form.:
C26H30N8O2
Mol. Mass.:
486.5688
SMILES:
Cc1nc[nH]c1CN1CCN(CC1)c1cc2OC(C)(C)Cc2cc1NC(=O)c1cnn2cccnc12
Structure:
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