BDBM407374 4-(((1r,4R)-4-aminocyclo- hexyl)amino)-6-(3-cyano- pyrrolo[1,2-b]pyridazin-7- yl)-N-((R)-2-fluoro-3- hydroxy-3-methylbutyl) nicotinamide::US10336762, Compound 316

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1N[C@H]1CC[C@H](N)CC1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=BKCHWCDBZORKDL-SEPYTNNBSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407374   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407374(4-(((1r,4R)-4-aminocyclo- hexyl)amino)-6-(3-cyano-...)
Affinity DataIC50: <1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407374(4-(((1r,4R)-4-aminocyclo- hexyl)amino)-6-(3-cyano-...)
Affinity DataEC50:  136nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent