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Compile Data Set for Download or QSAR

Found 1325 hits Enz. Inhib. hit(s) with Target = 'Tyrosinase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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290 -37.6n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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640 -35.6n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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950 -35.8n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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1.05E+3 -35.5n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50382706
PNG
(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Show SMILES [S-]C(=S)NCc1ccccc1
Show InChI InChI=1S/C8H9NS2/c10-8(11)9-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10,11)/p-1
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5.70E+3 -31.1n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50382706
PNG
(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Show SMILES [S-]C(=S)NCc1ccccc1
Show InChI InChI=1S/C8H9NS2/c10-8(11)9-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10,11)/p-1
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5.90E+3 -31.0n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM86064
PNG
(Iso-pentyl xanthate, III)
Show SMILES CC(C)CCOC(=S)S[Na]
Show InChI InChI=1S/C6H12OS2.Na/c1-5(2)3-4-7-6(8)9;/h5H,3-4H2,1-2H3,(H,8,9);/q;+1/p-1
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6.10E+3 -29.3n/an/an/an/an/a6.820



University of Tehran



Assay Description
Kinetic assay of catecholase and cresolase activities was carried out through depletion of MeBACat and MePAPh for 1 or 2 min with enzyme concentratio...


J Enzyme Inhib Med Chem 22: 239-46 (2007)


Article DOI: 10.1080/14756360601114536
BindingDB Entry DOI: 10.7270/Q2XS5SZW
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM86063
PNG
(Iso-butyl xanthate, II)
Show SMILES CC(C)COC(=S)S[Na]
Show InChI InChI=1S/C5H10OS2.Na/c1-4(2)3-6-5(7)8;/h4H,3H2,1-2H3,(H,7,8);/q;+1/p-1
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7.20E+3 -28.9n/an/an/an/an/a6.820



University of Tehran



Assay Description
Kinetic assay of catecholase and cresolase activities was carried out through depletion of MeBACat and MePAPh for 1 or 2 min with enzyme concentratio...


J Enzyme Inhib Med Chem 22: 239-46 (2007)


Article DOI: 10.1080/14756360601114536
BindingDB Entry DOI: 10.7270/Q2XS5SZW
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50382706
PNG
(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Show SMILES [S-]C(=S)NCc1ccccc1
Show InChI InChI=1S/C8H9NS2/c10-8(11)9-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10,11)/p-1
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9.40E+3 -28.9n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM86062
PNG
(Iso-propyl xanthate, I)
Show SMILES CC(C)OC(=S)S[Na]
Show InChI InChI=1S/C4H8OS2.Na/c1-3(2)5-4(6)7;/h3H,1-2H3,(H,6,7);/q;+1/p-1
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9.80E+3 -28.1n/an/an/an/an/a6.820



University of Tehran



Assay Description
Kinetic assay of catecholase and cresolase activities was carried out through depletion of MeBACat and MePAPh for 1 or 2 min with enzyme concentratio...


J Enzyme Inhib Med Chem 22: 239-46 (2007)


Article DOI: 10.1080/14756360601114536
BindingDB Entry DOI: 10.7270/Q2XS5SZW
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM86062
PNG
(Iso-propyl xanthate, I)
Show SMILES CC(C)OC(=S)S[Na]
Show InChI InChI=1S/C4H8OS2.Na/c1-3(2)5-4(6)7;/h3H,1-2H3,(H,6,7);/q;+1/p-1
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1.29E+4 -27.4n/an/an/an/an/a6.820



University of Tehran



Assay Description
Kinetic assay of catecholase and cresolase activities was carried out through depletion of MeBACat and MePAPh for 1 or 2 min with enzyme concentratio...


J Enzyme Inhib Med Chem 22: 239-46 (2007)


Article DOI: 10.1080/14756360601114536
BindingDB Entry DOI: 10.7270/Q2XS5SZW
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50382706
PNG
(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Show SMILES [S-]C(=S)NCc1ccccc1
Show InChI InChI=1S/C8H9NS2/c10-8(11)9-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10,11)/p-1
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1.41E+4 -27.9n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM86063
PNG
(Iso-butyl xanthate, II)
Show SMILES CC(C)COC(=S)S[Na]
Show InChI InChI=1S/C5H10OS2.Na/c1-4(2)3-6-5(7)8;/h4H,3H2,1-2H3,(H,7,8);/q;+1/p-1
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2.18E+4 -26.2n/an/an/an/an/a6.820



University of Tehran



Assay Description
Kinetic assay of catecholase and cresolase activities was carried out through depletion of MeBACat and MePAPh for 1 or 2 min with enzyme concentratio...


J Enzyme Inhib Med Chem 22: 239-46 (2007)


Article DOI: 10.1080/14756360601114536
BindingDB Entry DOI: 10.7270/Q2XS5SZW
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM86064
PNG
(Iso-pentyl xanthate, III)
Show SMILES CC(C)CCOC(=S)S[Na]
Show InChI InChI=1S/C6H12OS2.Na/c1-5(2)3-4-7-6(8)9;/h5H,3-4H2,1-2H3,(H,8,9);/q;+1/p-1
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4.22E+4 -24.6n/an/an/an/an/a6.820



University of Tehran



Assay Description
Kinetic assay of catecholase and cresolase activities was carried out through depletion of MeBACat and MePAPh for 1 or 2 min with enzyme concentratio...


J Enzyme Inhib Med Chem 22: 239-46 (2007)


Article DOI: 10.1080/14756360601114536
BindingDB Entry DOI: 10.7270/Q2XS5SZW
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM85774
PNG
(Tyrosinase Inhibitor, 10)
Show SMILES C(CCN1CCC(CC1)N1CCCCC1)COc1ccccc1
Show InChI InChI=1S/C20H32N2O/c1-3-9-20(10-4-1)23-18-8-7-13-21-16-11-19(12-17-21)22-14-5-2-6-15-22/h1,3-4,9-10,19H,2,5-8,11-18H2
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n/an/a 1.95E+4n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.67E+4n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50198715
PNG
((2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)pr...)
Show SMILES N[C@@H](Cn1ccc(=O)c(O)c1)C(O)=O
Show InChI InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
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PubMed
n/an/a 3.68E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM87066
PNG
(2HBA | 3-[(5E)-4-keto-5-p-anisylidene-2-thioxo-thi...)
Show SMILES COc1ccc(\C=C2\SC(=S)N(CCC(O)=O)C2=O)cc1
Show InChI InChI=1S/C14H13NO4S2/c1-19-10-4-2-9(3-5-10)8-11-13(18)15(14(20)21-11)7-6-12(16)17/h2-5,8H,6-7H2,1H3,(H,16,17)/b11-8+
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n/an/a 2.39E+6n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM87065
PNG
(3HBA | 4-[4-(4-methylphenyl)sulfonyl-2-(3,4,5-trim...)
Show SMILES COc1cc(cc(OC)c1OC)-c1nc(c(o1)N1CCOCC1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H26N2O7S/c1-15-5-7-17(8-6-15)33(26,27)22-23(25-9-11-31-12-10-25)32-21(24-22)16-13-18(28-2)20(30-4)19(14-16)29-3/h5-8,13-14H,9-12H2,1-4H3
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n/an/a 9.52E+5n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50177408
PNG
(4-(hydroxymethyl)phenol | 4-Hydroxybenzyl alcohol ...)
Show SMILES OCc1ccc(O)cc1
Show InChI InChI=1S/C7H8O2/c8-5-6-1-3-7(9)4-2-6/h1-4,8-9H,5H2
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n/an/a 6.50E+5n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM26190
PNG
(1,4-Dihydroxybenzene, XIII | 1,4-dihydroxybenzene ...)
Show SMILES Oc1ccc(O)cc1
Show InChI InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
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n/an/a 1.88E+5n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50130191
PNG
(2-Hydroxymethyl-6-(4-hydroxy-phenoxy)-tetrahydro-p...)
Show SMILES OCC1OC(Oc2ccc(O)cc2)C(O)C(O)C1O
Show InChI InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2
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n/an/a 6.25E+5n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM87066
PNG
(2HBA | 3-[(5E)-4-keto-5-p-anisylidene-2-thioxo-thi...)
Show SMILES COc1ccc(\C=C2\SC(=S)N(CCC(O)=O)C2=O)cc1
Show InChI InChI=1S/C14H13NO4S2/c1-19-10-4-2-9(3-5-10)8-11-13(18)15(14(20)21-11)7-6-12(16)17/h2-5,8H,6-7H2,1H3,(H,16,17)/b11-8+
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n/an/a 8.94E+5n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM87065
PNG
(3HBA | 4-[4-(4-methylphenyl)sulfonyl-2-(3,4,5-trim...)
Show SMILES COc1cc(cc(OC)c1OC)-c1nc(c(o1)N1CCOCC1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H26N2O7S/c1-15-5-7-17(8-6-15)33(26,27)22-23(25-9-11-31-12-10-25)32-21(24-22)16-13-18(28-2)20(30-4)19(14-16)29-3/h5-8,13-14H,9-12H2,1-4H3
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n/an/a 4.02E+5n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50177408
PNG
(4-(hydroxymethyl)phenol | 4-Hydroxybenzyl alcohol ...)
Show SMILES OCc1ccc(O)cc1
Show InChI InChI=1S/C7H8O2/c8-5-6-1-3-7(9)4-2-6/h1-4,8-9H,5H2
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n/an/a 3.50E+5n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM26190
PNG
(1,4-Dihydroxybenzene, XIII | 1,4-dihydroxybenzene ...)
Show SMILES Oc1ccc(O)cc1
Show InChI InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
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n/an/a 8.76E+4n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50130191
PNG
(2-Hydroxymethyl-6-(4-hydroxy-phenoxy)-tetrahydro-p...)
Show SMILES OCC1OC(Oc2ccc(O)cc2)C(O)C(O)C1O
Show InChI InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2
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n/an/a 2.96E+5n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


J Enzyme Inhib Med Chem 23: 526-34 (2008)


Article DOI: 10.1080/14756360701654894
BindingDB Entry DOI: 10.7270/Q29885MB
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234390
PNG
(Polyhydroxy benzophenone, 4)
Show SMILES Oc1ccc(C(=O)c2ccc(O)cc2O)c(O)c1
Show InChI InChI=1S/C13H10O5/c14-7-1-3-9(11(16)5-7)13(18)10-4-2-8(15)6-12(10)17/h1-6,14-17H
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n/an/a>2.00E+5n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234391
PNG
(Polyhydroxy benzophenone, 5)
Show SMILES COc1cc(ccc1O)C(=O)c1ccc(O)cc1O
Show InChI InChI=1S/C14H12O5/c1-19-13-6-8(2-5-11(13)16)14(18)10-4-3-9(15)7-12(10)17/h2-7,15-17H,1H3
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Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234392
PNG
(Polyhydroxy benzophenone, 6)
Show SMILES Oc1ccc(C(=O)c2cc(O)c(O)c(O)c2)c(O)c1
Show InChI InChI=1S/C13H10O6/c14-7-1-2-8(9(15)5-7)12(18)6-3-10(16)13(19)11(17)4-6/h1-5,14-17,19H
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n/an/a 1.74E+4n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM225845
PNG
(Polyhydroxy benzophenone, 7 | hsp90_136)
Show SMILES Oc1ccc(cc1)C(=O)c1ccc(O)c(O)c1O
Show InChI InChI=1S/C13H10O5/c14-8-3-1-7(2-4-8)11(16)9-5-6-10(15)13(18)12(9)17/h1-6,14-15,17-18H
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n/an/a>1.00E+5n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM225847
PNG
(Polyhydroxy benzophenone, 8 | hsp90_138)
Show SMILES Oc1ccc(C(=O)c2ccc(O)c(O)c2O)c(O)c1
Show InChI InChI=1S/C13H10O6/c14-6-1-2-7(10(16)5-6)11(17)8-3-4-9(15)13(19)12(8)18/h1-5,14-16,18-19H
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n/an/a 1.01E+4n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234393
PNG
(Polyhydroxy benzophenone, 9)
Show SMILES COc1cc(ccc1O)C(=O)c1ccc(O)c(O)c1O
Show InChI InChI=1S/C14H12O6/c1-20-11-6-7(2-4-9(11)15)12(17)8-3-5-10(16)14(19)13(8)18/h2-6,15-16,18-19H,1H3
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n/an/a 6.40E+3n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234394
PNG
(Polyhydroxy benzophenone, 10)
Show SMILES Oc1ccc(C(=O)c2cc(O)c(O)c(O)c2)c(O)c1O
Show InChI InChI=1S/C13H10O7/c14-7-2-1-6(11(18)13(7)20)10(17)5-3-8(15)12(19)9(16)4-5/h1-4,14-16,18-20H
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n/an/a 1.40E+3n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234395
PNG
(Polyhydroxy benzophenone, 11)
Show SMILES Oc1ccc(C(=O)c2c(O)cc(O)cc2O)c(O)c1
Show InChI InChI=1S/C13H10O6/c14-6-1-2-8(9(16)3-6)13(19)12-10(17)4-7(15)5-11(12)18/h1-5,14-18H
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Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM225876
PNG
(Polyhydroxy benzophenone, 12 | hsp90_175)
Show SMILES Oc1ccc(C(=O)c2cccc(O)c2)c(O)c1
Show InChI InChI=1S/C13H10O4/c14-9-3-1-2-8(6-9)13(17)11-5-4-10(15)7-12(11)16/h1-7,14-16H
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Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50249353
PNG
(1,1,3-trihydroxybenzophenone | 2,2',4-trihydroxybe...)
Show SMILES Oc1ccc(C(=O)c2ccccc2O)c(O)c1
Show InChI InChI=1S/C13H10O4/c14-8-5-6-10(12(16)7-8)13(17)9-3-1-2-4-11(9)15/h1-7,14-16H
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n/an/a 7.30E+3n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234396
PNG
(Polyhydroxy benzophenone, 14)
Show SMILES Oc1ccc(cc1)C(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C13H10O5/c14-9-3-1-7(2-4-9)12(17)8-5-10(15)13(18)11(16)6-8/h1-6,14-16,18H
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n/an/a 9.83E+4n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234397
PNG
(Polyhydroxy benzophenone, 15)
Show SMILES Oc1ccc(C(=O)c2ccccc2O)c(O)c1O
Show InChI InChI=1S/C13H10O5/c14-9-4-2-1-3-7(9)11(16)8-5-6-10(15)13(18)12(8)17/h1-6,14-15,17-18H
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n/an/a 8.80E+3n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234398
PNG
(Polyhydroxy benzophenone, 16)
Show SMILES Oc1cc(O)c(C(=O)c2ccccc2)c(O)c1
Show InChI InChI=1S/C13H10O4/c14-9-6-10(15)12(11(16)7-9)13(17)8-4-2-1-3-5-8/h1-7,14-16H
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Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50234650
PNG
(2,3,4-trihydroxybenzophenone | CHEMBL1527 | Polyhy...)
Show SMILES Oc1ccc(C(=O)c2ccccc2)c(O)c1O
Show InChI InChI=1S/C13H10O4/c14-10-7-6-9(12(16)13(10)17)11(15)8-4-2-1-3-5-8/h1-7,14,16-17H
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n/an/a 1.05E+4n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234399
PNG
(Polyhydroxy benzophenone, 18)
Show SMILES Oc1cccc(C(=O)c2ccccc2)c1O
Show InChI InChI=1S/C13H10O3/c14-11-8-4-7-10(13(11)16)12(15)9-5-2-1-3-6-9/h1-8,14,16H
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Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM241950
PNG
(Neolitsea aciculata extract, 5)
Show SMILES CC1OC(Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)C(OC(=O)\C=C\c2ccc(O)cc2)C(OC(=O)\C=C\c2ccc(O)cc2)C1O
Show InChI InChI=1S/C39H32O14/c1-20-33(47)36(51-30(45)16-6-21-2-10-24(40)11-3-21)38(52-31(46)17-7-22-4-12-25(41)13-5-22)39(49-20)53-37-34(48)32-28(44)18-27(43)19-29(32)50-35(37)23-8-14-26(42)15-9-23/h2-20,33,36,38-44,47H,1H3/b16-6+,17-7+
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n/an/a 6.70E+4n/an/an/an/a6.837



Jeju National University



Assay Description
Briefly, mushroom tyrosinase (1250 units/mL) and 2 mM L-tyrosine (0.07 mL) were added to a solution of phosphate buffer (0.1 M, pH 6.8, 0.09 mL) cont...


J Enzyme Inhib Med Chem 28: 685-9 (2013)


Article DOI: 10.3109/14756366.2012.670806
BindingDB Entry DOI: 10.7270/Q2XS5T9S
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM241951
PNG
(Neolitsea aciculata extract, 6)
Show SMILES CC1OC(Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)C(OC(=O)\C=C\c2ccc(O)cc2)C(O)C1O
Show InChI InChI=1S/C30H26O12/c1-14-24(36)26(38)29(41-22(35)11-4-15-2-7-17(31)8-3-15)30(39-14)42-28-25(37)23-20(34)12-19(33)13-21(23)40-27(28)16-5-9-18(32)10-6-16/h2-14,24,26,29-34,36,38H,1H3/b11-4+
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Jeju National University



Assay Description
Briefly, mushroom tyrosinase (1250 units/mL) and 2 mM L-tyrosine (0.07 mL) were added to a solution of phosphate buffer (0.1 M, pH 6.8, 0.09 mL) cont...


J Enzyme Inhib Med Chem 28: 685-9 (2013)


Article DOI: 10.3109/14756366.2012.670806
BindingDB Entry DOI: 10.7270/Q2XS5T9S
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM85773
PNG
(Tyrosinase Inhibitor, 8)
Show SMILES O=N(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C16H23N3O4S/c20-19(21)15-4-6-16(7-5-15)24(22,23)18-12-8-14(9-13-18)17-10-2-1-3-11-17/h4-7,14H,1-3,8-13H2
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n/an/a 8.76E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218210
PNG
(2,2,2-trifluoro-1-(4-(piperidin-1-yl)piperidin-1-y...)
Show SMILES FC(F)(F)C(=O)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C12H19F3N2O/c13-12(14,15)11(18)17-8-4-10(5-9-17)16-6-2-1-3-7-16/h10H,1-9H2
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n/an/a 1.81E+4n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218211
PNG
(1'-(4-Methyl-benzyl)-[1,4']bipiperidinyl | CHEMBL3...)
Show SMILES Cc1ccc(CN2CCC(CC2)N2CCCCC2)cc1
Show InChI InChI=1S/C18H28N2/c1-16-5-7-17(8-6-16)15-19-13-9-18(10-14-19)20-11-3-2-4-12-20/h5-8,18H,2-4,9-15H2,1H3
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n/an/a 1.72E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218209
PNG
(CHEMBL250773 | Tyrosinase Inhibitor, 3 | naphthale...)
Show SMILES O=C(N1CCC(CC1)N1CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C21H26N2O/c24-21(19-9-8-17-6-2-3-7-18(17)16-19)23-14-10-20(11-15-23)22-12-4-1-5-13-22/h2-3,6-9,16,20H,1,4-5,10-15H2
KEGG

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PC sid
UniChem

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Article
PubMed
n/an/a 6.64E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218205
PNG
(1-(4-(piperidin-1-yl)piperidin-1-yl)ethanone | CHE...)
Show SMILES CC(=O)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C12H22N2O/c1-11(15)13-9-5-12(6-10-13)14-7-3-2-4-8-14/h12H,2-10H2,1H3
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 2.99E+4n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218206
PNG
(1,4'-bipiperidine | 1,4'-bipiperidyl | 4-PIPERIDIN...)
Show SMILES C1CCN(CC1)C1CCNCC1
Show InChI InChI=1S/C10H20N2/c1-2-8-12(9-3-1)10-4-6-11-7-5-10/h10-11H,1-9H2
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.11E+5n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
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