Target
Nuclear receptor ROR-gamma
Ligand
BDBM504246
Substrate
n/a
Meas. Tech.
Transcreener-Fluorecescence Polarization Assay
Ki
1.90±n/a nM
Citation
 Bryan, MCDo, SDrobnick, JGobbi, AKatsumoto, TKiefer, Jr., JRLiang, JRajapaksa, NSChen, YFu, LLai, KWLiu, ZWai, JWang, F Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators US Patent  US11034698 Publication Date 6/15/2021 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM504246
Synonyms:
N-[6-(Dimethylamino)-2- isopropyl-1-oxo-isoindolin-5- yl]pyrazolo[1,5-a]pyrimidine-3- carboxamide | US11034698, Example 95
Type:
Small organic molecule
Emp. Form.:
C20H22N6O2
Mol. Mass.:
378.4277
SMILES:
CC(C)N1Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2C1=O)N(C)C
Structure:
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