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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
17
hits in this display
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
E£Tv£S Lor£Nd University
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
Ki: 1.00E+3nM
Assay Description:
Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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PubMed
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Target
Cathepsin B
(Homo sapiens (Human))
University Of Ljubljana
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
Ki: 3.95E+4nM
Assay Description:
Mixed inhibition of recombinant human cathepsin B endopeptidase activity assessed as inhibitory constant for enzyme-substrate-inhibitor complex using...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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ChEBI
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PDB
3D Structure (crystal)
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Target
Cathepsin B
(Homo sapiens (Human))
University Of Ljubljana
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
Ki: 3.95E+4nM
Assay Description:
Mixed inhibition of cathepsin B (unknown origin) endopeptidase activity assessed as inhibition constant for enzyme-substrate-inhibitor complex
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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ChEBI
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PDB
3D Structure (crystal)
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Target
Cathepsin B
(Homo sapiens (Human))
University Of Ljubljana
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
Ki: 1.54E+5nM
Assay Description:
Mixed inhibition of recombinant human cathepsin B endopeptidase activity assessed as inhibitory constant for enzyme-inhibitor complex using Z-Arg-Arg...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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ChEBI
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PubMed
PDB
3D Structure (crystal)
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Target
Cathepsin B
(Homo sapiens (Human))
University Of Ljubljana
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Copy SMILES
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Affinity Data
Ki: 1.54E+5nM
Assay Description:
Mixed inhibition of cathepsin B (unknown origin) endopeptidase activity assessed as inhibition constant for enzyme-inhibitor complex
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
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MCE
PC cid
PC sid
PDB
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In Depth
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Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cathepsin B
(Homo sapiens (Human))
University Of Ljubljana
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
Ki: 2.72E+5nM
Assay Description:
Non-competitive inhibition of recombinant human cathepsin B exopeptidase activity assessed as inhibitory constant for enzyme-inhibitor complex using ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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ChEBI
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PubMed
PDB
3D Structure (crystal)
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Target
Cathepsin B
(Homo sapiens (Human))
University Of Ljubljana
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Copy SMILES
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Affinity Data
Ki: 2.72E+5nM
Assay Description:
Noncompetitive inhibition of cathepsin B (unknown origin) exopeptidase activity assessed as inhibition constant for enzyme-inhibitor complex
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
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MCE
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PC sid
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Article
PubMed
PDB
3D Structure (crystal)
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Target
Methionine aminopeptidase 2
(Homo sapiens (Human))
Northern Illinois University
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
IC50: 55nM
Assay Description:
Inhibition of human methionine aminopeptidase 2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Target
Methionine aminopeptidase 2
(Homo sapiens (Human))
Northern Illinois University
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
IC50: 55nM
Assay Description:
Inhibition of recombinant human N-terminal His-tagged MetAP2 expressed in baculovirus infected BTI-TN-5B1-4 insect cells using Met-Pro-pNA as substra...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
IC50: 980nM
Assay Description:
Inhibition of BRD4 in human MV4-11 cells using biotin labelled N-C:SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K as substrate preincubated for 15...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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ChEBI
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Article
PubMed
PDB
3D Structure (crystal)
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
IC50: 980nM
Assay Description:
Inhibition of BRD4 BD1 (unknown origin) using biotin labelled NeC: SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K as substrate preincubated for 15...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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ChEBI
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MCE
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PDB
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In Depth
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Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cystathionine gamma-lyase
(Homo sapiens (Human))
Shanghai Jiao Tong University
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
IC50: 6.00E+3nM
Assay Description:
Inhibition of human CSE using H-Cys as the substrate by LC/MS/MS-based assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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ChEBI
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PubMed
Copy BDB DOI
Target
Cystathionine gamma-lyase
(Homo sapiens (Human))
Shanghai Jiao Tong University
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
IC50: 8.00E+3nM
Assay Description:
Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Purchase
ChEBI
DrugBank
MCE
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cystathionine gamma-lyase
(Homo sapiens (Human))
Shanghai Jiao Tong University
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.07E+4nM
Assay Description:
Inhibition of human CSE using H-Cys as the substrate by tandem well based HTS assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
DrugBank
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PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Methionine aminopeptidase 1
(Homo sapiens (Human))
Northern Illinois University
Curated by
ChEMBL
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
IC50: >1.50E+4nM
Assay Description:
Inhibition of human methionine aminopeptidase 1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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ChEBI
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MCE
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PC sid
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Article
PubMed
DrugBank
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Target
Vacuolar aminopeptidase 1
(Saccharomyces cerevisiae)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
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Affinity Data
EC50: 607nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
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ChEBI
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PC sid
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PCBioAssay
Copy BDB DOI
Target
Vacuolar aminopeptidase 1
(Saccharomyces cerevisiae)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM64987
(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 752nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
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ChEBI
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MCE
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