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Found 171 with Last Name = 'shibata' and Initial = 'j'
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50038096((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50:  0.240nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285068((S)-2-{[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50:  0.520nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285068((S)-2-{[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50:  0.520nMAssay Description:Inhibitory activity of the compound against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403481(CHEMBL2115091)
Affinity DataIC50:  0.730nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285065((S)-2-{[(1S,2S)-2-Biphenyl-4-yl-3-(3,4-dichloro-ph...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192076(1-{5-[((S)-5-chloro-indan-2-ylamino)-methyl]-1H-py...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288819((R)-4-[(E)-(1S,2S)-2-(3,4-Dichloro-benzyl)-1-methy...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity of the compound against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285069((S)-2-{[(1S,2S)-2-Biphenyl-4-yl-3-(4-chloro-phenyl...)
Affinity DataIC50:  3.20nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192074(22-hydroxy-15-oxa-8-thia-9,21,23-triazapentacyclo[...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062250(CHEMBL36407 | trisodium 5-[2-benzo[d][1,3]dioxol-5...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062251(CHEMBL285263 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288818((R)-4-[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluoro...)
Affinity DataIC50:  3.90nMAssay Description:Inhibitory activity of the compound against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062249(CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062249(CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of Farnesyltransferase in competitive manner with respect to FPP (farnesyl diphosphate) at 0.6 microM FPP and 0.36 microM Ras peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062252(CHEMBL36339 | trisodium 5-[2-benzo[d][1,3]dioxol-5...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192073(22-hydroxy-15-oxa-8-thia-9,12,21,23-tetraazapentac...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192075(3-(2-cyclopentyl-3-oxo-2,3-dihydro-benzo[d]isothia...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062248(CHEMBL36515 | trisodium 5-[2-benzo[d][1,3]dioxol-5...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062249(CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of Farnesyltransferase in competitive manner with respect to FPP (farnesyl diphosphate) at 0.6 microM FPP and 3.6 microM Ras peptide.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186375(CHEMBL210540 | N-(5-(2-(cyclohexyloxy)-6-methylpyr...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of CDK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062256(CHEMBL284073 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50186375(CHEMBL210540 | N-(5-(2-(cyclohexyloxy)-6-methylpyr...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192077(23-hydroxy-16-oxa-8-thia-9,22,24-triazapentacyclo[...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192082(22-hydroxy-12-methyl-15-oxa-8-thia-9,12,21,23-tetr...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Affinity DataIC50:  12nMAssay Description:Inhibition of CDK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50186374(CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyr...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192080(9-methyl-8,9,10,11-tetrahydro-7H-16,18-(epiminomet...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285066((R)-2-{[(1R,2R)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285067((R)-2-{[(1R,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062258(2-{[((E)-2-Benzo[1,3]dioxol-5-yl-5-benzooxazol-2-y...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  24nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186374(CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyr...)
Affinity DataIC50:  26nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062257(2-({[(E)-5-Benzooxazol-2-yl-2-(4-chloro-phenyl)-1-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192072((15S)-16-oxa-8,9,12,22,24-pentaazahexacyclo[15.6.2...)
Affinity DataIC50:  29nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50186376(CHEMBL427045 | N-(5-(2-(cyclohexyloxy)-6-methylpyr...)
Affinity DataIC50:  34nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM6619(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Affinity DataIC50:  42nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062249(CHEMBL285434 | trisodium 5-[2-benzo[d][1,3]dioxol-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of FTase in competitive manner with respect to FPP (farnesyl diphosphate) at 6.0 microM FPP and 0.36 microM Ras peptide.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062253(2-({[(E)-2-(4-Chloro-phenyl)-1-methyl-5-naphthalen...)
Affinity DataIC50:  51nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM6619(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Affinity DataIC50:  71nMAssay Description:Inhibition of CDK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM6619(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM6619(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Affinity DataIC50:  122nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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