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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
101
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Target
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: 94nM
Assay Description:
Inhibition of recombinant human IDO1 expressed in Escherichia coli assessed as reduction in formation of N-formylkynurenine by measuring apparent inh...
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Target
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: 94nM
Assay Description:
Inhibition of human recombinant IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after 10 mins by...
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Target
Urease subunit beta
(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Wroc?Aw University Of Technology
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: 226nM
Assay Description:
Inhibition of recombinant Helicobacter pylori urease expressed in Escherichia coli rosetta DE3 after 120 mins by Berthelot colorimetric analysis
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Target
Thioredoxin reductase
(Escherichia coli (strain K12))
Thioredoxin Systems
US Patent
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: 300nM IC50: 6.00E+3nM
Assay Description:
All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...
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Target
Macrophage migration inhibitory factor
(Homo sapiens (Human))
Ecole Polytechnique FÉDÉRale De Lausanne
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: 570nM IC50: 2.40E+3nM
pH: 6.5
Assay Description:
The assay principle is based on measuring the absorbance of D-dopachrome methyl ester (red), which is transformed by enzymatically active MIF to the ...
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Macrophage migration inhibitory factor
(Homo sapiens (Human))
Ecole Polytechnique FÉDÉRale De Lausanne
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: 570nM
Assay Description:
Inhibition of recombinant human MIF tautomerization expressed in Escherichia coli BL21/DE3 using HPP as substrate preincubated for 15 mins followed b...
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Target
Neutrophil cytosol factor 1
(Homo sapiens)
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: 1.20E+4nM
Assay Description:
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...
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Neutrophil cytosol factor 1
(Homo sapiens)
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: 6.30E+4nM
Assay Description:
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...
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Target
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: 9.40E+4nM
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Target
Neutrophil cytosol factor 1
(Homo sapiens)
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Ki: >3.00E+5nM
Assay Description:
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...
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Target
Insulin-degrading enzyme
(Homo sapiens (Human))
Univ. Lille
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 14nM
Assay Description:
Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...
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UDP-glucose 4-epimerase
(Homo sapiens (Human))
University Of Dundee
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 14nM
Assay Description:
Inhibition of human GalE by HPAEC assay
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Toxin B
(Peptoclostridium difficile)
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 17nM
Assay Description:
Inhibition of Clostridium difficile toxin B
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 30nM
Assay Description:
Primary assay principle based on quenched FRET peptide substrate of SARS-CoV-2 3CL-Pro (lhs). Inhibiting compounds reduce fluorescence signal relativ...
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Target
Insulin-degrading enzyme
(Homo sapiens (Human))
Univ. Lille
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 42nM
Assay Description:
Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...
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Target
Structural capsid protein
(Human immunodeficiency virus 1)
Shandong University
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 47nM
Assay Description:
Inhibition of HIV 1 capsid CTD dimerization incubated for 5 hrs by TR-FRET assay
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 80nM
Assay Description:
Primary assay principle based on quenched FRET peptide substrate of SARS-CoV-2 3CL-Pro (lhs). Inhibiting compounds reduce fluorescence signal relativ...
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UDP-N-acetylglucosamine 1-carboxyvinyltransferase
(Haemophilus influenzae (G-proteobacteria))
University Of Ljubljana
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 100nM
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Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 110nM
Assay Description:
Inhibition of hexa-His-tagged human soluble epoxide hydrolase C-terminal hydrolase domain expressed in Escherichia coli BL21(DE3) pre-incubated for 3...
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Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 110nM
Assay Description:
Inhibition of hexa-His-tagged human soluble epoxide hydrolase C-terminal hydrolase domain expressed in Escherichia coli BL21(DE3) pre-incubated for 3...
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Target
Phosphoethanolamine/phosphocholine phosphatase
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 111nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
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Mannose-6-phosphate isomerase
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 190nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 240nM
Assay Description:
Inhibition of SARS CoV-2 PL protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 substrate by FRET assay
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Target
Mevalonate kinase
(Streptococcus pneumoniae D39)
Srmlsc
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 287nM
Assay Description:
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...
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Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 300nM
Assay Description:
Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...
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Target
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 300nM
Assay Description:
Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...
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L,D-transpeptidase 2
(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
TBA
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 360nM
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Neutrophil cytosol factor 1 [S99G]
(Homo sapiens (Human))
Emory University
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 390nM
Assay Description:
NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Susan Smith, Emory Univers...
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Mannose-6-phosphate isomerase
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: <391nM
pH: 7.4 T: 2°C
Assay Description:
The purpose of this assay is to identify non-competititve inhibitors of human PMI. This is accomplished by using a G6PD- NADPH-coupled assay. In the ...
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Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human))
Radboud University
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 400nM
Assay Description:
Inhibition of wild type recombinant human histone lysine methyltransferase G9a (913 to 1193 residues) expressed in Escherichia coli Rosetta BL21 DE3 ...
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Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 420nM
Assay Description:
Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...
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Target
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 420nM
Assay Description:
Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...
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Pantothenate synthetase
(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Srmlsc
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 485nM
Assay Description:
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...
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Diphosphomevalonate decarboxylase
(Streptococcus pneumoniae D39)
Srmlsc
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 513nM
Assay Description:
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 520nM
Assay Description:
This is a review article. Please point to the original journal.
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Mevalonate kinase
(Streptococcus pneumoniae D39)
Srmlsc
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
This is a review article.
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Recombinant SARS-CoV-2 Mpro with native N and C termini was expressed in Escherichia coli, and subsequently purified (Extended Data Fig. 1a, b). The ...
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 670nM
Assay Description:
This is a review article. Please point to the original journal.
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Inhibition of SARS CoV-2 3CL protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 substrate by FRET assay
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Target
Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Inhibition of SARS-CoV-2 MPro expressed in Escherichia coli BL21 (DE3) using Mca-AVLQ SGFR-K(Dnp)K as substrate by EnVision multimode plate reader an...
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Target
Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Inhibition of SARS-CoV-2 MPro
More data for this Ligand-Target Pair
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Target
Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli BL21 (DE3) using Mca-AVLQSGFRK(Dnp)K as substrate by fluorescence assay
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Target
Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Inhibition of SARS-CoV-2 main protease
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Target
Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Inhibition of SARS-CoV2 main protease
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
Assay Description:
Antagonistic activity against beta-2 adrenergic receptor on isolated guinea pig tracheal strips
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Target
Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 670nM
More data for this Ligand-Target Pair
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Target
Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 670nM
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Target
Phosphomannomutase 2
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 672nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
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Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 690nM
Assay Description:
Inhibition of human BBOX pre-incubated for 1 min using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
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Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 710nM
Assay Description:
Inhibition of human BBOX pre-incubated for 10 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
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Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 720nM
Assay Description:
Inhibition of human BBOX pre-incubated for 25 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
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Histone-lysine N-methyltransferase EHMT1
(Homo sapiens (Human))
Radboud University
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 730nM
Assay Description:
Inhibition of wild type recombinant human histone lysine methyltransferase GLP (951 to 1235 residues) expressed in Escherichia coli Rosetta BL21 DE3 ...
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Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 760nM
Assay Description:
Inhibition of human BBOX pre-incubated for 15 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
More data for this Ligand-Target Pair
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Target
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 830nM
Assay Description:
Inhibition of human BBOX pre-incubated for 20 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
More data for this Ligand-Target Pair
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Mitochondrial import inner membrane translocase subunit TIM23
(Saccharomyces cerevisiae S288c)
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 880nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...
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Phosphotransferase
(Trypanosoma brucei)
University Of Pittsburgh
Curated by
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Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 901nM
Assay Description:
Excerpt from MH082340 application (Dr. James Morris, Clemson University) Trypanosoma brucei, the digenic protozoan parasite that causes African sleep...
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Perilipin-5
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...
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Eukaryotic translation initiation factor 4 gamma 1
(Homo sapiens (Human))
Emory University
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 1.15E+3nM
Assay Description:
Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...
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Histone deacetylase 6
(Homo sapiens (Human))
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 1.20E+3nM
Assay Description:
Inhibition of human recombinant HDAC8 using RHKAcKAc-AMC substrate by fluorescence based assay
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Genome polyprotein
(Hepatitis C virus)
University Of Wisconsin-Milwaukee
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 1.40E+3nM
pH: 7.5 T: 2°C
Assay Description:
Binding assays containing 25 mM MOPS pH 7.5, 1.25 mM MgCl2, 20 nM Cy5-dT15, and 200 nM NS3h_1b were incubated 5 min at RT. Following addition of indi...
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Beta-arrestin-1
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 1.52E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: 1 R03 DA031665-01A1 Project Title: MLP Assay for Arrestin-AP2 Inhibitors Assay Provider: Er...
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Pantothenate synthetase
(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Srmlsc
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 1.56E+3nM
Assay Description:
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 2.02E+3nM
Assay Description:
Inhibition of SARS-CoV-2 papain-like protease preincubated for 60 mins
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Prostaglandin G/H synthase 1
(Bos taurus)
Johannes Gutenberg University
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 2.10E+3nM
Assay Description:
Inhibition of bovine COX1
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Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonat...
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 2.26E+3nM
Assay Description:
Inhibition of SARS CoV-2 PL protease incubated for 60 mins
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Macrophage migration inhibitory factor
(Homo sapiens (Human))
Ecole Polytechnique FÉDÉRale De Lausanne
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 2.40E+3nM
Assay Description:
Inhibition of recombinant human MIF tautomerization expressed in Escherichia coli BL21/DE3 using dopa as substrate
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Microtubule-associated protein 2
(Homo sapiens (Human))
Wroclaw University Of Technology
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 2.43E+3nM
Assay Description:
Non-covalent/mixed type inhibition of recombinant human MetAP2 using Met-AMC as substrate preincubated for 30 mins followed by substrate addition by ...
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Histone deacetylase 5
(Homo sapiens (Human))
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 3.40E+3nM
Assay Description:
Inhibition of human recombinant HDAC5 using acetyl-Lys(trifluoroacetyl)-AMC substrate by fluorescence based assay
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Perilipin-1
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 3.41E+3nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...
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Urease subunit beta
(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Wroc?Aw University Of Technology
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 3.69E+3nM
Assay Description:
Inhibition of urease in Helicobacter pylori J99 in Brucella broth using urea as substrate preincubated for 2 hrs followed by substrate addition measu...
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Histone deacetylase 9
(Homo sapiens (Human))
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 3.70E+3nM
Assay Description:
Inhibition of human recombinant HDAC9 using acetyl-Lys(trifluoroacetyl)-AMC substrate by fluorescence based assay
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Urease subunit beta
(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Wroc?Aw University Of Technology
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 3.80E+3nM
Assay Description:
Inhibition of recombinant Helicobacter pylori urease expressed in Escherichia coli rosetta DE3 using urea as substrate assessed as transformed cell u...
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dTDP-4-dehydrorhamnose 3,5-epimerase
(Mycobacterium tuberculosis H37Rv)
Pcmd
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 4.00E+3nM
Assay Description:
Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Michael McNeil, Colorado State Universi...
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Caspase-1
(Homo sapiens (Human))
Depaul University
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 4.04E+3nM
pH: 7.5 T: 2°C
Assay Description:
All assays were performed at 100 µL total volume in triplicate and monitored for 60 minutes at room temperature in a 96-well plate format in HEPES Bu...
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Lysine-specific demethylase 5B
(Homo sapiens (Human))
TBA
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 5.00E+3nM
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Sulfhydryl oxidase 1
(Homo sapiens)
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 5.40E+3nM
Assay Description:
Inhibition of N-terminal poly-histidine tagged recombinant QSOX1 (33 to 546 residues) (unknown origin) expressed in Rosetta-gami B (DE3) cells using ...
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Sulfhydryl oxidase 1
(Homo sapiens)
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 5.40E+3nM
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Histone deacetylase 6
(Homo sapiens (Human))
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 6.90E+3nM
Assay Description:
Inhibition of human recombinant HDAC6 using RHKKAc-AMC substrate by fluorescence based assay
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Mitochondrial import inner membrane translocase subunit TIM10
(Saccharomyces cerevisiae S288c)
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 1.00E+4nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...
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Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: <1.00E+4nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Cholinesterase
(Equus caballus (Horse))
Sun Yat-Sen University
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 1.04E+4nM
Assay Description:
Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured ever...
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Cholinesterase
(Equus caballus (Horse))
Sun Yat-Sen University
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 1.06E+4nM
Assay Description:
Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate additi...
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Histone deacetylase 6
(Homo sapiens (Human))
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 1.15E+4nM
Assay Description:
Inhibition of recombinant human HDAC6 using fluorogenic HDAC substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...
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DNA-directed RNA polymerase subunit beta
(Escherichia coli)
Pcmd
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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IC50: 1.17E+4nM
Assay Description:
Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...
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Large T antigen
(Simian virus 40)
Southern Research Specialized Biocontainment Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 1.39E+4nM
Assay Description:
A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag Southern Re...
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Acetylcholinesterase
(Electrophorus electricus (Electric eel))
Sun Yat-Sen University
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: >1.50E+4nM
Assay Description:
Inhibition of electric eel acetylcholinesterase using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition...
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Acetylcholinesterase
(Electrophorus electricus (Electric eel))
Sun Yat-Sen University
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 4.10E+4nM
Assay Description:
Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every ...
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Urease subunit beta
(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Wroc?Aw University Of Technology
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 4.54E+4nM
Assay Description:
Inhibition of urease in Helicobacter pylori J99 in Brucella broth using urea as substrate after 2 hrs by Berthelot assay
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Gag-Pol polyprotein
(Human immunodeficiency virus type 1 group M subtyp...)
University Of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: >5.00E+4nM
pH: 8.0 T: 2°C
Assay Description:
A fluorescence resonance energy transfer assay is developed in 96-well and 384-well microplate formats with robotic manipulation to enable high-throu...
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Urease subunit beta
(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Wroc?Aw University Of Technology
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 6.90E+4nM
Assay Description:
Inhibition of recombinant Helicobacter pylori urease expressed in Escherichia coli rosetta DE3 using urea as substrate assessed as transformed cell u...
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Insulin-degrading enzyme
(Homo sapiens (Human))
Univ. Lille
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human recombinant IDE harboring C110L/C171S/C178A/C257V/C414L/C573N/C590S/C789S/C812A/C819A/C904S/C966N/C974A mutant expressed in Esche...
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Target
Mevalonate kinase
(Streptococcus pneumoniae D39)
Srmlsc
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
IC50: 1.01E+5nM
Assay Description:
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...
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Target Info
PDB
MMDB
KEGG
UniProtKB/TrEMBL
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GoogleScholar
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Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
EC50: 4.67E+3nM
Assay Description:
This is a review article. Please point to the original journal.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
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Target
Hexokinase HKDC1 [W721R]
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
EC50: 3.88E+4nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
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Target
Hexokinase-1
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
EC50: 4.19E+4nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Target
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Kd: 3.60E+3nM
Assay Description:
Binding affinity to human BBOX by tryptophan fluorescence quenching binding assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MCE
PC cid
PC sid
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In Depth
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Article
PubMed
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Target
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
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Affinity Data
Kd: 4.60E+3nM
Assay Description:
Binding affinity to human BBOX in presence of Fe(II) by tryptophan fluorescence quenching binding assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Replicase polyprotein 1ab
(2019-nCoV)
Fraunhofer Institute For Translational Medicine And Pharmacology (Itmp) And Fraunhofer Cluster Of Excellence For Immune Mediated Diseases (Cimd
Ligand
BDBM34233
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 4.67E+3nM
Assay Description:
This is a review article.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
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Article
PubMed
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