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Found 26 with Last Name = 'német' and Initial = 'k'
TargetSerine protease 1(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070501(CHEMBL417682 | {(R)-1-Benzyl-2-[(R)-2-((S)-1-formy...)
Affinity DataIC50:  3nMAssay Description:Ability to inhibit Trypsin was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50305083(3-((3S,6S)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,...)
Affinity DataIC50:  5nMAssay Description:TP_TRANSPORTER: efflux of Hoechst33342 in BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070501(CHEMBL417682 | {(R)-1-Benzyl-2-[(R)-2-((S)-1-formy...)
Affinity DataIC50:  9nMAssay Description:Ability to inhibit Thrombin was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070499((R)-3-{(S)-2-[(S)-2-((S)-2-Acetylamino-3-carboxy-p...)
Affinity DataIC50:  22.3nMAssay Description:Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50366497(CHEMBL1790164)
Affinity DataIC50:  70nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070495(CHEMBL290218 | [(S)-1-((S)-1-Formyl-4-guanidino-bu...)
Affinity DataIC50:  130nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070502(((R)-1-Benzyl-2-{(R)-2-[(S)-4-guanidino-1-(2-oxo-e...)
Affinity DataIC50:  190nMAssay Description:Ability to inhibit Thrombin was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  200nMAssay Description:TP_TRANSPORTER: efflux of Hoechst33342 in BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  400nMAssay Description:TP_TRANSPORTER: efflux of Hoechst33342 in BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCaspase-3(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070499((R)-3-{(S)-2-[(S)-2-((S)-2-Acetylamino-3-carboxy-p...)
Affinity DataIC50:  438nMAssay Description:Amidolytic activity of THP.1 cell lysate against Caspase-3 using C3-Asp-AMC as a substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  500nMAssay Description:TP_TRANSPORTER: inhibition of ATPase activity in BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  900nMAssay Description:TP_TRANSPORTER: efflux of Hoechst33342 in BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
TargetSerine protease 1(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070502(((R)-1-Benzyl-2-{(R)-2-[(S)-4-guanidino-1-(2-oxo-e...)
Affinity DataIC50:  1.76E+3nMAssay Description:Ability to inhibit Trypsin was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070494(CHEMBL36336 | {(R)-1-Benzyl-2-[(R)-2-((R)-1-formyl...)
Affinity DataIC50:  1.79E+3nMAssay Description:Ability to inhibit Trypsin was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  2.00E+3nMAssay Description:Ability to inhibit IL-1 beta converting enzyme was evaluated in LPS-stimulated human whole bloodChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070496((R)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydrox...)
Affinity DataIC50:  2.90E+3nMAssay Description:Ability to inhibit IL-1 beta converting enzyme was evaluated in LPS-stimulated human whole bloodChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070494(CHEMBL36336 | {(R)-1-Benzyl-2-[(R)-2-((R)-1-formyl...)
Affinity DataIC50:  5.44E+3nMAssay Description:Ability to inhibit Thrombin was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50366496(CHEMBL1790166)
Affinity DataIC50:  8.50E+3nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070503(CHEMBL286910 | [(S)-1-((R)-1-Formyl-4-guanidino-bu...)
Affinity DataIC50:  1.25E+4nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50338982((R)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3...)
Affinity DataIC50: >5.00E+4nMAssay Description:TP_TRANSPORTER: efflux of Hoechst33342 in BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50366498(CHEMBL1790165)
Affinity DataIC50:  6.50E+4nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  6.80E+4nMAssay Description:Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  7.00E+4nMAssay Description:Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070497(CHEMBL37975 | {(S)-1-[(S)-4-Guanidino-1-(2-oxo-eth...)
Affinity DataIC50:  1.05E+5nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070496((R)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydrox...)
Affinity DataIC50:  1.42E+5nMAssay Description:Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataIC50:  1.90E+5nMAssay Description:Amidolytic activity of THP.1 cell lysate against Caspase-3 using C3-Asp-AMC as a substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed