TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery
Curated by ChEMBL
Nimbus Discovery
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of N-terminal GST-fused full-length human IRAK4 (1 to 460 amino acids) assessed as reduction in phosphorylated substrates by Caliper assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery
Curated by ChEMBL
Nimbus Discovery
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery
Curated by ChEMBL
Nimbus Discovery
Curated by ChEMBL
Affinity DataKi: 7.5nMAssay Description:Inhibition of N-terminal GST-fused full-length human IRAK4 (1 to 460 amino acids) assessed as reduction in phosphorylated substrates by Caliper assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery
Curated by ChEMBL
Nimbus Discovery
Curated by ChEMBL
Affinity DataKi: 50nMAssay Description:Inhibition of N-terminal GST-fused full-length human IRAK4 (1 to 460 amino acids) assessed as reduction in phosphorylated substrates by Caliper assayMore data for this Ligand-Target Pair
Affinity DataKi: 79nM ΔG°: -40.1kJ/mole IC50: 70nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataKi: 3.21E+3nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 3.36E+3nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 4.10E+3nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 4.90E+3nM ΔG°: -30.0kJ/mole IC50: 4.60E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataKi: 5.00E+3nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 5.96E+3nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 6.69E+3nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 8.78E+3nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 9.93E+3nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 1.09E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 1.33E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 1.87E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 3.45E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 3.71E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 4.20E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 4.25E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 5.38E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 7.38E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 9.39E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 1.89E+5nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
Affinity DataKi: 4.40E+5nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery
Curated by ChEMBL
Nimbus Discovery
Curated by ChEMBL
Affinity DataIC50: 0.240nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human PKCtheta by IMAP fluorescence polarization technologyMore data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery
Curated by ChEMBL
Nimbus Discovery
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Inhibition of IRAK4 (unknown origin) by fluorescence polarization based kinase assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery
Curated by ChEMBL
Nimbus Discovery
Curated by ChEMBL
Affinity DataIC50: 0.360nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.440nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human PKCtheta by IMAP fluorescence polarization technologyMore data for this Ligand-Target Pair
Affinity DataIC50: 0.490nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.670nMAssay Description:Inhibition of human PKCtheta by IMAP fluorescence polarization technologyMore data for this Ligand-Target Pair
Affinity DataIC50: 0.840nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery
Curated by ChEMBL
Nimbus Discovery
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human PKCtheta by IMAP kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human PKCtheta by IMAP fluorescence polarization technologyMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PKCtheta by IMAP fluorescence polarization technologyMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery
Curated by ChEMBL
Nimbus Discovery
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of IRAK4 (unknown origin) using fluoresceinated peptide and ATP after 60 mins by by Caliper assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human PKCtheta by IMAP fluorescence polarization technologyMore data for this Ligand-Target Pair