BindingDB PrimarySearch

Found 554 with Last Name = 'ma' and Initial = 'wh'

Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

Ki: 0.380nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562185(CHEMBL4746910)

Ki: 1.30nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562179(CHEMBL4739972)

Ki: 3nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)

Ki: 3.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562176(CHEMBL4778377)

Ki: 5.10nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562184(CHEMBL4744206)

Ki: 13nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562183(CHEMBL4760742)

Ki: 20nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562181(CHEMBL4747537)

Ki: 22nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562180(CHEMBL4796195)

Ki: 34nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)

Ki: 35nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562186(CHEMBL4761905)

Ki: 40nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562177(CHEMBL4763056)

Ki: 42nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562179(CHEMBL4739972)

Ki: 160nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL

BDBM249466(US10072016, Compound 65 | US10407433, Compound 65 ...)

Ki: 720nMAssay Description:Time dependent inhibition of CYP2D6 in human liver microsomes assessed as equilibrium inhibition binding constant in presence of NADPH by LC-MS/MS an...More data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562173(CHEMBL4778965)

Ki: 956nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562178(CHEMBL4740343)

Ki: >1.00E+3nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562187(CHEMBL4765186)

Ki: >1.00E+3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562186(CHEMBL4761905)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562184(CHEMBL4744206)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562183(CHEMBL4760742)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562182(CHEMBL4744466)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562181(CHEMBL4747537)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562180(CHEMBL4796195)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562178(CHEMBL4740343)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562177(CHEMBL4763056)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562176(CHEMBL4778377)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562175(CHEMBL4749663)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562174(CHEMBL4759158)

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562187(CHEMBL4765186)

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562185(CHEMBL4746910)

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Cytochrome P450 2D6(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL

BDBM50501900(CHEMBL4463039)

Ki: 3.13E+3nMAssay Description:Time dependent inhibition of CYP2D6 in human liver microsomes assessed as equilibrium inhibition binding constant in presence of NADPH by LC-MS/MS an...More data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562175(CHEMBL4749663)

Ki: 3.18E+3nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Guangdong Medical University

Curated by ChEMBL

BDBM50562173(CHEMBL4778965)

Ki: 3.19E+3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Guangdong Medical University

Curated by ChEMBL

BDBM50562174(CHEMBL4759158)

Ki: 1.15E+4nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026260(CHEMBL3359024)

IC50: 0.121nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50019040(CHEMBL1230001)

IC50: 0.155nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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3D Structure (crystal)

Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026258(CHEMBL3359022)

IC50: 0.179nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026259(CHEMBL3359023)

IC50: 0.235nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026255(CHEMBL3359017)

IC50: 0.285nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026253(CHEMBL3359014)

IC50: 0.294nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Renin(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50285792(4-Oxo-piperidine-1-carboxylic acid {(S)-1-[(R)-1-(...)

IC50: 0.300nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026256(CHEMBL3359019)

IC50: 0.340nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026254(CHEMBL3359015)

IC50: 0.481nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026251(CHEMBL3359005)

IC50: 0.554nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026244(CHEMBL3359028)

IC50: 0.829nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Aldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

BDBM16315(6-[(5-chloro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)

IC50: 0.840nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

BDBM16315(6-[(5-chloro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)

IC50: 1nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50026257(CHEMBL3359020)

IC50: 1.60nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair

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Mitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

BDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)

IC50: 2nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair

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Retinol-binding protein 4(Homo sapiens (Human))
Albany Molecular Research

Curated by ChEMBL

BDBM50501925(CHEMBL4472596)

IC50: 2.70nMAssay Description:Competitive displacement of 3[H]retinol from biotinylated RBP4 (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair

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Displayed 1 to 50 (of 554 total ) | Next | Last >>

Filter my 554 hits

Targets 42▿
- Retinol-binding protein 4 171
- Aldo-keto reductase family 1 member B1 77
- Mitogen-activated protein kinase 14 50
- C-C chemokine receptor type 1 48
- Transthyretin 33
- Glycogen phosphorylase, liver form 26
- Cytochrome P450 2D6 19
- Sigma non-opioid intracellular receptor 1 16
- Sigma intracellular receptor 2 16
- Cytochrome P450 2C9 13
- Cytochrome P450 2C19 13
- Cytochrome P450 3A4 13
- Renin 11
- Bifunctional epoxide hydrolase 2 8
- Tyrosine-protein kinase JAK2 4
- Tyrosine-protein kinase JAK1 4
- Ephrin type-A receptor 4 3
- Potassium voltage-gated channel subfamily H member 2 3
- Cyclin-dependent kinase 2 2
- MAP kinase-activated protein kinase 2 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Tyrosine-protein kinase Lck 1
- Mitogen-activated protein kinase 13 1
- Mitogen-activated protein kinase 12 1
- Mitogen-activated protein kinase 11 1
- Tyrosine-protein kinase CSK 1
- Protein kinase C alpha type 1
- Cyclin-dependent kinase 5 1
- Epidermal growth factor receptor 1
- Mitogen-activated protein kinase 8 1
- Ribosomal protein S6 kinase alpha-5 1
- RAC-alpha serine/threonine-protein kinase 1
- Ribosomal protein S6 kinase alpha-3 1
- Serine/threonine-protein kinase Chk1 1
- Kappa-type opioid receptor 1
- Ribosomal protein S6 kinase beta-1 1
- Rho-associated protein kinase 2 1
- Serine/threonine-protein kinase Sgk1 1
- MAP kinase-activated protein kinase 5 1
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 1
- Insulin receptor 1
- Glycogen synthase kinase-3 beta 1
- ...
Publications 15▿
- J Med Chem 57: 7731-57 (2014) 96
- J Med Chem 58: 5863-88 (2015) 73
- J Med Chem 62: 5470-5500 (2019) 64
- J Med Chem 48: 6326-39 (2005) 60
- Bioorg Med Chem Lett 14: 919-23 (2004) 49
- Science 302: 875-878 (2003) 34
- Bioorg Med Chem Lett 14: 2169-73 (2004) 33
- WIPO WO2022112919 (2022) 33
- Eur J Med Chem 209: (2021) 32
- J Med Chem 41: 2934-8 (1998) 26
- Bioorg Med Chem Lett 14: 2163-7 (2004) 17
- J Med Chem 46: 2283-6 (2003) 17
- Bioorg Med Chem Lett 5: 2623-2626 (1995) 9
- Bioorg Med Chem Lett 23: 2380-3 (2013) 8
- Eur J Med Chem 47: 493-500 (2012) 3
Institutions 8▿
- Pfizer 269
- Albany Molecular Research 96
- Columbia University Medical Center 73
- Albany College Of Pharmacy And Health Sciences 64
- Guangdong Medical University 32
- TBA 9
- Shanxi Medical University 8
- Vu University Amsterdam 3
Affinity: 0.12 to 1.0E+5 nM▿
- Ki 34
- IC50 486
- Kd 14
- EC50 20
- Affinity ≤ nM
Xtal structures: 8
Docked structures: 2
Catalog Cmpds: 26