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Found 241 Enz. Inhib. hit(s) with Target = 'Calpain-2'
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50503849(CHEMBL4590466)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant porcine calpain 2 protease using BODIPY-FL casein as substrate measured at 30 secs time interval for 30 mins by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189833((S)-N-butyl-3-((S)-2-(4-fluorophenylsulfonamido)-3...)
Affinity DataIC50:  21nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25891((2S)-2-[(5-formyl-1H-pyrrol-2-yl)formamido]-3-meth...)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50503846(CHEMBL4540394)
Affinity DataIC50:  27nMAssay Description:Inhibition of recombinant porcine calpain 2 protease using BODIPY-FL casein as substrate measured at 30 secs time interval for 30 mins by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358153(CHEMBL1921830)
Affinity DataIC50:  30nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358153(CHEMBL1921830)
Affinity DataIC50:  30nMAssay Description:Inhibition of calpain-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50503847(CHEMBL4574306)
Affinity DataIC50:  34nMAssay Description:Inhibition of recombinant porcine calpain 2 protease using BODIPY-FL casein as substrate measured at 30 secs time interval for 30 mins by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50114340((S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-for...)
Affinity DataIC50:  49nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50284777(CHEMBL36969 | Z-Phe-Tyr(Bu)-H)
Affinity DataIC50:  80nMAssay Description:Compound was tested for its inhibitory activity against calpain 2More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25890((2S)-2-[(5-formylthiophen-2-yl)formamido]-3-methyl...)
Affinity DataIC50:  85nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358152(CHEMBL1921829)
Affinity DataIC50:  85nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50263559(((1S)-1-((((1S)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2,3-...)
Affinity DataIC50:  99nMAssay Description:Inhibition of pig kidney m-calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50263560(2-methoxyethyl (S)-1-((S)-4-(cyclopropylamino)-3,4...)
Affinity DataIC50:  100nMAssay Description:Inhibition of pig kidney m-calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25892((2S)-2-[(4-formyl-1H-pyrrol-2-yl)formamido]-3-meth...)
Affinity DataIC50:  100nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25887((2S)-3-methyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-2...)
Affinity DataIC50:  100nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25889((2S)-2-[(5-formylfuran-2-yl)formamido]-3-methyl-N-...)
Affinity DataIC50:  100nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50284776(CHEMBL36904 | Z-Phe-Tyr(Me)-H)
Affinity DataIC50:  104nMAssay Description:Compound was tested for its inhibitory activity against calpain 2More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50284780(CHEMBL36801 | Z-Phe-Phe-H)
Affinity DataIC50:  104nMAssay Description:Compound was tested for its inhibitory activity against Calpain 2More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25894((2S)-3-methyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-2...)
Affinity DataIC50:  110nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50263561(2-(2-(2-methoxyethoxy)ethoxy)ethyl (S)-1-((S)-4-(c...)
Affinity DataIC50:  120nMAssay Description:Inhibition of pig kidney m-calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189825((2S)-2-((((4-cyanophenyl)amino)thioxomethyl)amino)...)
Affinity DataIC50:  120nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25886((2S)-2-(furan-2-ylformamido)-3-methyl-N-[(2S)-4-me...)
Affinity DataIC50:  135nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25895(N-heterocyclic dipeptide aldehyde, 13 | methyl 5-{...)
Affinity DataIC50:  140nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM23866(MDL28170 | Z-Val-Phe-CHO | benzyl N-[(1S)-2-methyl...)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:Inhibition of m-calpain was assayed in the reaction buffer (50 mM Tris-HCl, 100 mM NaCl, 5 mM β-mercaptoethanol, and 1 mM EDTA, pH 7.5) with 50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25893((2S)-2-[(5-formyl-1-methyl-1H-pyrrol-2-yl)formamid...)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50503845(CHEMBL4531762)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant porcine calpain 2 protease using BODIPY-FL casein as substrate measured at 30 secs time interval for 30 mins by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50263613(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethyl (S)-1...)
Affinity DataIC50:  170nMAssay Description:Inhibition of pig kidney m-calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189834((2S)-2-((((3-cyanophenyl)amino)thioxomethyl)amino)...)
Affinity DataIC50:  170nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189832((2S)-4-methyl-2-((((4-methylphenyl)amino)thioxomet...)
Affinity DataIC50:  170nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358155(CHEMBL1921832)
Affinity DataIC50:  180nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50084650(CHEMBL177914 | {(S)-1-[(S)-1-Formyl-2-(4-hydroxy-p...)
Affinity DataIC50:  184nMAssay Description:Inhibitory activity against Calpain 2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50284779(CHEMBL36146 | Z-Phe-Tyr-H)
Affinity DataIC50:  184nMAssay Description:Compound was tested for its inhibitory activity against calpain 2More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189828(1-((S)-1-((3S)-2-hydroxy-tetrahydrofuran-3-ylamino...)
Affinity DataIC50:  190nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189835((2S)-2-((((4-fluorophenyl)amino)thioxomethyl)amino...)
Affinity DataIC50:  190nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50263558(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)e...)
Affinity DataIC50:  190nMAssay Description:Inhibition of pig kidney m-calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189827((2S)-2-((((4-methoxyphenyl)amino)thioxomethyl)amin...)
Affinity DataIC50:  200nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189822((2S)-2-((benzylamino)thioxomethyl)amino)-4-methyl-...)
Affinity DataIC50:  240nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189830((2S)-4-methyl-2-((((2-methylphenyl)amino)thioxomet...)
Affinity DataIC50:  250nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358148(CHEMBL1921825)
Affinity DataIC50:  280nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358157(CHEMBL1921834)
Affinity DataIC50:  295nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Ovis aries (sheep))
University Of Canterbury

LigandPNGBDBM25888((2S)-3-methyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-2...)
Affinity DataIC50:  315nMpH: 7.5 T: 2°CAssay Description:Calpain inhibition assays were performed in 96-well black plates. The reaction was initiated by the addition of substrate solution. The progress of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189831((2S)-4-methyl-2-((((3-methylphenyl)amino)thioxomet...)
Affinity DataIC50:  340nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM110185(Z-FF-FMK | benzyl N-[1-[(4-fluoro-3-oxo-1-phenylbu...)
Affinity DataIC50:  418nMpH: 7.5 T: 2°CAssay Description:Inhibition of m-calpain was assayed in the reaction buffer (50 mM Tris-HCl, 100 mM NaCl, 5 mM β-mercaptoethanol, and 1 mM EDTA, pH 7.5) with 50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358154(CHEMBL1921831)
Affinity DataIC50:  700nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358150(CHEMBL1921827)
Affinity DataIC50:  850nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358158(CHEMBL1921835)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358156(CHEMBL1921833)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189823((2S,3S)-3-methyl-2-(((phenylamino)thioxomethyl)ami...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50189829((2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50358149(CHEMBL1921826)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of CAPN2 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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