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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Neurosearch Sweden
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
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Affinity Data
Ki: 0.0400nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Neurosearch Sweden
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
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Affinity Data
Ki: 0.100nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cells
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Neurosearch Sweden
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.600nM
Assay Description:
Displacement of [3H]raclopride from human D2 dopamine receptor expressed in CHO cell membranes
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Pierre Fabre Research Center
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
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Affinity Data
Ki: 1.5nM
Assay Description:
Displacement of [3H]YM-09151-2 from rat striatum D2 receptor
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Neurosearch Sweden
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.20nM
Assay Description:
Binding affinity for dopamine receptor D2 determined using [3H]-spiperone
More data for this Ligand-Target Pair
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PubMed
Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Neurosearch Sweden
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.20nM
Assay Description:
Agonist activity at dopamine D2 receptor
More data for this Ligand-Target Pair
Target Info
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KEGG
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antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Neurosearch Sweden
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
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Affinity Data
Ki: 2.30nM
Assay Description:
Displacement of [3H]nemonapride from dopamine D2L receptor (unknown origin) expressed in African green monkey COS7 cells
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
King Fahd University of Petroleum & Minerals
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
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Affinity Data
Ki: 7.19nM ΔG°: -48.3kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Neurosearch Sweden
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.81nM ΔG°: -46.0kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Human-cloned dopamine D2L receptors stably expressed in C6 rat glioma cells (kindly donated by Professor Roberto Maggio, Università di L'Aquil...
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
King Fahd University of Petroleum & Minerals
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
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Affinity Data
Ki: 9.30nM
Assay Description:
Agonist activity at 5HT1A receptor
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
King Fahd University of Petroleum & Minerals
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.30nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligand
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Pierre Fabre Research Center
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 65nM
Assay Description:
Displacement of [3H]OH-DPAT from rat cortex 5HT1A receptor
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Pierre Fabre Research Center
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
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Affinity Data
Ki: 3.31E+3nM
Assay Description:
Displacement of [3H]ketanserin from rat cortex 5HT2A receptor
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Neurosearch Sweden
Curated by
ChEMBL
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.90nM
Assay Description:
Antagonist activity at human D2 dopamine receptor expressed in CHO cell membrane by GTPgammaS-binding assay
More data for this Ligand-Target Pair
Target Info
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CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
King Fahd University of Petroleum & Minerals
Ligand
BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 324nM
Assay Description:
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
More data for this Ligand-Target Pair
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