BDBM50239328 2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile::CHEMBL402818
SMILES CN(C)Cc1cccc(c1)-c1cc2c(Nc3ccc4[nH]ccc4c3C)c(cnc2s1)C#N
InChI Key InChIKey=CSCOHEYTBLBQMG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50239328
Affinity DataIC50: 26nMAssay Description:Inhibition of human full length PKCdeltaMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human full length PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of mouse PKCtheta in KO cells assessed as blockade of anti CD28-stimulated IL2 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of PKCtheta in wild type T-cell assessed as blockade of anti CD3-stimulated IL2 productionMore data for this Ligand-Target Pair