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Target
Squalene synthase
Ligand
BDBM50403481
Substrate
n/a
Meas. Tech.
ChEBML_201928
IC50
0.730000±n/a nM
Citation
 Iwasawa, Y; Hayashi, M; Nomoto, T; Shibata, J; Mitsuya, M; Hirota, K; Yonemoto, M; Kamei, T; Miura, K; Tomimoto, K Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase Bioorg Med Chem Lett 5:1989-1994 (1995)    Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48114.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1352847
Residue:
417
Sequence:
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
  
Inhibitor
Name:
BDBM50403481
Synonyms:
CHEMBL2115091
Type:
Small organic molecule
Emp. Form.:
C28H26Cl2FNO5
Mol. Mass.:
546.414
SMILES:
C[C@H](NC(=O)C[C@H](CC(O)=O)C(O)=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)c1ccc(c(F)c1)-c1ccccc1
Structure:
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