BDBM238158 US10017502, Example 4::US9394291, 4

SMILES CNC(=O)CC1COc2cc(F)ccc2N1C(=O)c1ccc2OCC(=O)Nc2c1

InChI Key InChIKey=MBKYLPOPYYLTNW-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 238158   

TargetMineralocorticoid receptor [729-984](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM238158(US10017502, Example 4 | US9394291, 4)
Affinity DataIC50:  180nMpH: 7.5Assay Description:Test A1: Briefly, in Test A1 the assay was run in 384 well format in 10 mM Tris-HCl, pH 7.5, 0.5 mM EDTA 20 mM NaMoO4, 0.1 mM DTT and 10% glycerol at...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor [729-984](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM238158(US10017502, Example 4 | US9394291, 4)
Affinity DataIC50:  740nMAssay Description:Test A1 and A2: In order to identify binding to the human MR LBD a scintillation proximity assay (SPA) was adapted to the 384-well format. The MR-LBD...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor [729-984](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM238158(US10017502, Example 4 | US9394291, 4)
Affinity DataIC50:  180nMAssay Description:Test A1 and A2: In order to identify binding to the human MR LBD a scintillation proximity assay (SPA) was adapted to the 384-well format. The MR-LBD...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor [729-984](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM238158(US10017502, Example 4 | US9394291, 4)
Affinity DataIC50:  740nMpH: 7.5Assay Description:Test A2: Briefly, in Test A1 the assay was run in 384 well format in 10 mM Tris-HCl, pH 7.5, 0.5 mM EDTA 20 mM NaMoO4, 0.1 mM DTT and 10% glycerol at...More data for this Ligand-Target Pair