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Found 791 with Last Name = 'peng' and Initial = 'w'
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.170nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of N-terminal His-6-tagged recombinant Aurora 1 (62 to 344) (unknown origin) expressed in baculovirus expression system by radiometric ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.740nMAssay Description:Antagonist activity at D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM248056(1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluo...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor expressed in CHO cell membrane measured after 60 mins by scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  3.60nMAssay Description:Antagonist activity at D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM248056(1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluo...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]spiperone from recombinant human D2S receptor expressed in CHO cell membrane measured after 60 mins by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of N-terminal His-6-tagged recombinant Aurora 3 (1 to 309) (unknown origin) expressed in baculovirus expression system by radiometric assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  5.40nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50493380(CHEMBL2425469)
Affinity DataKi:  14nMAssay Description:Mixed-type competitive inhibition of Helicobacter pylori ATCC 43504 urease using urea as substrate by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataKi:  18nMAssay Description:Inhibition of N-terminal His-6-tagged recombinant Aurora 2 (1 to 403) (unknown origin) expressed in baculovirus expression system by radiometric assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50493373(CHEMBL2425478)
Affinity DataKi:  45nMAssay Description:Mixed-type competitive inhibition of Helicobacter pylori ATCC 43504 urease using urea as substrate by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50551638(CHEMBL4790303)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]5-HT from recombinant 5HT1A receptor (unknown origin) expressed in CHO cell membrane measured after 50 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50251187(1-(4-(O-beta-D-Glucopyranosyl) benzylidene) methox...)
Affinity DataKi:  130nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  157nMAssay Description:Antagonist activity at D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50551638(CHEMBL4790303)
Affinity DataKi:  207nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in CHO-K1 cells measured after 15 mins by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM10404((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...)
Affinity DataKi:  450nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50245887(4-((2S,3R,4R,5R)-3,4,5-trihydroxy-tetrahydro-2H-py...)
Affinity DataKi:  510nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50245886(4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymet...)
Affinity DataKi:  730nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50241354(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-(3,4,5-tr...)
Affinity DataKi:  1.00E+3nMAssay Description:Competitive inhibition of LSD1 (unknown origin) using H3Kme2 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50551638(CHEMBL4790303)
Affinity DataKi:  2.16E+3nMAssay Description:Antagonist activity at human D2 receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50300123(2-(4-Formylphenoxy)ethyl dimethyl phosphate | CHEM...)
Affinity DataKi:  3.68E+4nMAssay Description:Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50206197(CHEMBL235565 | methyl 2-(2-(4-formylphenoxy)acetam...)
Affinity DataKi:  5.40E+4nMAssay Description:Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50206195(CHEMBL232590 | methyl 2-(2-(4-formylphenoxy)acetam...)
Affinity DataKi:  1.17E+5nMAssay Description:Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50206194(CHEMBL394901 | methyl 2-(2-(4-formylphenoxy)acetam...)
Affinity DataKi:  1.25E+5nMAssay Description:Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50142796(CHEMBL3759186)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of HDAC1 (unknown origin) preincubated for 15 mins followed by addition of Fluor de Lys as substrate for 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50551625(CHEMBL4776840)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at human D2 receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50551623(CHEMBL4759817)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human D2 receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425864(CHEMBL2312649)
Affinity DataIC50:  2nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50142796(CHEMBL3759186)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts preincubated for 15 mins followed by addition of Fluor de Lys as substrate for 1 hr by fluorom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50551622(CHEMBL4746981)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at human D2 receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50132484(CHEMBL3633769)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory activity against Beta Glucosidase from AlmondsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3K delta (unknown origin) using PIP2 as substrate after 1 hr by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PI3K delta by scintillation proximity radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50551624(CHEMBL4787495)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human D2 receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425870(CHEMBL2311550)
Affinity DataIC50:  3nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50142857(CHEMBL3758839)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts preincubated for 15 mins followed by addition of Fluor de Lys as substrate for 1 hr by fluorom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50142796(CHEMBL3759186)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of HDAC2 (unknown origin) preincubated for 15 mins followed by addition of Fluor de Lys as substrate for 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50132484(CHEMBL3633769)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory concentration against Beta Glucosidase from AlmondsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50551621(CHEMBL4747208)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at human D2 receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-tagged recombinant mouse Aurora A expressed in Sf9 cells using biotin-GLRRASLG as peptide substrate by [gamma-33S]ATP binding assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50148942(CHEMBL3769902)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of PI3K alpha (unknown origin) using PIP2 as substrate after 1 hr by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50132403(CHEMBL3633765)
Affinity DataIC50:  4.5nMAssay Description:Inhibitory concentration against Beta Glucosidase from AlmondsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50142796(CHEMBL3759186)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of HDAC8 (unknown origin) preincubated for 15 mins followed by addition of Fluor de Lys as substrate for 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataIC50:  4.80nMAssay Description:Concentration of compound for 50% displacement of [3H]QNB from Muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50004231(CHEMBL3237167)
Affinity DataIC50:  5nMAssay Description:Inhibition of Aurora A (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50132484(CHEMBL3633769)
Affinity DataIC50:  5.20nMAssay Description:Inhibitory activity against metabotropic glutamate receptor 5 (mGluR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataIC50:  5.20nMAssay Description:Concentration of compound for 50% displacement of [3H]WB-4101 from Alpha-1 adrenergic receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50132345(CHEMBL3633761)
Affinity DataIC50:  5.40nMAssay Description:Binding affinity for prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of PI3K alpha (unknown origin) using PIP2 as substrate after 1 hr by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
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