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Found 544 with Last Name = 'sanchez' and Initial = 'm'
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Dipartimento Di Chimica

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of human recombinant ACE by fluorimetryMore data for this Ligand-Target Pair
LigandPNGBDBM50381156(CHEMBL2018220 | D3RKN_94)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381161(CHEMBL2018219)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  1nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
LigandPNGBDBM50450513(CHEMBL4168219)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 or HEK MSR2 cells assessed as inhibition of PF-04674114-induced Ca2+ flux pre-incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365882(CHEMBL1957870)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381157(CHEMBL2018360)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365868(CHEMBL1957857)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24347(N-hydroxy-N'-[4-(1-phenyl-1H-1,2,3-triazol-4-yl)ph...)
Affinity DataIC50:  1.30nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381164(CHEMBL2018214)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381158(CHEMBL2018222)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381158(CHEMBL2018222)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381162(CHEMBL2018221)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365868(CHEMBL1957857)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381161(CHEMBL2018219)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PI3K beta-mediated AKT phosphorylation at serine 473 in PTEN deficient human MDA-MB-468 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381165(CHEMBL2018215)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50502640(CHEMBL4470585)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human TRPV4More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24346(N-(4-{1-[(4-fluorophenyl)methyl]-1H-1,2,3-triazol-...)
Affinity DataIC50:  1.90nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24352(N-(3-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,...)
Affinity DataIC50:  1.90nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365867(CHEMBL1957856)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  2nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381159(CHEMBL2018217)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381159(CHEMBL2018217)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365869(CHEMBL1957858)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381163(CHEMBL2018361)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50450500(CHEMBL4164465)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 or HEK MSR2 cells assessed as inhibition of PF-04674114-induced Ca2+ flux pre-incubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50450500(CHEMBL4164465)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 or HEK MSR2 cells assessed as inhibition of PF-04674114-induced Ca2+ flux pre-incubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50381155(CHEMBL2018216)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24350(N-(3-{1-[(4-fluorophenyl)methyl]-1H-1,2,3-triazol-...)
Affinity DataIC50:  2.60nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24352(N-(3-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,...)
Affinity DataIC50:  2.70nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381158(CHEMBL2018222)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PI3K beta-mediated AKT phosphorylation at serine 473 in PTEN deficient human MDA-MB-468 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381158(CHEMBL2018222)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PI3K beta-mediated AKT phosphorylation at serine 473 in PTEN deficient human MDA-MB-468 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24360(N-(3-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,...)
Affinity DataIC50:  2.80nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365882(CHEMBL1957870)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kdelta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365866(CHEMBL1957855)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365865(CHEMBL1957841)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24353(N-[4-(1-benzyl-1H-1,2,3-triazol-5-yl)phenyl]-N'-hy...)
Affinity DataIC50:  3.10nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381158(CHEMBL2018222)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24349(N-[3-(1-benzyl-1H-1,2,3-triazol-4-yl)phenyl]-N'-hy...)
Affinity DataIC50:  3.10nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at human TRPV4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24357(N-[3-(1-benzyl-1H-1,2,3-triazol-5-yl)phenyl]-N'-hy...)
Affinity DataIC50:  3.30nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381159(CHEMBL2018217)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of PI3K beta-mediated AKT phosphorylation at serine 473 in PTEN deficient human MDA-MB-468 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50505551(CHEMBL4517101)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at BacMam virus expressing human TRPV4 transduced in BHK/AC9 or HEK MSR2 cells assessed as inhibition of GSK634775-induced Ca2+ f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24355(N-hydroxy-N'-[4-(1-phenyl-1H-1,2,3-triazol-5-yl)ph...)
Affinity DataIC50:  3.5nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50505543(CHEMBL4454801)
Affinity DataIC50:  3.80nMAssay Description:Antagonist activity at BacMam virus expressing human TRPV4 transduced in BHK/AC9 or HEK MSR2 cells assessed as inhibition of GSK634775-induced Ca2+ f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24358(N-(3-{1-[(4-fluorophenyl)methyl]-1H-1,2,3-triazol-...)
Affinity DataIC50:  3.80nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM24350(N-(3-{1-[(4-fluorophenyl)methyl]-1H-1,2,3-triazol-...)
Affinity DataIC50:  4nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Illinois At Chicago

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365873(CHEMBL1957862)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kbeta by time-resolved FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381162(CHEMBL2018221)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of PI3K beta-mediated AKT phosphorylation at serine 473 in PTEN deficient human MDA-MB-468 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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