Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 15 hits in this display
BDBM404273(US10017502, Example 6b)
BDBM404273(US10017502, Example 6b)
BDBM404273(US10017502, Example 6b)
IC50: 10nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
BDBM404271(US10017502, Example 6a)
BDBM238163(US10017502, Example 6 | US9394291, 6 | US9394291, ...)
BDBM404273(US10017502, Example 6b)
IC50: 32nMAssay Description:Antagonist activity at full length human mineralocorticoid receptor expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
BDBM238163(US10017502, Example 6 | US9394291, 6 | US9394291, ...)
BDBM238163(US10017502, Example 6 | US9394291, 6 | US9394291, ...)
IC50: 58nMAssay Description:Test A1 and A2: In order to identify binding to the human MR LBD a scintillation proximity assay (SPA) was adapted to the 384-well format. The MR-LBD...More data for this Ligand-Target Pair
BDBM404273(US10017502, Example 6b)
IC50: 79nMAssay Description:Antagonist activity at gal4-fused human mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
BDBM238163(US10017502, Example 6 | US9394291, 6 | US9394291, ...)
IC50: 82nMpH: 7.5Assay Description:Test A1: Briefly, in Test A1 the assay was run in 384 well format in 10 mM Tris-HCl, pH 7.5, 0.5 mM EDTA 20 mM NaMoO4, 0.1 mM DTT and 10% glycerol at...More data for this Ligand-Target Pair
BDBM238163(US10017502, Example 6 | US9394291, 6 | US9394291, ...)
IC50: 82nMAssay Description:Test A1 and A2: In order to identify binding to the human MR LBD a scintillation proximity assay (SPA) was adapted to the 384-well format. The MR-LBD...More data for this Ligand-Target Pair
BDBM238163(US10017502, Example 6 | US9394291, 6 | US9394291, ...)
IC50: 1.90E+3nMpH: 7.5Assay Description:Test A1: Briefly, in Test A1 the assay was run in 384 well format in 10 mM Tris-HCl, pH 7.5, 0.5 mM EDTA 20 mM NaMoO4, 0.1 mM DTT and 10% glycerol at...More data for this Ligand-Target Pair
BDBM404273(US10017502, Example 6b)
IC50: 1.90E+3nMAssay Description:Test A1 and A2: In order to identify binding to the human MR LBD a scintillation proximity assay (SPA) was adapted to the 384-well format. The MR-LBD...More data for this Ligand-Target Pair
BDBM404273(US10017502, Example 6b)
BDBM404273(US10017502, Example 6b)