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Report error Found 1720 of affinity data for UniProtKB/TrEMBL: P13569
TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50625825(CHEMBL5423437)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity at human wildtype CFTR assessed as inhibition constant by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataKi:  4.80E+3nMAssay Description:Binding affinity at human wildtype CFTR assessed as inhibition constant by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataKi:  8.10E+4nMAssay Description:Inhibition of forskolin-stimulated CFTR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50434312(CHEMBL2386374)
Affinity DataIC50:  4nMAssay Description:Inhibition of wild type human CFTR chloride conductance expressed in forskolin-stimulated rat FRT cells by short-circuit current analysis in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50343996(2,4-dimethylpyrido[1,2-a]pyrimidin-5-ium-3-olate |...)
Affinity DataIC50:  5nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353351(CHEMBL1831075)
Affinity DataIC50:  8nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50343998((2S,3R,4R)-3,4-dihydroxy-2,4-dimethyl-3,4-dihydro-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50343998((2S,3R,4R)-3,4-dihydroxy-2,4-dimethyl-3,4-dihydro-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50343997(2,4-dimethylpyrimido[2,1-a]isoquinolin-5-ium-3-ola...)
Affinity DataIC50:  16nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353345(CHEMBL1831069)
Affinity DataIC50:  25nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353349(CHEMBL1831073)
Affinity DataIC50:  25nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353346(CHEMBL1831070)
Affinity DataIC50:  25nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353351(CHEMBL1831075)
Affinity DataIC50:  40nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM300426(US10130622, Example 00005)
Affinity DataIC50:  40nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353338(CHEMBL1831058)
Affinity DataIC50:  50nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353349(CHEMBL1831073)
Affinity DataIC50:  50nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353350(CHEMBL1831074)
Affinity DataIC50:  80nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353338(CHEMBL1831058)
Affinity DataIC50:  90nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50324734(7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human CFTR expressed in rat FRT cells assessed as inhibition of CPT-cAMP-induced apical membrane current in presence of transepithelial...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353341(CHEMBL1831064)
Affinity DataIC50:  90nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353339(CHEMBL1831059)
Affinity DataIC50:  100nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50324734(7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353346(CHEMBL1831070)
Affinity DataIC50:  100nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM300426(US10130622, Example 00005)
Affinity DataIC50:  102nMAssay Description:YFP-Halide Influx Assay for the CFTR-ΔF508 Mutation and Suppressor mutants (I539T or G550E)The YFP halide influx assay measures the functionalit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM300426(US10130622, Example 00005)
Affinity DataIC50:  103nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM300427(US10130622, Example 00006)
Affinity DataIC50:  104nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353345(CHEMBL1831069)
Affinity DataIC50:  120nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM300428(BDBM300430 | US10130622, Example 00007)
Affinity DataIC50:  138nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)
Affinity DataIC50:  140nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353337(CHEMBL1831057)
Affinity DataIC50:  150nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353342(CHEMBL1831066)
Affinity DataIC50:  150nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353339(CHEMBL1831059)
Affinity DataIC50:  170nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353347(CHEMBL1831071)
Affinity DataIC50:  170nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353348(CHEMBL1831072)
Affinity DataIC50:  170nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353341(CHEMBL1831064)
Affinity DataIC50:  200nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50324734(7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353334(CHEMBL1831054)
Affinity DataIC50:  300nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50244767(4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)th...)
Affinity DataIC50:  300nMAssay Description:Inhibition of CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50244767(4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)th...)
Affinity DataIC50:  300nMAssay Description:Inhibition of CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353340(CHEMBL1831060)
Affinity DataIC50:  350nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353343(CHEMBL1831067)
Affinity DataIC50:  370nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50244767(4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)th...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human wild type CFTR expressed in rat FRT cells assessed as chloride current by short-circuit current measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM300427(US10130622, Example 00006)
Affinity DataIC50:  417nMAssay Description:YFP-Halide Influx Assay for the CFTR-ΔF508 Mutation and Suppressor mutants (I539T or G550E)The YFP halide influx assay measures the functionalit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM300428(BDBM300430 | US10130622, Example 00007)
Affinity DataIC50:  496nMAssay Description:YFP-Halide Influx Assay for the CFTR-ΔF508 Mutation and Suppressor mutants (I539T or G550E)The YFP halide influx assay measures the functionalit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353353(CHEMBL1831065)
Affinity DataIC50:  500nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353344(CHEMBL1831068)
Affinity DataIC50:  600nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50416575(CHEMBL1222175)
Affinity DataIC50:  700nMAssay Description:Inhibition of human CFTR expressed in rat FRT cells coexpressing halide indicator YFP-H148Q assessed as inhibition of halide influx preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50244768(5-[[4-(2H-Tetrazol-5-yl)phenyl]methylene]-2-thioxo...)
Affinity DataIC50:  760nMAssay Description:Inhibition of human wild type CFTR expressed in rat FRT cells assessed as chloride current by short-circuit current measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50416577(CHEMBL1081471)
Affinity DataIC50:  800nMAssay Description:Inhibition of human CFTR expressed in rat FRT cells coexpressing halide indicator YFP-H148Q assessed as inhibition of halide influx preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystic fibrosis transmembrane conductance regulator(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50416576(CHEMBL1222176)
Affinity DataIC50:  800nMAssay Description:Inhibition of human CFTR expressed in rat FRT cells coexpressing halide indicator YFP-H148Q assessed as inhibition of halide influx preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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