Affinity DataIC50: 0.184nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 0.351nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.542nMAssay Description:Inhibition of human PKCa using histone H1 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.08nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.39nMAssay Description:Inhibition of human LYN using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 1.58nMAssay Description:Inhibition of human PKACA using LCGRTGRRNSI as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 1.76nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.35nMAssay Description:Inhibition of human YES/YES1 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.68nMAssay Description:Inhibition of human LCK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.76nMAssay Description:Inhibition of human PKCg using histone H1 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 3.82nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 5.94nMAssay Description:Inhibition of human AKT1 using KGSGSGRPRTSSFAEG as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 12.4nMAssay Description:Inhibition of human ZAP70 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 18.1nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human FAK/PTK2 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 20.3nMAssay Description:Inhibition of human CDK4/cyclinD1 using RB-CTF as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 45.8nMAssay Description:Inhibition of human MEK1 using ERK2 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 76nMAssay Description:Inhibition of human ABL1 using EAIYAAPFAKKK as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 111nMAssay Description:Inhibition of human mTOR/FRAP1 using 4EBP1 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 356nMAssay Description:Inhibition of recombinant human GST-tagged Mps1/TTK (507 to 1400 residues) using recombinant cetn2 as substrate in presence of [gamma-32P]ATP measure...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 580nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 581nMAssay Description:Inhibition of human JNK1 using ATF2 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 809nMAssay Description:Inhibition of recombinant human GST-tagged Mps1/TTK (507 to 1400 residues) using recombinant cetn2 as substrate in presence of [gamma-32P]ATP measure...More data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 850nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 870nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 891nMAssay Description:Inhibition of human FAK/PTK2 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 910nMAssay Description:Inhibition of aromatase in human SKBR3 cells by tritiated water release assayMore data for this Ligand-Target Pair