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Found 24 with Last Name = 'yonemoto' and Initial = 'm'
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50038096((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50:  0.240nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285068((S)-2-{[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50:  0.520nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403481(CHEMBL2115091)
Affinity DataIC50:  0.730nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285065((S)-2-{[(1S,2S)-2-Biphenyl-4-yl-3-(3,4-dichloro-ph...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285069((S)-2-{[(1S,2S)-2-Biphenyl-4-yl-3-(4-chloro-phenyl...)
Affinity DataIC50:  3.20nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062251(CHEMBL285263 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062250(CHEMBL36407 | trisodium 5-[2-benzo[d][1,3]dioxol-5...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062249(CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062249(CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of Farnesyltransferase in competitive manner with respect to FPP (farnesyl diphosphate) at 0.6 microM FPP and 0.36 microM Ras peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062252(CHEMBL36339 | trisodium 5-[2-benzo[d][1,3]dioxol-5...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062248(CHEMBL36515 | trisodium 5-[2-benzo[d][1,3]dioxol-5...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062249(CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of Farnesyltransferase in competitive manner with respect to FPP (farnesyl diphosphate) at 0.6 microM FPP and 3.6 microM Ras peptide.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062256(CHEMBL284073 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285066((R)-2-{[(1R,2R)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285067((R)-2-{[(1R,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062258(2-{[((E)-2-Benzo[1,3]dioxol-5-yl-5-benzooxazol-2-y...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062257(2-({[(E)-5-Benzooxazol-2-yl-2-(4-chloro-phenyl)-1-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062249(CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of FTase in competitive manner with respect to FPP (farnesyl diphosphate) at 6.0 microM FPP and 0.36 microM Ras peptide.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062253(2-({[(E)-2-(4-Chloro-phenyl)-1-methyl-5-naphthalen...)
Affinity DataIC50:  51nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285066((R)-2-{[(1R,2R)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50: >300nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285068((S)-2-{[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50: >300nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285064(2-{[2,3-Bis-(4-chloro-phenyl)-1-methyl-propylcarba...)
Affinity DataIC50:  660nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062255(2-({[2,3-Bis-(4-chloro-phenyl)-1-methyl-propyl]-na...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062254(2-({[2,3-Bis-(4-chloro-phenyl)-1-methyl-propyl]-me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed