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Compile Data Set for Download or QSAR

Found 5670 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99330
PNG
(US8497281, 108)
Show SMILES CC(C)(O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C24H27N3O2/c1-24(2,29)17-7-8-18-15(12-17)6-10-22-19(18)4-3-11-27(22)23(28)16-5-9-20-21(13-16)26-14-25-20/h5,7-9,12-14,19,22,29H,3-4,6,10-11H2,1-2H3,(H,25,26)/t19?,22-/m0/s1
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n/an/a 1.12E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99331
PNG
(US8497281, 109)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1cc(ccc21)C#N)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C22H20N4O/c23-12-14-3-6-17-15(10-14)5-8-21-18(17)2-1-9-26(21)22(27)16-4-7-19-20(11-16)25-13-24-19/h3-4,6-7,10-11,13,18,21H,1-2,5,8-9H2,(H,24,25)/t18?,21-/m0/s1
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n/an/a 418n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99332
PNG
(US8497281, 110 | US9120769, 43)
Show SMILES Nc1nc2ccc(cc2s1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H21N3OS/c22-21-23-17-9-7-14(12-19(17)26-21)20(25)24-11-3-6-16-15-5-2-1-4-13(15)8-10-18(16)24/h1-2,4-5,7,9,12,16,18H,3,6,8,10-11H2,(H2,22,23)/t16?,18-/m0/s1
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n/an/a 1.63E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99333
PNG
(US8497281, 44 | US9120769, 44)
Show SMILES Cc1ccc(cc1O)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H23NO2/c1-14-8-9-16(13-20(14)23)21(24)22-12-4-7-18-17-6-3-2-5-15(17)10-11-19(18)22/h2-3,5-6,8-9,13,18-19,23H,4,7,10-12H2,1H3/t18?,19-/m0/s1
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n/an/a 2.15E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99334
PNG
(US8497281, 112 | US9120769, 45)
Show SMILES COc1ccc(cc1N)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H24N2O2/c1-25-20-11-9-15(13-18(20)22)21(24)23-12-4-7-17-16-6-3-2-5-14(16)8-10-19(17)23/h2-3,5-6,9,11,13,17,19H,4,7-8,10,12,22H2,1H3/t17?,19-/m0/s1
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n/an/a 1.07E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99335
PNG
(US8497281, 46 | US9120769, 46)
Show SMILES Cc1cc2cc(ccc2[nH]1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C23H24N2O/c1-15-13-18-14-17(8-10-21(18)24-15)23(26)25-12-4-7-20-19-6-3-2-5-16(19)9-11-22(20)25/h2-3,5-6,8,10,13-14,20,22,24H,4,7,9,11-12H2,1H3/t20?,22-/m0/s1
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n/an/a 3.62E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99336
PNG
(US8497281, 47 | US9120769, 47)
Show SMILES Cn1c2ccc(cc2[nH]c1=O)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C22H23N3O2/c1-24-20-11-9-15(13-18(20)23-22(24)27)21(26)25-12-4-7-17-16-6-3-2-5-14(16)8-10-19(17)25/h2-3,5-6,9,11,13,17,19H,4,7-8,10,12H2,1H3,(H,23,27)/t17?,19-/m0/s1
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n/an/a 2.16E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99337
PNG
(US8497281, 115 | US9120769, 48)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C22H22N2O/c25-22(17-8-7-16-11-12-23-20(16)14-17)24-13-3-6-19-18-5-2-1-4-15(18)9-10-21(19)24/h1-2,4-5,7-8,11-12,14,19,21,23H,3,6,9-10,13H2/t19?,21-/m0/s1
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n/an/a 514n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99338
PNG
(US8497281, 116 | US9120769, 49)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C22H22N2O2/c25-21-13-16-12-15(7-9-19(16)23-21)22(26)24-11-3-6-18-17-5-2-1-4-14(17)8-10-20(18)24/h1-2,4-5,7,9,12,18,20H,3,6,8,10-11,13H2,(H,23,25)/t18?,20-/m0/s1
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n/an/a 1.47E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99339
PNG
(US8497281, 50 | US9120769, 50)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2CC(=O)Nc2c1
Show InChI InChI=1S/C22H22N2O2/c25-21-13-15-7-8-16(12-19(15)23-21)22(26)24-11-3-6-18-17-5-2-1-4-14(17)9-10-20(18)24/h1-2,4-5,7-8,12,18,20H,3,6,9-11,13H2,(H,23,25)/t18?,20-/m0/s1
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n/an/a 4.27E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99340
PNG
(US8497281, 51 | US9120769, 51)
Show SMILES Cn1cnc2cc(ccc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C22H23N3O/c1-24-14-23-19-13-16(9-11-21(19)24)22(26)25-12-4-7-18-17-6-3-2-5-15(17)8-10-20(18)25/h2-3,5-6,9,11,13-14,18,20H,4,7-8,10,12H2,1H3/t18?,20-/m0/s1
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n/an/a 2.87E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99341
PNG
(US8497281, 119 | US9120769, 52)
Show SMILES Cn1nnc2cc(ccc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H22N4O/c1-24-20-11-9-15(13-18(20)22-23-24)21(26)25-12-4-7-17-16-6-3-2-5-14(16)8-10-19(17)25/h2-3,5-6,9,11,13,17,19H,4,7-8,10,12H2,1H3/t17?,19-/m0/s1
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n/an/a 1.60E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99342
PNG
(US8497281, 120 | US9120769, 53)
Show SMILES COc1cccc2C3CCCN([C@H]3CCc12)C(=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C24H26N2O2/c1-25-15-20(18-7-3-4-10-21(18)25)24(27)26-14-6-9-17-16-8-5-11-23(28-2)19(16)12-13-22(17)26/h3-5,7-8,10-11,15,17,22H,6,9,12-14H2,1-2H3/t17?,22-/m0/s1
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n/an/a 979n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99343
PNG
(US8497281, 121 | US9120769, 54)
Show SMILES Oc1ccc(cc1F)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H20FNO2/c21-17-12-14(8-10-19(17)23)20(24)22-11-3-6-16-15-5-2-1-4-13(15)7-9-18(16)22/h1-2,4-5,8,10,12,16,18,23H,3,6-7,9,11H2/t16?,18-/m0/s1
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n/an/a 471n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99344
PNG
(US8497281, 55 | US9120769, 55)
Show SMILES Cc1nc2ccc(cc2[nH]1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C22H23N3O/c1-14-23-19-10-8-16(13-20(19)24-14)22(26)25-12-4-7-18-17-6-3-2-5-15(17)9-11-21(18)25/h2-3,5-6,8,10,13,18,21H,4,7,9,11-12H2,1H3,(H,23,24)/t18?,21-/m0/s1
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n/an/a 4.68E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99345
PNG
(US8497281, 123 | US9120769, 56)
Show SMILES Nc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21ClN2O/c21-17-12-14(7-9-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 356n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99346
PNG
(US8497281, 124 | US9120769, 57)
Show SMILES Nc1nc2ccc(cc2[nH]1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H22N4O/c22-21-23-17-9-7-14(12-18(17)24-21)20(26)25-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)25/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11H2,(H3,22,23,24)/t16?,19-/m0/s1
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n/an/a 969n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99347
PNG
(US8497281, 125 | US9120769, 58)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2ncsc2c1
Show InChI InChI=1S/C21H20N2OS/c24-21(15-7-9-18-20(12-15)25-13-22-18)23-11-3-6-17-16-5-2-1-4-14(16)8-10-19(17)23/h1-2,4-5,7,9,12-13,17,19H,3,6,8,10-11H2/t17?,19-/m0/s1
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n/an/a 1.11E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99348
PNG
(US8497281, 59 | US9120769, 59)
Show SMILES Oc1cc(ccc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H20ClNO2/c21-17-9-7-14(12-19(17)23)20(24)22-11-3-6-16-15-5-2-1-4-13(15)8-10-18(16)22/h1-2,4-5,7,9,12,16,18,23H,3,6,8,10-11H2/t16?,18-/m0/s1
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n/an/a 2.10E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99319
PNG
(US8497281, 127 | US8497281, 30 | US9120769, 30)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]cnc2n1
Show InChI InChI=1S/C20H20N4O/c25-20(17-9-8-16-19(23-17)22-12-21-16)24-11-3-6-15-14-5-2-1-4-13(14)7-10-18(15)24/h1-2,4-5,8-9,12,15,18H,3,6-7,10-11H2,(H,21,22,23)/t15?,18-/m0/s1
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n/an/a 1.05E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99350
PNG
(US8497281, 128 | US9120769, 61)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C21H19N3O2/c25-20(14-7-9-17-18(12-14)23-21(26)22-17)24-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)24/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11H2/t16?,19-/m0/s1
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n/an/a 821n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99351
PNG
(US8497281, 129 | US9120769, 62)
Show SMILES Cn1cnc2ccc(cc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C22H23N3O/c1-24-14-23-19-10-8-16(13-21(19)24)22(26)25-12-4-7-18-17-6-3-2-5-15(17)9-11-20(18)25/h2-3,5-6,8,10,13-14,18,20H,4,7,9,11-12H2,1H3/t18?,20-/m0/s1
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n/an/a 940n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99352
PNG
(US8497281, 130 | US9120769, 63)
Show SMILES Nc1cc(ccc1F)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21FN2O/c21-17-9-7-14(12-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 1.34E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99353
PNG
(US8497281, 64 | US9120769, 64)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccn2ccnc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(16-9-12-23-13-10-22-20(23)14-16)24-11-3-6-18-17-5-2-1-4-15(17)7-8-19(18)24/h1-2,4-5,9-10,12-14,18-19H,3,6-8,11H2/t18?,19-/m0/s1
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n/an/a 2.87E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99354
PNG
(US8497281, 132 | US9120769, 65)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-19-16(12-15)13-22-23-19)24-11-3-6-18-17-5-2-1-4-14(17)8-10-20(18)24/h1-2,4-5,7,9,12-13,18,20H,3,6,8,10-11H2,(H,22,23)/t18?,20-/m0/s1
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n/an/a 212n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99355
PNG
(US8497281, 133 | US9120769, 66)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C24H26N2O2/c1-24(2)19-14-16(9-11-20(19)25-23(24)28)22(27)26-13-5-8-18-17-7-4-3-6-15(17)10-12-21(18)26/h3-4,6-7,9,11,14,18,21H,5,8,10,12-13H2,1-2H3,(H,25,28)/t18?,21-/m0/s1
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n/an/a 631n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99356
PNG
(US8497281, 134 | US9120769, 67)
Show SMILES Nc1ccc(cc1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H22N2O/c21-16-10-7-15(8-11-16)20(23)22-13-3-6-18-17-5-2-1-4-14(17)9-12-19(18)22/h1-2,4-5,7-8,10-11,18-19H,3,6,9,12-13,21H2/t18?,19-/m0/s1
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n/an/a 722n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99290
PNG
(US8497281, 135 | US8497281, 68 | US9120769, 68)
Show SMILES Oc1ccc(cc1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21NO2/c22-16-10-7-15(8-11-16)20(23)21-13-3-6-18-17-5-2-1-4-14(17)9-12-19(18)21/h1-2,4-5,7-8,10-11,18-19,22H,3,6,9,12-13H2/t18?,19-/m0/s1
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n/an/a 435n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99358
PNG
(US8497281, 136 | US9120769, 69)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H22N2O/c25-22(17-7-9-20-16(14-17)11-12-23-20)24-13-3-6-19-18-5-2-1-4-15(18)8-10-21(19)24/h1-2,4-5,7,9,11-12,14,19,21,23H,3,6,8,10,13H2/t19?,21-/m0/s1
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n/an/a 371n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99359
PNG
(US8497281, 137 | US9120769, 70)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1c[nH]c2ccccc12
Show InChI InChI=1S/C22H22N2O/c25-22(19-14-23-20-10-4-3-8-17(19)20)24-13-5-9-18-16-7-2-1-6-15(16)11-12-21(18)24/h1-4,6-8,10,14,18,21,23H,5,9,11-13H2/t18?,21-/m0/s1
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n/an/a 350n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99360
PNG
(US8497281, 138 | US9120769, 71)
Show SMILES Oc1c(Cl)cc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H19Cl2NO2/c21-16-10-13(11-17(22)19(16)24)20(25)23-9-3-6-15-14-5-2-1-4-12(14)7-8-18(15)23/h1-2,4-5,10-11,15,18,24H,3,6-9H2/t15?,18-/m0/s1
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n/an/a 915n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99361
PNG
(US8497281, 139)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2nn[nH]c2c1
Show InChI InChI=1S/C20H20N4O/c25-20(14-7-9-17-18(12-14)22-23-21-17)24-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)24/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11H2,(H,21,22,23)/t16?,19-/m0/s1
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n/an/a 656n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99362
PNG
(US8497281, 140 | US9120769, 73)
Show SMILES Cn1cc(C(=O)N2CCCC3[C@@H]2CCc2ccccc32)c2ccccc12
Show InChI InChI=1S/C23H24N2O/c1-24-15-20(19-9-4-5-11-21(19)24)23(26)25-14-6-10-18-17-8-3-2-7-16(17)12-13-22(18)25/h2-5,7-9,11,15,18,22H,6,10,12-14H2,1H3/t18?,22-/m0/s1
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n/an/a 447n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99363
PNG
(US8497281, 74 | US9120769, 74)
Show SMILES COc1ccc(cc1O)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H23NO3/c1-25-20-11-9-15(13-19(20)23)21(24)22-12-4-7-17-16-6-3-2-5-14(16)8-10-18(17)22/h2-3,5-6,9,11,13,17-18,23H,4,7-8,10,12H2,1H3/t17?,18-/m0/s1
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n/an/a 1.96E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99364
PNG
(US8497281, 142 | US9120769, 75)
Show SMILES Oc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H20ClNO2/c21-17-12-14(8-10-19(17)23)20(24)22-11-3-6-16-15-5-2-1-4-13(15)7-9-18(16)22/h1-2,4-5,8,10,12,16,18,23H,3,6-7,9,11H2/t16?,18-/m0/s1
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n/an/a 324n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99365
PNG
(US8497281, 143 | US9120769, 76)
Show SMILES Nc1cc(ccc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21ClN2O/c21-17-9-7-14(12-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 933n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99366
PNG
(US8497281, 144 | US9120769, 77)
Show SMILES Cc1ccc(cc1N)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H24N2O/c1-14-8-9-16(13-19(14)22)21(24)23-12-4-7-18-17-6-3-2-5-15(17)10-11-20(18)23/h2-3,5-6,8-9,13,18,20H,4,7,10-12,22H2,1H3/t18?,20-/m0/s1
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n/an/a 685n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99367
PNG
(US8497281, 145 | US9120769, 78)
Show SMILES COc1cc(ccc1N)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H24N2O2/c1-25-20-13-15(8-10-18(20)22)21(24)23-12-4-7-17-16-6-3-2-5-14(16)9-11-19(17)23/h2-3,5-6,8,10,13,17,19H,4,7,9,11-12,22H2,1H3/t17?,19-/m0/s1
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n/an/a 257n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99368
PNG
(US8497281, 146 | US9120769, 79)
Show SMILES Nc1ccc(cc1F)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21FN2O/c21-17-12-14(7-9-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 650n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99290
PNG
(US8497281, 135 | US8497281, 68 | US9120769, 68)
Show SMILES Oc1ccc(cc1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21NO2/c22-16-10-7-15(8-11-16)20(23)21-13-3-6-18-17-5-2-1-4-14(17)9-12-19(18)21/h1-2,4-5,7-8,10-11,18-19,22H,3,6,9,12-13H2/t18?,19-/m0/s1
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n/an/a 106n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99291
PNG
(US8497281, 69)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-18-19(12-15)23-13-22-18)24-11-3-6-17-16-5-2-1-4-14(16)8-10-20(17)24/h1-2,4-5,7,9,12-13,17,20H,3,6,8,10-11H2,(H,22,23)/t17?,20-/m0/s1
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n/an/a 65n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99292
PNG
(US8497281, 70)
Show SMILES O=C(N1CCC[C@@H]2[C@H]1CCc1ccccc21)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-18-19(12-15)23-13-22-18)24-11-3-6-17-16-5-2-1-4-14(16)8-10-20(17)24/h1-2,4-5,7,9,12-13,17,20H,3,6,8,10-11H2,(H,22,23)/t17-,20+/m0/s1
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n/an/a 1.38E+3n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99293
PNG
(US8497281, 71)
Show SMILES O=C(N1CCCC2[C@H]1CCc1ccccc21)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-18-19(12-15)23-13-22-18)24-11-3-6-17-16-5-2-1-4-14(16)8-10-20(17)24/h1-2,4-5,7,9,12-13,17,20H,3,6,8,10-11H2,(H,22,23)/t17?,20-/m1/s1
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n/an/a 573n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99294
PNG
(US8497281, 72 | US9120769, 5)
Show SMILES NC(=O)c1ccc(cc1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H22N2O2/c22-20(24)15-7-9-16(10-8-15)21(25)23-13-3-6-18-17-5-2-1-4-14(17)11-12-19(18)23/h1-2,4-5,7-10,18-19H,3,6,11-13H2,(H2,22,24)/t18?,19-/m0/s1
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n/an/a 861n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99295
PNG
(US8497281, 73)
Show SMILES COc1cccc2C3CCCN([C@H]3CCc12)C(=O)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-21-6-2-4-15-16-5-3-11-25(20(16)10-8-17(15)21)22(26)14-7-9-18-19(12-14)24-13-23-18/h2,4,6-7,9,12-13,16,20H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,20-/m0/s1
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n/an/a 296n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99296
PNG
(US8497281, 74)
Show SMILES Oc1cccc2C3CCCN([C@H]3CCc12)C(=O)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C21H21N3O2/c25-20-5-1-3-14-15-4-2-10-24(19(15)9-7-16(14)20)21(26)13-6-8-17-18(11-13)23-12-22-17/h1,3,5-6,8,11-12,15,19,25H,2,4,7,9-10H2,(H,22,23)/t15?,19-/m0/s1
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n/an/a 410n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99297
PNG
(US8497281, 75)
Show SMILES COc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4nc[nH]c4c3)c12
Show InChI InChI=1S/C22H23N3O2/c1-27-20-6-2-4-14-8-10-19-16(21(14)20)5-3-11-25(19)22(26)15-7-9-17-18(12-15)24-13-23-17/h2,4,6-7,9,12-13,16,19H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,19-/m0/s1
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n/an/a 342n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99298
PNG
(US8497281, 76)
Show SMILES COc1cccc2CC[C@@H]3C(CCCN3C(=O)c3ccc4nc[nH]c4c3)c12
Show InChI InChI=1S/C22H23N3O2/c1-27-20-6-2-4-14-8-10-19-16(21(14)20)5-3-11-25(19)22(26)15-7-9-17-18(12-15)24-13-23-17/h2,4,6-7,9,12-13,16,19H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,19-/m1/s1
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n/an/a 481n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99299
PNG
(US8497281, 77)
Show SMILES C[C@]12CCCN([C@H]1CCc1ccccc21)C(=O)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C22H23N3O/c1-22-11-4-12-25(20(22)10-8-15-5-2-3-6-17(15)22)21(26)16-7-9-18-19(13-16)24-14-23-18/h2-3,5-7,9,13-14,20H,4,8,10-12H2,1H3,(H,23,24)/t20-,22+/m0/s1
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n/an/a 321n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99300
PNG
(US8497281, 78)
Show SMILES C[C@]12CCCN([C@@H]1CCc1ccccc21)C(=O)c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C22H23N3O/c1-22-11-4-12-25(20(22)10-8-15-5-2-3-6-17(15)22)21(26)16-7-9-18-19(13-16)24-14-23-18/h2-3,5-7,9,13-14,20H,4,8,10-12H2,1H3,(H,23,24)/t20-,22-/m1/s1
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n/an/a 94n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...


US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair
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