TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.0320nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.0360nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.190nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.210nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.210nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.280nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.520nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 0.850nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.04nMAssay Description:Displacement of [3H]AVP from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 1.48nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.95nMAssay Description:Displacement of [3H]AVP from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1b receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1b receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Institute Genomics Functional (Igf)
Curated by ChEMBL
Institute Genomics Functional (Igf)
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at TLR4 in human PBMC assessed as inhibition of LPS-stimulated TNFalpha production preincubated for 30 mins before LPS challenge ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at TLR4 in human PBMC assessed as inhibition of LPS-stimulated TNFalpha production preincubated for 30 mins before LPS challenge ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.60E+5nMAssay Description:Activation of human TLR8 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.31E+5nMAssay Description:Activation of human TLR8 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.70E+4nMAssay Description:Activation of human TLR8 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.90E+4nMAssay Description:Activation of human TLR8 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.95E+3nMAssay Description:Activation of human TLR7 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Activation of human TLR7 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 620nMAssay Description:Activation of human TLR7 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Activation of human TLR7 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Activation of human TLR7 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 230nMAssay Description:Activation of human TLR7 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.80E+3nMAssay Description:Activation of human TLR8 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.31E+5nMAssay Description:Activation of human TLR8 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.780nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 4.99nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 15.7nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 0.251nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 5.89nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 13.7nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 64nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 3.95nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 1.32nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 152nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 19.7nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 41nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 1.39nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 2.90nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 2.13E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+4nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.14E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.25E+4nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair