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Compile Data Set for Download or QSAR

Found 1586 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PLK1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27444
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-me...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccc(cc4)S(C)(=O)=O)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26)
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n/an/a 126n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27445
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-me...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccc(cc4)S(C)(=O)=O)c(s3)C#N)c2cc1OC
Show InChI InChI=1S/C22H19N3O5S2/c1-28-18-8-16-17(9-19(18)29-2)25(13-24-16)22-10-20(21(11-23)31-22)30-12-14-4-6-15(7-5-14)32(3,26)27/h4-10,13H,12H2,1-3H3
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n/an/a 631n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27446
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxola...)
Show SMILES COc1cc2ncn(-c3cc(OCC4CCCO4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C19H21N3O5S/c1-24-14-6-12-13(7-15(14)25-2)22(10-21-12)17-8-16(18(28-17)19(20)23)27-9-11-4-3-5-26-11/h6-8,10-11H,3-5,9H2,1-2H3,(H2,20,23)
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n/an/a 251n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27447
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxola...)
Show SMILES COc1cc2ncn(-c3cc(OCC4CCCO4)c(s3)C#N)c2cc1OC
Show InChI InChI=1S/C19H19N3O4S/c1-23-15-6-13-14(7-16(15)24-2)22(11-21-13)19-8-17(18(9-20)27-19)26-10-12-4-3-5-25-12/h6-8,11-12H,3-5,10H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27452
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-me...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(s3)C#N)c2cc1OC
Show InChI InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3
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n/an/a 794n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27443
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)met...)
Show SMILES Cc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1
Show InChI InChI=1S/C20H17N3O2S/c1-13-6-8-14(9-7-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 126n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28156
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-(benzyloxy)thiophene...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1)-n1cnc2ccccc12
Show InChI InChI=1S/C19H15N3O2S/c20-19(23)18-16(24-11-13-6-2-1-3-7-13)10-17(25-18)22-12-21-14-8-4-5-9-15(14)22/h1-10,12H,11H2,(H2,20,23)
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n/an/a 61n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28157
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-methylphenyl)met...)
Show SMILES Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccccc12
Show InChI InChI=1S/C20H17N3O2S/c1-13-6-2-3-7-14(13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-8-4-5-9-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28158
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(3-methylphenyl)met...)
Show SMILES Cc1cccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)c1
Show InChI InChI=1S/C20H17N3O2S/c1-13-5-4-6-14(9-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-7-2-3-8-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27443
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)met...)
Show SMILES Cc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1
Show InChI InChI=1S/C20H17N3O2S/c1-13-6-8-14(9-7-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 70n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28159
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-methoxyphenyl)me...)
Show SMILES COc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccccc12
Show InChI InChI=1S/C20H17N3O3S/c1-25-16-9-5-2-6-13(16)11-26-17-10-18(27-19(17)20(21)24)23-12-22-14-7-3-4-8-15(14)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28160
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(3-methoxyphenyl)me...)
Show SMILES COc1cccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)c1
Show InChI InChI=1S/C20H17N3O3S/c1-25-14-6-4-5-13(9-14)11-26-17-10-18(27-19(17)20(21)24)23-12-22-15-7-2-3-8-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 28n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28161
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methoxyphenyl)me...)
Show SMILES COc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1
Show InChI InChI=1S/C20H17N3O3S/c1-25-14-8-6-13(7-9-14)11-26-17-10-18(27-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 35n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28162
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Cl)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28163
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(3-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1cccc(Cl)c1)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-5-3-4-12(8-13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-6-1-2-7-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 22n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28164
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1ccc(Cl)cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-7-5-12(6-8-13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-3-1-2-4-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 100n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28165
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-n1cnc2ccccc12
Show InChI InChI=1S/C20H14F3N3O2S/c21-20(22,23)13-6-2-1-5-12(13)10-28-16-9-17(29-18(16)19(24)27)26-11-25-14-7-3-4-8-15(14)26/h1-9,11H,10H2,(H2,24,27)
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n/an/a 15n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28166
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-bromophenyl)meth...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Br)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14BrN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 11n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28167
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-fluorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1F)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14FN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24)
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PubMed
n/an/a 14n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28168
PNG
(5-(5-chloro-1H-1,3-benzodiazol-1-yl)-3-[(2-methylp...)
Show SMILES Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2cc(Cl)ccc12
Show InChI InChI=1S/C20H16ClN3O2S/c1-12-4-2-3-5-13(12)10-26-17-9-18(27-19(17)20(22)25)24-11-23-15-8-14(21)6-7-16(15)24/h2-9,11H,10H2,1H3,(H2,22,25)
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PubMed
n/an/a 21n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28169
PNG
(5-(6-chloro-1H-1,3-benzodiazol-1-yl)-3-[(2-methylp...)
Show SMILES Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccc(Cl)cc12
Show InChI InChI=1S/C20H16ClN3O2S/c1-12-4-2-3-5-13(12)10-26-17-9-18(27-19(17)20(22)25)24-11-23-15-7-6-14(21)8-16(15)24/h2-9,11H,10H2,1H3,(H2,22,25)
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PubMed
n/an/a 4n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28170
PNG
(3-[(2-bromophenyl)methoxy]-5-[5-(trifluoromethyl)-...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Br)-n1cnc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C20H13BrF3N3O2S/c21-13-4-2-1-3-11(13)9-29-16-8-17(30-18(16)19(25)28)27-10-26-14-7-12(20(22,23)24)5-6-15(14)27/h1-8,10H,9H2,(H2,25,28)
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n/an/a 300n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28171
PNG
(3-[(2-bromophenyl)methoxy]-5-[6-(trifluoromethyl)-...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Br)-n1cnc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C20H13BrF3N3O2S/c21-13-4-2-1-3-11(13)9-29-16-8-17(30-18(16)19(25)28)27-10-26-14-6-5-12(7-15(14)27)20(22,23)24/h1-8,10H,9H2,(H2,25,28)
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PubMed
n/an/a 9n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28172
PNG
(5-(5-methanesulfonyl-1H-1,3-benzodiazol-1-yl)-3-{[...)
Show SMILES CS(=O)(=O)c1ccc2n(cnc2c1)-c1cc(OCc2ccccc2C(F)(F)F)c(s1)C(N)=O
Show InChI InChI=1S/C21H16F3N3O4S2/c1-33(29,30)13-6-7-16-15(8-13)26-11-27(16)18-9-17(19(32-18)20(25)28)31-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28)
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n/an/a 250n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28173
PNG
(5-(6-methanesulfonyl-1H-1,3-benzodiazol-1-yl)-3-{[...)
Show SMILES CS(=O)(=O)c1ccc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2c1
Show InChI InChI=1S/C21H16F3N3O4S2/c1-33(29,30)13-6-7-15-16(8-13)27(11-26-15)18-9-17(19(32-18)20(25)28)31-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28174
PNG
(5-(5-methoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifl...)
Show SMILES COc1ccc2n(cnc2c1)-c1cc(OCc2ccccc2C(F)(F)F)c(s1)C(N)=O
Show InChI InChI=1S/C21H16F3N3O3S/c1-29-13-6-7-16-15(8-13)26-11-27(16)18-9-17(19(31-18)20(25)28)30-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28)
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n/an/a 8n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28175
PNG
(5-(6-methoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifl...)
Show SMILES COc1ccc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2c1
Show InChI InChI=1S/C21H16F3N3O3S/c1-29-13-6-7-15-16(8-13)27(11-26-15)18-9-17(19(31-18)20(25)28)30-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28)
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25120
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(t...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29)
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28176
PNG
(3-(benzyloxy)-5-(5,6-dimethoxy-1H-1,3-benzodiazol-...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H19N3O4S/c1-26-16-8-14-15(9-17(16)27-2)24(12-23-14)19-10-18(20(29-19)21(22)25)28-11-13-6-4-3-5-7-13/h3-10,12H,11H2,1-2H3,(H2,22,25)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28177
PNG
(3-[(2-bromophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4Br)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H18BrN3O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-5-3-4-6-13(12)22/h3-9,11H,10H2,1-2H3,(H2,23,26)
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28178
PNG
(3-[(2-chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4Cl)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H18ClN3O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-5-3-4-6-13(12)22/h3-9,11H,10H2,1-2H3,(H2,23,26)
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28179
PNG
(3-[(2-cyanophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C#N)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H18N4O4S/c1-28-17-7-15-16(8-18(17)29-2)26(12-25-15)20-9-19(21(31-20)22(24)27)30-11-14-6-4-3-5-13(14)10-23/h3-9,12H,11H2,1-2H3,(H2,24,27)
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PubMed
n/an/a 6n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28178
PNG
(3-[(2-chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4Cl)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H18ClN3O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-5-3-4-6-13(12)22/h3-9,11H,10H2,1-2H3,(H2,23,26)
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28206
PNG
(3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(5,6-dimethoxy...)
Show SMILES COc1cc2ncn(-c3cc(O[C@H](C)c4ccccc4Cl)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H20ClN3O4S/c1-12(13-6-4-5-7-14(13)23)30-19-10-20(31-21(19)22(24)27)26-11-25-15-8-17(28-2)18(29-3)9-16(15)26/h4-12H,1-3H3,(H2,24,27)/t12-/m1/s1
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n/an/a 0.800n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28207
PNG
(3-[(1S)-1-(2-chlorophenyl)ethoxy]-5-(5,6-dimethoxy...)
Show SMILES COc1cc2ncn(-c3cc(O[C@@H](C)c4ccccc4Cl)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H20ClN3O4S/c1-12(13-6-4-5-7-14(13)23)30-19-10-20(31-21(19)22(24)27)26-11-25-15-8-17(28-2)18(29-3)9-16(15)26/h4-12H,1-3H3,(H2,24,27)/t12-/m0/s1
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n/an/a 30n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28208
PNG
(3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(6-methoxy-1H-...)
Show SMILES COc1ccc2ncn(-c3cc(O[C@H](C)c4ccccc4Cl)c(s3)C(N)=O)c2c1
Show InChI InChI=1S/C21H18ClN3O3S/c1-12(14-5-3-4-6-15(14)22)28-18-10-19(29-20(18)21(23)26)25-11-24-16-8-7-13(27-2)9-17(16)25/h3-12H,1-2H3,(H2,23,26)/t12-/m1/s1
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n/an/a 1n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28209
PNG
(5-(6-methoxy-1H-1,3-benzodiazol-1-yl)-3-[(1R)-1-[2...)
Show SMILES COc1ccc2ncn(-c3cc(O[C@H](C)c4ccccc4C(F)(F)F)c(s3)C(N)=O)c2c1
Show InChI InChI=1S/C22H18F3N3O3S/c1-12(14-5-3-4-6-15(14)22(23,24)25)31-18-10-19(32-20(18)21(26)29)28-11-27-16-8-7-13(30-2)9-17(16)28/h3-12H,1-2H3,(H2,26,29)/t12-/m1/s1
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n/an/a 3n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28210
PNG
(3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[(2S)-2,3-d...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC[C@@H](O)CO)cc12)c1ccccc1Cl
Show InChI InChI=1S/C23H22ClN3O5S/c1-13(16-4-2-3-5-17(16)24)32-20-9-21(33-22(20)23(25)30)27-12-26-18-7-6-15(8-19(18)27)31-11-14(29)10-28/h2-9,12-14,28-29H,10-11H2,1H3,(H2,25,30)/t13-,14+/m1/s1
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n/an/a 1n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28211
PNG
(3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[3-(dimethy...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OCCCN(C)C)cc12)c1ccccc1Cl
Show InChI InChI=1S/C25H27ClN4O3S/c1-16(18-7-4-5-8-19(18)26)33-22-14-23(34-24(22)25(27)31)30-15-28-20-10-9-17(13-21(20)30)32-12-6-11-29(2)3/h4-5,7-10,13-16H,6,11-12H2,1-3H3,(H2,27,31)/t16-/m1/s1
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n/an/a 4n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28212
PNG
(3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[(2S)-2-hyd...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC[C@@H](O)CN3CCCC3)cc12)c1ccccc1Cl
Show InChI InChI=1S/C27H29ClN4O4S/c1-17(20-6-2-3-7-21(20)28)36-24-13-25(37-26(24)27(29)34)32-16-30-22-9-8-19(12-23(22)32)35-15-18(33)14-31-10-4-5-11-31/h2-3,6-9,12-13,16-18,33H,4-5,10-11,14-15H2,1H3,(H2,29,34)/t17-,18+/m1/s1
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n/an/a 3n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28213
PNG
(5-{6-[(1-methylpiperidin-4-yl)methoxy]-1H-1,3-benz...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OCC3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C28H29F3N4O3S/c1-17(20-5-3-4-6-21(20)28(29,30)31)38-24-14-25(39-26(24)27(32)36)35-16-33-22-8-7-19(13-23(22)35)37-15-18-9-11-34(2)12-10-18/h3-8,13-14,16-18H,9-12,15H2,1-2H3,(H2,32,36)/t17-/m1/s1
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n/an/a 7n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28214
PNG
(3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[(1-methylp...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OCC3CCN(C)CC3)cc12)c1ccccc1Cl
Show InChI InChI=1S/C27H29ClN4O3S/c1-17(20-5-3-4-6-21(20)28)35-24-14-25(36-26(24)27(29)33)32-16-30-22-8-7-19(13-23(22)32)34-15-18-9-11-31(2)12-10-18/h3-8,13-14,16-18H,9-12,15H2,1-2H3,(H2,29,33)/t17-/m1/s1
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n/an/a 6n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28215
PNG
(5-[6-(piperidin-4-yloxy)-1H-1,3-benzodiazol-1-yl]-...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC3CCNCC3)cc12)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H25F3N4O3S/c1-15(18-4-2-3-5-19(18)26(27,28)29)35-22-13-23(37-24(22)25(30)34)33-14-32-20-7-6-17(12-21(20)33)36-16-8-10-31-11-9-16/h2-7,12-16,31H,8-11H2,1H3,(H2,30,34)/t15-/m1/s1
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n/an/a 3n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28216
PNG
(5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-1,3-benzodia...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H27F3N4O3S/c1-16(19-5-3-4-6-20(19)27(28,29)30)36-23-14-24(38-25(23)26(31)35)34-15-32-21-8-7-18(13-22(21)34)37-17-9-11-33(2)12-10-17/h3-8,13-17H,9-12H2,1-2H3,(H2,31,35)/t16-/m1/s1
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28217
PNG
(3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[(1-methylp...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC3CCN(C)CC3)cc12)c1ccccc1Cl
Show InChI InChI=1S/C26H27ClN4O3S/c1-16(19-5-3-4-6-20(19)27)33-23-14-24(35-25(23)26(28)32)31-15-29-21-8-7-18(13-22(21)31)34-17-9-11-30(2)12-10-17/h3-8,13-17H,9-12H2,1-2H3,(H2,28,32)/t16-/m1/s1
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28218
PNG
(3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(6-{[(4S)-1-me...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(O[C@H]3CCCN(C)CC3)cc12)c1ccccc1Cl
Show InChI InChI=1S/C27H29ClN4O3S/c1-17(20-7-3-4-8-21(20)28)34-24-15-25(36-26(24)27(29)33)32-16-30-22-10-9-19(14-23(22)32)35-18-6-5-12-31(2)13-11-18/h3-4,7-10,14-18H,5-6,11-13H2,1-2H3,(H2,29,33)/t17-,18+/m1/s1
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n/an/a 3n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28219
PNG
(3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(6-{[(4R)-1-me...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(O[C@@H]3CCCN(C)CC3)cc12)c1ccccc1Cl
Show InChI InChI=1S/C27H29ClN4O3S/c1-17(20-7-3-4-8-21(20)28)34-24-15-25(36-26(24)27(29)33)32-16-30-22-10-9-19(14-23(22)32)35-18-6-5-12-31(2)13-11-18/h3-4,7-10,14-18H,5-6,11-13H2,1-2H3,(H2,29,33)/t17-,18-/m1/s1
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n/an/a 4n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1694-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.094
BindingDB Entry DOI: 10.7270/Q2319T6X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24925
PNG
(3-methyl-1-phenyl-N-[(1S)-1-phenylethyl]-1H-pyrazo...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H20N4/c1-15(17-9-5-3-6-10-17)23-21-13-20-19(14-22-21)16(2)24-25(20)18-11-7-4-8-12-18/h3-15H,1-2H3,(H,22,23)/t15-/m0/s1
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n/an/a 1.30E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5186-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.091
BindingDB Entry DOI: 10.7270/Q22Z13T8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24926
PNG
(1-(3-chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H19ClN4/c1-14(16-7-4-3-5-8-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-6-9-17(22)11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1
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n/an/a 121n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5186-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.091
BindingDB Entry DOI: 10.7270/Q22Z13T8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24927
PNG
(2-amino-isoxazolopyridine, 3 | 3-phenyl-N-[(1S)-1-...)
Show SMILES C[C@H](Nc1cc2c(noc2cn1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H17N3O/c1-14(15-8-4-2-5-9-15)22-19-12-17-18(13-21-19)24-23-20(17)16-10-6-3-7-11-16/h2-14H,1H3,(H,21,22)/t14-/m0/s1
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n/an/a 1.62E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5186-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.091
BindingDB Entry DOI: 10.7270/Q22Z13T8
More data for this
Ligand-Target Pair
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