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Found 182 with Last Name = 'leclerc' and Initial = 'g'
TargetType-1 angiotensin II receptor A(RAT)
Laboratoires Fournier

Curated by ChEMBL
LigandPNGBDBM50082568(2-({3-[4-(2-Azido-benzenesulfonylaminocarbonyl)-be...)
Affinity DataKi:  1.5nMAssay Description:The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A(RAT)
Laboratoires Fournier

Curated by ChEMBL
LigandPNGBDBM50082567(2-({2-Butyl-3-[4-(2-chloro-benzenesulfonylaminocar...)
Affinity DataKi:  2.5nMAssay Description:The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A(RAT)
Laboratoires Fournier

Curated by ChEMBL
LigandPNGBDBM50082570(2-[2-butyl-1-(4-carboxybenzyl)-1H-5-imidazolylmeth...)
Affinity DataKi:  12.1nMAssay Description:The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A(RAT)
Laboratoires Fournier

Curated by ChEMBL
LigandPNGBDBM50082569(4-Azido-2-{[2-butyl-3-(4-carboxy-benzyl)-3H-imidaz...)
Affinity DataKi:  22nMAssay Description:The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataIC50:  0.600nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)
Affinity DataIC50:  7nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068078(CHEMBL142239 | {5-[1-(1-Methoxy-naphthalen-2-yl)-m...)
Affinity DataIC50:  9nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataIC50:  9.10nMAssay Description:Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataIC50:  10nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataIC50:  10nMAssay Description:Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068085(CHEMBL358284 | {5-[1-(1-Bromo-naphthalen-2-yl)-met...)
Affinity DataIC50:  11nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068083(CHEMBL358825 | {5-[1-(3-Bromo-naphthalen-2-yl)-met...)
Affinity DataIC50:  15nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068086(CHEMBL142701 | {5-[1-(3-Methoxy-naphthalen-2-yl)-m...)
Affinity DataIC50:  20nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228240(CHEMBL284056)
Affinity DataIC50:  41nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068074(CHEMBL142001 | {5-[1-(3-Chloro-naphthalen-2-yl)-me...)
Affinity DataIC50:  48nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068075(CHEMBL336874 | {5-[1-(1-Bromo-naphthalen-2-yl)-met...)
Affinity DataIC50:  51nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068073(CHEMBL143658 | {5-[1-(6-Methoxy-naphthalen-2-yl)-m...)
Affinity DataIC50:  67nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068076(CHEMBL143933 | {5-[1-(1-Nitro-naphthalen-2-yl)-met...)
Affinity DataIC50:  79nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068080(CHEMBL142615 | {5-[1-Naphthalen-2-yl-meth-(Z)-ylid...)
Affinity DataIC50:  96nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068084(CHEMBL142869 | {5-[1-(6-Methoxy-naphthalen-2-yl)-m...)
Affinity DataIC50:  101nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068081(CHEMBL142390 | {5-[1-(3-Methoxy-naphthalen-2-yl)-m...)
Affinity DataIC50:  128nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataIC50:  140nMAssay Description:Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068077(CHEMBL139720 | {5-[1-(1-Methoxy-naphthalen-2-yl)-m...)
Affinity DataIC50:  150nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068082(CHEMBL345945 | {5-[1-(3-Bromo-naphthalen-2-yl)-met...)
Affinity DataIC50:  153nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228236(CHEMBL3350238)
Affinity DataIC50:  210nMAssay Description:Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068079(CHEMBL142385 | {5-[1-Naphthalen-2-yl-meth-(Z)-ylid...)
Affinity DataIC50:  269nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228238(CHEMBL30911)
Affinity DataIC50:  270nMAssay Description:Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228238(CHEMBL30911)
Affinity DataIC50:  300nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228242(CHEMBL542812)
Affinity DataIC50:  380nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228244(CHEMBL553942)
Affinity DataIC50:  470nMAssay Description:Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228242(CHEMBL542812)
Affinity DataIC50:  480nMAssay Description:Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228237(CHEMBL554455)
Affinity DataIC50:  480nMAssay Description:Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228237(CHEMBL554455)
Affinity DataIC50:  500nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228241(CHEMBL540511)
Affinity DataIC50:  830nMAssay Description:Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228237(CHEMBL554455)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228244(CHEMBL553942)
Affinity DataIC50:  1.00E+3nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataIC50:  1.00E+3nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228241(CHEMBL540511)
Affinity DataIC50: >1.00E+3nMAssay Description:Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228238(CHEMBL30911)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101815(CHEBI:7550 | Nicardipine)
Affinity DataIC50:  1.40E+3nMAssay Description:Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
University Of Grenoble

Curated by ChEMBL
LigandPNGBDBM50064234(CHEMBL41628 | Dicyclopropyl-methanone O-(3-{2-[4-(...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of beta-2 adrenergic receptor isolated from rat lung homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228240(CHEMBL284056)
Affinity DataIC50:  1.60E+3nMAssay Description:Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228236(CHEMBL3350238)
Affinity DataIC50:  1.90E+3nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228236(CHEMBL3350238)
Affinity DataIC50:  1.90E+3nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228236(CHEMBL3350238)
Affinity DataIC50:  1.90E+3nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228239(CHEMBL2093965)
Affinity DataIC50:  2.00E+3nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
University Of Grenoble

Curated by ChEMBL
LigandPNGBDBM50064233(CHEMBL41149 | Dicyclopropyl-methanone O-{3-[2-(4-a...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of beta-2 adrenergic receptor isolated from rat lung homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228243(CHEMBL542814)
Affinity DataIC50:  2.00E+3nMAssay Description:Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50228241(CHEMBL540511)
Affinity DataIC50:  3.50E+3nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)

Curated by ChEMBL
LigandPNGBDBM50101815(CHEBI:7550 | Nicardipine)
Affinity DataIC50:  3.60E+3nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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