BDBM50206083 CHEMBL3927658::US10968198, Example 43

SMILES OC(=O)CCCOc1ccc2nc(ccc2c1)-c1cn(nn1)-c1ccc(O)c(F)c1

InChI Key InChIKey=LRNISQSDGNCOPP-UHFFFAOYSA-N

Data  3 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50206083   

TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

US Patent
LigandPNGBDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  34nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

US Patent
LigandPNGBDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

US Patent
LigandPNGBDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

US Patent
LigandPNGBDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKd:  63nMAssay Description:Inhibition of recombinant human MIF tautomerase activity assessed as decrease in formation of borate complex of enol product using 4-HPP as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed