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Found 626 with Last Name = 'ives' and Initial = 'j'
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014156(4-(2-Methoxy-phenyl)-2-(5-methyl-1H-imidazol-4-ylm...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014164(8-[2-(5-Methyl-1H-imidazol-4-ylmethyl)-thiazol-4-y...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Mus musculus (house mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50000492((zacopride)4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.30nMAssay Description:The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014159(4-(2-Fluoro-phenyl)-2-(5-methyl-1H-imidazol-4-ylme...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Yale University

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataKi:  3nMAssay Description:Effective concentration required against L100I mutant HIV-1 reverse transcriptase (as per ref 8 in the article)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  3.80nMAssay Description:The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  8.70nMAssay Description:The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013043(3-[2-(5-Methyl-1H-imidazol-4-ylmethyl)-thiazol-4-y...)
Affinity DataKi:  12nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi:  12nMAssay Description:The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Yale University

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataKi:  17nMAssay Description:Binding affinity towards L100I mutant HIV-1 reverse transcriptase (as per ref 10 in the article)More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Yale University

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataKi:  17nMAssay Description:Effective concentration required against wild type HIV-1 reverse transcriptase (as per ref 6 in the article)More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Plasmodium falciparum)
Yale University

Curated by ChEMBL
LigandPNGBDBM50399046(CHEMBL2178862)
Affinity DataKi:  38nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Plasmodium falciparum)
Yale University

Curated by ChEMBL
LigandPNGBDBM50399047(CHEMBL2178856)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Plasmodium falciparum)
Yale University

Curated by ChEMBL
LigandPNGBDBM50399054(CHEMBL2178851)
Affinity DataKi:  43nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206084(CHEMBL3899123)
Affinity DataKi:  48nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206030(CHEMBL3957289 | US10336721, Example 22 | US1096819...)
Affinity DataKi:  74nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50280114(CHEMBL4160035)
Affinity DataKi:  75nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50280113(CHEMBL4170679)
Affinity DataKi:  90nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206094(CHEMBL3960793)
Affinity DataKi:  144nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50167985(CHEMBL3798384 | US10336721, Example 21 | US1096819...)
Affinity DataKi:  160nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206085(CHEMBL3924400)
Affinity DataKi:  200nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206061(CHEMBL3953102 | US10336721, Example 1 | US10968198...)
Affinity DataKi:  230nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222218(CHEBI:51137 | Mianserin)
Affinity DataKi:  252nMAssay Description:The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206087(CHEMBL3897449)
Affinity DataKi:  260nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206090(CHEMBL3915405)
Affinity DataKi:  360nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  361nMAssay Description:The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50280115(CHEMBL4169208)
Affinity DataKi:  363nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Plasmodium falciparum)
Yale University

Curated by ChEMBL
LigandPNGBDBM50399062(CHEMBL2178843)
Affinity DataKi:  370nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Plasmodium falciparum)
Yale University

Curated by ChEMBL
LigandPNGBDBM50399048(CHEMBL2178861)
Affinity DataKi:  370nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206093(CHEMBL3925522)
Affinity DataKi:  530nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for 5-hydroxytryptamine 1B receptor was determined by using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for 5-hydroxytryptamine 1C receptor was determined by using [3H]- mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Mus musculus (Mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for Dopamine receptor D1 was determined by using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for Dopamine receptor D2 was determined by using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for Opioid receptor mu 1 was determined by using [3H]naloxone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(BOVINE)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for 5-hydroxytryptamine 2 receptor was determined by using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for Muscarinic acetylcholine receptor was determined by using [3H]QNB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor was determined by using [3H]p-aminoclonidine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for Beta adrenergic receptor was determined by using [3H]dihydroalprenolol as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for Sigma opioid receptor was determined by using [3H](+)-3-(3-hydroxyphenyl)N-1-propyl-piperdine((+)-3-PPP) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for Alpha-1 adrenergic receptor was determined by using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Mus musculus (Mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor was determined by using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for 5-hydroxytryptamine 1D receptor was determined by using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Plasmodium falciparum)
Yale University

Curated by ChEMBL
LigandPNGBDBM50399056(CHEMBL2178849)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014406(2-Me 5-HT | 2-Methyl-5-hydroxytryptamine | 2-methy...)
Affinity DataKi:  1.43E+3nMAssay Description:The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Plasmodium falciparum)
Yale University

Curated by ChEMBL
LigandPNGBDBM50399051(CHEMBL2178855)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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