BDBM26623 (5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolidine-2,4-dione::US8637558, 41::thiazolidine-2,4-dione, 1a

SMILES Cc1ccc(C=C2SC(O)=NC2=O)cc1

InChI Key InChIKey=VUXDSWRSGDQYRJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26623   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Medical University Of South Carolina

LigandPNGBDBM26623((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...)
Affinity DataIC50:  60nMpH: 7.0 T: 2°CAssay Description:The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Industry-Academic Cooperation Foundation, Chosun University

US Patent
LigandPNGBDBM26623((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...)
Affinity DataIC50:  5.82E+3nMpH: 7.5Assay Description:Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Medical University Of South Carolina

LigandPNGBDBM26623((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...)
Affinity DataIC50:  4.40E+3nMAssay Description:The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed