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Patent code US9669028

Compile Data Set for Download or QSAR
Found 175 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162026
PNG
(US9669028, 28 N-(1-(3,4-difluorobenzyl)piperidin-3...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(Cl)c(Cl)c4)C3)cc12
Show InChI InChI=1S/C19H21Cl2N5/c1-12-16-8-15(9-22-19(16)25-24-12)23-14-3-2-6-26(11-14)10-13-4-5-17(20)18(21)7-13/h4-5,7-9,14,23H,2-3,6,10-11H2,1H3,(H,22,24,25)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162228
PNG
(US9669028, 51 6-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(C1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C16H19N7/c1-10-13-5-11(6-18-16(13)22-21-10)14-7-17-8-15(20-14)19-12-3-4-23(2)9-12/h5-8,12H,3-4,9H2,1-2H3,(H,19,20)(H,18,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162246
PNG
(US9669028, 68 N1,N1-dimethyl-N2-(6-(3-methyl-1H-py...)
Show SMILES CN(C)CCNc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C15H19N7/c1-10-12-6-11(7-18-15(12)21-20-10)13-8-16-9-14(19-13)17-4-5-22(2)3/h6-9H,4-5H2,1-3H3,(H,17,19)(H,18,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162333
PNG
(US9669028, 87 N-(1-isopropylpiperidin-4-yl)-6-(3-m...)
Show SMILES CC(C)N1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C19H25N7/c1-12(2)26-6-4-15(5-7-26)22-18-11-20-10-17(23-18)14-8-16-13(3)24-25-19(16)21-9-14/h8-12,15H,4-7H2,1-3H3,(H,22,23)(H,21,24,25)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162334
PNG
(US9669028, 90 5-(6-(indolin-1-yl)pyrazin-2-yl)-3-m...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCc2ccccc12
Show InChI InChI=1S/C19H16N6/c1-12-15-8-14(9-21-19(15)24-23-12)16-10-20-11-18(22-16)25-7-6-13-4-2-3-5-17(13)25/h2-5,8-11H,6-7H2,1H3,(H,21,23,24)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162334
PNG
(US9669028, 90 5-(6-(indolin-1-yl)pyrazin-2-yl)-3-m...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCc2ccccc12
Show InChI InChI=1S/C19H16N6/c1-12-15-8-14(9-21-19(15)24-23-12)16-10-20-11-18(22-16)25-7-6-13-4-2-3-5-17(13)25/h2-5,8-11H,6-7H2,1H3,(H,21,23,24)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162346
PNG
(US9669028, 125 5-(6-(4-methylpiperazin-1-yl)pyrazi...)
Show SMILES CN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C16H18N6/c1-21-4-6-22(7-5-21)15-11-17-10-14(20-15)13-8-12-2-3-18-16(12)19-9-13/h2-3,8-11H,4-7H2,1H3,(H,18,19)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162351
PNG
(US9669028, 131 1-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES O=C1CCCN1c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H13N5O/c21-14-2-1-5-20(14)13-9-16-8-12(19-13)11-6-10-3-4-17-15(10)18-7-11/h3-4,6-9H,1-2,5H2,(H,17,18)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162353
PNG
(US9669028, 134 5-(6-(indolin-1-yl)pyrazin-2-yl)-1H...)
Show SMILES C1Cc2ccccc2N1c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C19H15N5/c1-2-4-17-13(3-1)6-8-24(17)18-12-20-11-16(23-18)15-9-14-5-7-21-19(14)22-10-15/h1-5,7,9-12H,6,8H2,(H,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162354
PNG
(US9669028, 135 5-(6-(3,3-difluoropyrrolidin-1-yl)p...)
Show SMILES FC1(F)CCN(C1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H13F2N5/c16-15(17)2-4-22(9-15)13-8-18-7-12(21-13)11-5-10-1-3-19-14(10)20-6-11/h1,3,5-8H,2,4,9H2,(H,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162356
PNG
(US9669028, 138 (6-(1H-pyrrolo[2,3-b]pyridin-5-yl)p...)
Show SMILES O=C(N1CCCCC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H17N5O/c23-17(22-6-2-1-3-7-22)15-11-18-10-14(21-15)13-8-12-4-5-19-16(12)20-9-13/h4-5,8-11H,1-3,6-7H2,(H,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162358
PNG
(US9669028, 140 N-(1-methylpiperidin-4-yl)-6-(1H-py...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H20N6/c1-23-6-3-14(4-7-23)21-16-11-18-10-15(22-16)13-8-12-2-5-19-17(12)20-9-13/h2,5,8-11,14H,3-4,6-7H2,1H3,(H,19,20)(H,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162361
PNG
(US9669028, 143 N-methyl-6-(1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C18H21N5O/c1-23(12-13-3-6-24-7-4-13)17-11-19-10-16(22-17)15-8-14-2-5-20-18(14)21-9-15/h2,5,8-11,13H,3-4,6-7,12H2,1H3,(H,20,21)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164197
PNG
(US9669028, 150 4-(6-(3-fluoro-1H-pyrrolo[2,3-b]pyr...)
Show SMILES Fc1c[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1
Show InChI InChI=1S/C15H14FN5O/c16-12-7-19-15-11(12)5-10(6-18-15)13-8-17-9-14(20-13)21-1-3-22-4-2-21/h5-9H,1-4H2,(H,18,19)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164198
PNG
(US9669028, 152 5-(3-((4-methylpiperazin-1-yl)methy...)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cnc3[nH]ccc3c2)CC1
Show InChI InChI=1S/C19H22N4/c1-22-7-9-23(10-8-22)14-15-3-2-4-16(11-15)18-12-17-5-6-20-19(17)21-13-18/h2-6,11-13H,7-10,14H2,1H3,(H,20,21)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM161987
PNG
(US9669028, 13 6-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C17H21N7/c1-11-14-7-12(8-19-17(14)23-22-11)15-9-18-10-16(21-15)20-13-3-5-24(2)6-4-13/h7-10,13H,3-6H2,1-2H3,(H,20,21)(H,19,22,23)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162018
PNG
(US9669028, 22 N-(1-(4-fluorobenzyl)piperidin-3-yl)...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(F)cc4)C3)cc12
Show InChI InChI=1S/C19H22FN5/c1-13-18-9-17(10-21-19(18)24-23-13)22-16-3-2-8-25(12-16)11-14-4-6-15(20)7-5-14/h4-7,9-10,16,22H,2-3,8,11-12H2,1H3,(H,21,23,24)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162020
PNG
(US9669028, 27 N-(1-(4-chlorobenzyl)piperidin-3-yl)...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(Cl)cc4)C3)cc12
Show InChI InChI=1S/C19H22ClN5/c1-13-18-9-17(10-21-19(18)24-23-13)22-16-3-2-8-25(12-16)11-14-4-6-15(20)7-5-14/h4-7,9-10,16,22H,2-3,8,11-12H2,1H3,(H,21,23,24)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162026
PNG
(US9669028, 28 N-(1-(3,4-difluorobenzyl)piperidin-3...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(Cl)c(Cl)c4)C3)cc12
Show InChI InChI=1S/C19H21Cl2N5/c1-12-16-8-15(9-22-19(16)25-24-12)23-14-3-2-6-26(11-14)10-13-4-5-17(20)18(21)7-13/h4-5,7-9,14,23H,2-3,6,10-11H2,1H3,(H,22,24,25)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162035
PNG
(US9669028, 39 1-methyl-N-(6-(3-methyl-1H-pyrazolo[...)
Show SMILES CN1CCC(CC1)C(=O)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H21N7O/c1-11-14-7-13(8-20-17(14)24-23-11)15-9-19-10-16(21-15)22-18(26)12-3-5-25(2)6-4-12/h7-10,12H,3-6H2,1-2H3,(H,20,23,24)(H,21,22,26)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162328
PNG
(US9669028, 77 (6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)C(=O)N1CCCCC1
Show InChI InChI=1S/C17H18N6O/c1-11-13-7-12(8-19-16(13)22-21-11)14-9-18-10-15(20-14)17(24)23-5-3-2-4-6-23/h7-10H,2-6H2,1H3,(H,19,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162334
PNG
(US9669028, 90 5-(6-(indolin-1-yl)pyrazin-2-yl)-3-m...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCc2ccccc12
Show InChI InChI=1S/C19H16N6/c1-12-15-8-14(9-21-19(15)24-23-12)16-10-20-11-18(22-16)25-7-6-13-4-2-3-5-17(13)25/h2-5,8-11H,6-7H2,1H3,(H,21,23,24)
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n/an/a<500n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162338
PNG
(US9669028, 105 4-(6-(3-methyl-1H-pyrazolo[3,4-b]py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1
Show InChI InChI=1S/C15H16N6O/c1-10-12-6-11(7-17-15(12)20-19-10)13-8-16-9-14(18-13)21-2-4-22-5-3-21/h6-9H,2-5H2,1H3,(H,17,19,20)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162349
PNG
(US9669028, 128 5-(3-(pyrrolidin-1-yl)pyrazin-2-yl)...)
Show SMILES C1CCN(C1)c1nccnc1-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H15N5/c1-2-8-20(7-1)15-13(16-5-6-18-15)12-9-11-3-4-17-14(11)19-10-12/h3-6,9-10H,1-2,7-8H2,(H,17,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162351
PNG
(US9669028, 131 1-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES O=C1CCCN1c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H13N5O/c21-14-2-1-5-20(14)13-9-16-8-12(19-13)11-6-10-3-4-17-15(10)18-7-11/h3-4,6-9H,1-2,5H2,(H,17,18)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162351
PNG
(US9669028, 131 1-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES O=C1CCCN1c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H13N5O/c21-14-2-1-5-20(14)13-9-16-8-12(19-13)11-6-10-3-4-17-15(10)18-7-11/h3-4,6-9H,1-2,5H2,(H,17,18)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162355
PNG
(US9669028, 137 1-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES OC1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C16H17N5O/c22-13-2-5-21(6-3-13)15-10-17-9-14(20-15)12-7-11-1-4-18-16(11)19-8-12/h1,4,7-10,13,22H,2-3,5-6H2,(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162362
PNG
(US9669028, 144 6-(3-chloro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C18H20ClN5O/c1-24(11-12-2-4-25-5-3-12)17-10-20-9-16(23-17)13-6-14-15(19)8-22-18(14)21-7-13/h6-10,12H,2-5,11H2,1H3,(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM164048
PNG
(US9669028, 149 4-(6-(3-chloro-1H-pyrrolo[2,3-b]pyr...)
Show SMILES Clc1c[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1
Show InChI InChI=1S/C15H14ClN5O/c16-12-7-19-15-11(12)5-10(6-18-15)13-8-17-9-14(20-13)21-1-3-22-4-2-21/h5-9H,1-4H2,(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164198
PNG
(US9669028, 152 5-(3-((4-methylpiperazin-1-yl)methy...)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cnc3[nH]ccc3c2)CC1
Show InChI InChI=1S/C19H22N4/c1-22-7-9-23(10-8-22)14-15-3-2-4-16(11-15)18-12-17-5-6-20-19(17)21-13-18/h2-6,11-13H,7-10,14H2,1H3,(H,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM161987
PNG
(US9669028, 13 6-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C17H21N7/c1-11-14-7-12(8-19-17(14)23-22-11)15-9-18-10-16(21-15)20-13-3-5-24(2)6-4-13/h7-10,13H,3-6H2,1-2H3,(H,20,21)(H,19,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162019
PNG
(US9669028, 26 N-(1-(3,4-difluorobenzylpiperidin-3-...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(F)c(F)c4)C3)cc12
Show InChI InChI=1S/C19H21F2N5/c1-12-16-8-15(9-22-19(16)25-24-12)23-14-3-2-6-26(11-14)10-13-4-5-17(20)18(21)7-13/h4-5,7-9,14,23H,2-3,6,10-11H2,1H3,(H,22,24,25)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162034
PNG
(US9669028, 33 3-methyl-5-(6-(2-(4-methylpiperazin-...)
Show SMILES CN1CCN(CCOc2cncc(n2)-c2cnc3[nH]nc(C)c3c2)CC1
Show InChI InChI=1S/C18H23N7O/c1-13-15-9-14(10-20-18(15)23-22-13)16-11-19-12-17(21-16)26-8-7-25-5-3-24(2)4-6-25/h9-12H,3-8H2,1-2H3,(H,20,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162045
PNG
(US9669028, 48 1-(6-(3-methyl-1H-pyrazolo[3,4-b]pyr...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCCC1=O
Show InChI InChI=1S/C15H14N6O/c1-9-11-5-10(6-17-15(11)20-19-9)12-7-16-8-13(18-12)21-4-2-3-14(21)22/h5-8H,2-4H2,1H3,(H,17,19,20)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162229
PNG
(US9669028, 56 5-(6-(3,3-difluoropyrrolidin-1-yl)py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCC(F)(F)C1
Show InChI InChI=1S/C15H14F2N6/c1-9-11-4-10(5-19-14(11)22-21-9)12-6-18-7-13(20-12)23-3-2-15(16,17)8-23/h4-7H,2-3,8H2,1H3,(H,19,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162230
PNG
(US9669028, 59 2-(4-(6-(3-methyl-1H-pyrazolo[3,4-b]...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C17H21N7O/c1-12-14-8-13(9-19-17(14)22-21-12)15-10-18-11-16(20-15)24-4-2-23(3-5-24)6-7-25/h8-11,25H,2-7H2,1H3,(H,19,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162232
PNG
(US9669028, 62 (6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)C(=O)N1CCNCC1
Show InChI InChI=1S/C16H17N7O/c1-10-12-6-11(7-19-15(12)22-21-10)13-8-18-9-14(20-13)16(24)23-4-2-17-3-5-23/h6-9,17H,2-5H2,1H3,(H,19,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162233
PNG
(US9669028, 65 3-methyl-5-(6-(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C16H19N7/c1-11-13-7-12(8-18-16(13)21-20-11)14-9-17-10-15(19-14)23-5-3-22(2)4-6-23/h7-10H,3-6H2,1-2H3,(H,18,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162331
PNG
(US9669028, 81 2-(4-((6-(3-methyl-1H-pyrazolo[3,4-b...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(NC2CCN(CCO)CC2)n1
Show InChI InChI=1S/C18H23N7O/c1-12-15-8-13(9-20-18(15)24-23-12)16-10-19-11-17(22-16)21-14-2-4-25(5-3-14)6-7-26/h8-11,14,26H,2-7H2,1H3,(H,21,22)(H,20,23,24)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162338
PNG
(US9669028, 105 4-(6-(3-methyl-1H-pyrazolo[3,4-b]py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1
Show InChI InChI=1S/C15H16N6O/c1-10-12-6-11(7-17-15(12)20-19-10)13-8-16-9-14(18-13)21-2-4-22-5-3-21/h6-9H,2-5H2,1H3,(H,17,19,20)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162346
PNG
(US9669028, 125 5-(6-(4-methylpiperazin-1-yl)pyrazi...)
Show SMILES CN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C16H18N6/c1-21-4-6-22(7-5-21)15-11-17-10-14(20-15)13-8-12-2-3-18-16(12)19-9-13/h2-3,8-11H,4-7H2,1H3,(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162350
PNG
(US9669028, 130 N-(1-methylazetidin-3-yl)-6-(1H-pyr...)
Show SMILES CN1CC(C1)Nc1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H16N6/c1-21-8-12(9-21)19-14-7-16-6-13(20-14)11-4-10-2-3-17-15(10)18-5-11/h2-7,12H,8-9H2,1H3,(H,17,18)(H,19,20)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162353
PNG
(US9669028, 134 5-(6-(indolin-1-yl)pyrazin-2-yl)-1H...)
Show SMILES C1Cc2ccccc2N1c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C19H15N5/c1-2-4-17-13(3-1)6-8-24(17)18-12-20-11-16(23-18)15-9-14-5-7-21-19(14)22-10-15/h1-5,7,9-12H,6,8H2,(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162360
PNG
(US9669028, 142 6-(3-fluoro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]cc(F)c2c1
Show InChI InChI=1S/C17H19FN6/c1-24-4-2-12(3-5-24)22-16-10-19-9-15(23-16)11-6-13-14(18)8-21-17(13)20-7-11/h6-10,12H,2-5H2,1H3,(H,20,21)(H,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162362
PNG
(US9669028, 144 6-(3-chloro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C18H20ClN5O/c1-24(11-12-2-4-25-5-3-12)17-10-20-9-16(23-17)13-6-14-15(19)8-22-18(14)21-7-13/h6-10,12H,2-5,11H2,1H3,(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM163579
PNG
(US9669028, 148 4-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES C1CN(CCO1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H15N5O/c1-2-17-15-11(1)7-12(8-18-15)13-9-16-10-14(19-13)20-3-5-21-6-4-20/h1-2,7-10H,3-6H2,(H,17,18)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164048
PNG
(US9669028, 149 4-(6-(3-chloro-1H-pyrrolo[2,3-b]pyr...)
Show SMILES Clc1c[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1
Show InChI InChI=1S/C15H14ClN5O/c16-12-7-19-15-11(12)5-10(6-18-15)13-8-17-9-14(20-13)21-1-3-22-4-2-21/h5-9H,1-4H2,(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164197
PNG
(US9669028, 150 4-(6-(3-fluoro-1H-pyrrolo[2,3-b]pyr...)
Show SMILES Fc1c[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1
Show InChI InChI=1S/C15H14FN5O/c16-12-7-19-15-11(12)5-10(6-18-15)13-8-17-9-14(20-13)21-1-3-22-4-2-21/h5-9H,1-4H2,(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM164197
PNG
(US9669028, 150 4-(6-(3-fluoro-1H-pyrrolo[2,3-b]pyr...)
Show SMILES Fc1c[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1
Show InChI InChI=1S/C15H14FN5O/c16-12-7-19-15-11(12)5-10(6-18-15)13-8-17-9-14(20-13)21-1-3-22-4-2-21/h5-9H,1-4H2,(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162035
PNG
(US9669028, 39 1-methyl-N-(6-(3-methyl-1H-pyrazolo[...)
Show SMILES CN1CCC(CC1)C(=O)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H21N7O/c1-11-14-7-13(8-20-17(14)24-23-11)15-9-19-10-16(21-15)22-18(26)12-3-5-25(2)6-4-12/h7-10,12H,3-6H2,1-2H3,(H,20,23,24)(H,21,22,26)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162233
PNG
(US9669028, 65 3-methyl-5-(6-(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C16H19N7/c1-11-13-7-12(8-18-16(13)21-20-11)14-9-17-10-15(19-14)23-5-3-22(2)4-6-23/h7-10H,3-6H2,1-2H3,(H,18,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162335
PNG
(US9669028, 94 1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(Nc2cccc(c2)N2CCCC2=O)n1
Show InChI InChI=1S/C21H19N7O/c1-13-17-8-14(10-23-21(17)27-26-13)18-11-22-12-19(25-18)24-15-4-2-5-16(9-15)28-7-3-6-20(28)29/h2,4-5,8-12H,3,6-7H2,1H3,(H,24,25)(H,23,26,27)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162348
PNG
(US9669028, 127 N1-(6-(1H-pyrrolo[2,3-b]pyridin-5-y...)
Show SMILES CN(C)CCNc1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H18N6/c1-21(2)6-5-17-14-10-16-9-13(20-14)12-7-11-3-4-18-15(11)19-8-12/h3-4,7-10H,5-6H2,1-2H3,(H,17,20)(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162348
PNG
(US9669028, 127 N1-(6-(1H-pyrrolo[2,3-b]pyridin-5-y...)
Show SMILES CN(C)CCNc1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H18N6/c1-21(2)6-5-17-14-10-16-9-13(20-14)12-7-11-3-4-18-15(11)19-8-12/h3-4,7-10H,5-6H2,1-2H3,(H,17,20)(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162352
PNG
(US9669028, 133 4-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES O=C1CN(CCN1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H14N6O/c22-14-9-21(4-3-17-14)13-8-16-7-12(20-13)11-5-10-1-2-18-15(10)19-6-11/h1-2,5-8H,3-4,9H2,(H,17,22)(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162354
PNG
(US9669028, 135 5-(6-(3,3-difluoropyrrolidin-1-yl)p...)
Show SMILES FC1(F)CCN(C1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H13F2N5/c16-15(17)2-4-22(9-15)13-8-18-7-12(21-13)11-5-10-1-3-19-14(10)20-6-11/h1,3,5-8H,2,4,9H2,(H,19,20)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162355
PNG
(US9669028, 137 1-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES OC1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C16H17N5O/c22-13-2-5-21(6-3-13)15-10-17-9-14(20-15)12-7-11-1-4-18-16(11)19-8-12/h1,4,7-10,13,22H,2-3,5-6H2,(H,18,19)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162360
PNG
(US9669028, 142 6-(3-fluoro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]cc(F)c2c1
Show InChI InChI=1S/C17H19FN6/c1-24-4-2-12(3-5-24)22-16-10-19-9-15(23-16)11-6-13-14(18)8-21-17(13)20-7-11/h6-10,12H,2-5H2,1H3,(H,20,21)(H,22,23)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162362
PNG
(US9669028, 144 6-(3-chloro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C18H20ClN5O/c1-24(11-12-2-4-25-5-3-12)17-10-20-9-16(23-17)13-6-14-15(19)8-22-18(14)21-7-13/h6-10,12H,2-5,11H2,1H3,(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM163551
PNG
(US9669028, 145 6-(3-fluoro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]cc(F)c2c1
Show InChI InChI=1S/C18H20FN5O/c1-24(11-12-2-4-25-5-3-12)17-10-20-9-16(23-17)13-6-14-15(19)8-22-18(14)21-7-13/h6-10,12H,2-5,11H2,1H3,(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM163551
PNG
(US9669028, 145 6-(3-fluoro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]cc(F)c2c1
Show InChI InChI=1S/C18H20FN5O/c1-24(11-12-2-4-25-5-3-12)17-10-20-9-16(23-17)13-6-14-15(19)8-22-18(14)21-7-13/h6-10,12H,2-5,11H2,1H3,(H,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM163579
PNG
(US9669028, 148 4-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES C1CN(CCO1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H15N5O/c1-2-17-15-11(1)7-12(8-18-15)13-9-16-10-14(19-13)20-3-5-21-6-4-20/h1-2,7-10H,3-6H2,(H,17,18)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164048
PNG
(US9669028, 149 4-(6-(3-chloro-1H-pyrrolo[2,3-b]pyr...)
Show SMILES Clc1c[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1
Show InChI InChI=1S/C15H14ClN5O/c16-12-7-19-15-11(12)5-10(6-18-15)13-8-17-9-14(20-13)21-1-3-22-4-2-21/h5-9H,1-4H2,(H,18,19)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM161988
PNG
(US9669028, 19 5-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1ncncc1-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C17H21N7/c1-11-14-7-12(8-19-17(14)23-22-11)15-9-18-10-20-16(15)21-13-3-5-24(2)6-4-13/h7-10,13H,3-6H2,1-2H3,(H,18,20,21)(H,19,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM161988
PNG
(US9669028, 19 5-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1ncncc1-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C17H21N7/c1-11-14-7-12(8-19-17(14)23-22-11)15-9-18-10-20-16(15)21-13-3-5-24(2)6-4-13/h7-10,13H,3-6H2,1-2H3,(H,18,20,21)(H,19,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162018
PNG
(US9669028, 22 N-(1-(4-fluorobenzyl)piperidin-3-yl)...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(F)cc4)C3)cc12
Show InChI InChI=1S/C19H22FN5/c1-13-18-9-17(10-21-19(18)24-23-13)22-16-3-2-8-25(12-16)11-14-4-6-15(20)7-5-14/h4-7,9-10,16,22H,2-3,8,11-12H2,1H3,(H,21,23,24)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162228
PNG
(US9669028, 51 6-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(C1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C16H19N7/c1-10-13-5-11(6-18-16(13)22-21-10)14-7-17-8-15(20-14)19-12-3-4-23(2)9-12/h5-8,12H,3-4,9H2,1-2H3,(H,19,20)(H,18,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162232
PNG
(US9669028, 62 (6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)C(=O)N1CCNCC1
Show InChI InChI=1S/C16H17N7O/c1-10-12-6-11(7-19-15(12)22-21-10)13-8-18-9-14(20-13)16(24)23-4-2-17-3-5-23/h6-9,17H,2-5H2,1H3,(H,19,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162250
PNG
(US9669028, 71 N-methyl-6-(3-methyl-1H-pyrazolo[3,4...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H22N6O/c1-12-15-7-14(8-20-18(15)23-22-12)16-9-19-10-17(21-16)24(2)11-13-3-5-25-6-4-13/h7-10,13H,3-6,11H2,1-2H3,(H,20,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162250
PNG
(US9669028, 71 N-methyl-6-(3-methyl-1H-pyrazolo[3,4...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H22N6O/c1-12-15-7-14(8-20-18(15)23-22-12)16-9-19-10-17(21-16)24(2)11-13-3-5-25-6-4-13/h7-10,13H,3-6,11H2,1-2H3,(H,20,22,23)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162332
PNG
(US9669028, 83 4-(6-(3-methyl-1H-pyrazolo[3,4-b]pyr...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCNC(=O)C1
Show InChI InChI=1S/C15H15N7O/c1-9-11-4-10(5-18-15(11)21-20-9)12-6-16-7-13(19-12)22-3-2-17-14(23)8-22/h4-7H,2-3,8H2,1H3,(H,17,23)(H,18,20,21)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162332
PNG
(US9669028, 83 4-(6-(3-methyl-1H-pyrazolo[3,4-b]pyr...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCNC(=O)C1
Show InChI InChI=1S/C15H15N7O/c1-9-11-4-10(5-18-15(11)21-20-9)12-6-16-7-13(19-12)22-3-2-17-14(23)8-22/h4-7H,2-3,8H2,1H3,(H,17,23)(H,18,20,21)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162338
PNG
(US9669028, 105 4-(6-(3-methyl-1H-pyrazolo[3,4-b]py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1
Show InChI InChI=1S/C15H16N6O/c1-10-12-6-11(7-17-15(12)20-19-10)13-8-16-9-14(18-13)21-2-4-22-5-3-21/h6-9H,2-5H2,1H3,(H,17,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162340
PNG
(US9669028, 108 3-methyl-5-(1-methyl-1H-pyrazol-4-y...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C11H11N5/c1-7-10-3-8(4-12-11(10)15-14-7)9-5-13-16(2)6-9/h3-6H,1-2H3,(H,12,14,15)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162346
PNG
(US9669028, 125 5-(6-(4-methylpiperazin-1-yl)pyrazi...)
Show SMILES CN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C16H18N6/c1-21-4-6-22(7-5-21)15-11-17-10-14(20-15)13-8-12-2-3-18-16(12)19-9-13/h2-3,8-11H,4-7H2,1H3,(H,18,19)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162353
PNG
(US9669028, 134 5-(6-(indolin-1-yl)pyrazin-2-yl)-1H...)
Show SMILES C1Cc2ccccc2N1c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C19H15N5/c1-2-4-17-13(3-1)6-8-24(17)18-12-20-11-16(23-18)15-9-14-5-7-21-19(14)22-10-15/h1-5,7,9-12H,6,8H2,(H,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162358
PNG
(US9669028, 140 N-(1-methylpiperidin-4-yl)-6-(1H-py...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H20N6/c1-23-6-3-14(4-7-23)21-16-11-18-10-15(22-16)13-8-12-2-5-19-17(12)20-9-13/h2,5,8-11,14H,3-4,6-7H2,1H3,(H,19,20)(H,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162359
PNG
(US9669028, 141 6-(3-chloro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C17H19ClN6/c1-24-4-2-12(3-5-24)22-16-10-19-9-15(23-16)11-6-13-14(18)8-21-17(13)20-7-11/h6-10,12H,2-5H2,1H3,(H,20,21)(H,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162361
PNG
(US9669028, 143 N-methyl-6-(1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C18H21N5O/c1-23(12-13-3-6-24-7-4-13)17-11-19-10-16(22-17)15-8-14-2-5-20-18(14)21-9-15/h2,5,8-11,13H,3-4,6-7,12H2,1H3,(H,20,21)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164236
PNG
(US9669028, 184 5-(furan-3-yl)-3-(2-methoxyphenyl)-...)
Show SMILES COc1ccccc1-c1n[nH]c2ncc(cc12)-c1ccoc1
Show InChI InChI=1S/C17H13N3O2/c1-21-15-5-3-2-4-13(15)16-14-8-12(11-6-7-22-10-11)9-18-17(14)20-19-16/h2-10H,1H3,(H,18,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164236
PNG
(US9669028, 184 5-(furan-3-yl)-3-(2-methoxyphenyl)-...)
Show SMILES COc1ccccc1-c1n[nH]c2ncc(cc12)-c1ccoc1
Show InChI InChI=1S/C17H13N3O2/c1-21-15-5-3-2-4-13(15)16-14-8-12(11-6-7-22-10-11)9-18-17(14)20-19-16/h2-10H,1H3,(H,18,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM164236
PNG
(US9669028, 184 5-(furan-3-yl)-3-(2-methoxyphenyl)-...)
Show SMILES COc1ccccc1-c1n[nH]c2ncc(cc12)-c1ccoc1
Show InChI InChI=1S/C17H13N3O2/c1-21-15-5-3-2-4-13(15)16-14-8-12(11-6-7-22-10-11)9-18-17(14)20-19-16/h2-10H,1H3,(H,18,19,20)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM161987
PNG
(US9669028, 13 6-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C17H21N7/c1-11-14-7-12(8-19-17(14)23-22-11)15-9-18-10-16(21-15)20-13-3-5-24(2)6-4-13/h7-10,13H,3-6H2,1-2H3,(H,20,21)(H,19,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM161987
PNG
(US9669028, 13 6-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C17H21N7/c1-11-14-7-12(8-19-17(14)23-22-11)15-9-18-10-16(21-15)20-13-3-5-24(2)6-4-13/h7-10,13H,3-6H2,1-2H3,(H,20,21)(H,19,22,23)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM161987
PNG
(US9669028, 13 6-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C17H21N7/c1-11-14-7-12(8-19-17(14)23-22-11)15-9-18-10-16(21-15)20-13-3-5-24(2)6-4-13/h7-10,13H,3-6H2,1-2H3,(H,20,21)(H,19,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162019
PNG
(US9669028, 26 N-(1-(3,4-difluorobenzylpiperidin-3-...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(F)c(F)c4)C3)cc12
Show InChI InChI=1S/C19H21F2N5/c1-12-16-8-15(9-22-19(16)25-24-12)23-14-3-2-6-26(11-14)10-13-4-5-17(20)18(21)7-13/h4-5,7-9,14,23H,2-3,6,10-11H2,1H3,(H,22,24,25)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162026
PNG
(US9669028, 28 N-(1-(3,4-difluorobenzyl)piperidin-3...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(Cl)c(Cl)c4)C3)cc12
Show InChI InChI=1S/C19H21Cl2N5/c1-12-16-8-15(9-22-19(16)25-24-12)23-14-3-2-6-26(11-14)10-13-4-5-17(20)18(21)7-13/h4-5,7-9,14,23H,2-3,6,10-11H2,1H3,(H,22,24,25)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162035
PNG
(US9669028, 39 1-methyl-N-(6-(3-methyl-1H-pyrazolo[...)
Show SMILES CN1CCC(CC1)C(=O)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H21N7O/c1-11-14-7-13(8-20-17(14)24-23-11)15-9-19-10-16(21-15)22-18(26)12-3-5-25(2)6-4-12/h7-10,12H,3-6H2,1-2H3,(H,20,23,24)(H,21,22,26)
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n/an/a>500n/an/an/an/an/an/a



ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162230
PNG
(US9669028, 59 2-(4-(6-(3-methyl-1H-pyrazolo[3,4-b]...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C17H21N7O/c1-12-14-8-13(9-19-17(14)22-21-12)15-10-18-11-16(20-15)24-4-2-23(3-5-24)6-7-25/h8-11,25H,2-7H2,1H3,(H,19,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162230
PNG
(US9669028, 59 2-(4-(6-(3-methyl-1H-pyrazolo[3,4-b]...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C17H21N7O/c1-12-14-8-13(9-19-17(14)22-21-12)15-10-18-11-16(20-15)24-4-2-23(3-5-24)6-7-25/h8-11,25H,2-7H2,1H3,(H,19,21,22)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162331
PNG
(US9669028, 81 2-(4-((6-(3-methyl-1H-pyrazolo[3,4-b...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(NC2CCN(CCO)CC2)n1
Show InChI InChI=1S/C18H23N7O/c1-12-15-8-13(9-20-18(15)24-23-12)16-10-19-11-17(22-16)21-14-2-4-25(5-3-14)6-7-26/h8-11,14,26H,2-7H2,1H3,(H,21,22)(H,20,23,24)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162332
PNG
(US9669028, 83 4-(6-(3-methyl-1H-pyrazolo[3,4-b]pyr...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCNC(=O)C1
Show InChI InChI=1S/C15H15N7O/c1-9-11-4-10(5-18-15(11)21-20-9)12-6-16-7-13(19-12)22-3-2-17-14(23)8-22/h4-7H,2-3,8H2,1H3,(H,17,23)(H,18,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162333
PNG
(US9669028, 87 N-(1-isopropylpiperidin-4-yl)-6-(3-m...)
Show SMILES CC(C)N1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C19H25N7/c1-12(2)26-6-4-15(5-7-26)22-18-11-20-10-17(23-18)14-8-16-13(3)24-25-19(16)21-9-14/h8-12,15H,4-7H2,1-3H3,(H,22,23)(H,21,24,25)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162335
PNG
(US9669028, 94 1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(Nc2cccc(c2)N2CCCC2=O)n1
Show InChI InChI=1S/C21H19N7O/c1-13-17-8-14(10-23-21(17)27-26-13)18-11-22-12-19(25-18)24-15-4-2-5-16(9-15)28-7-3-6-20(28)29/h2,4-5,8-12H,3,6-7H2,1H3,(H,24,25)(H,23,26,27)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162337
PNG
(US9669028, 102 6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Show SMILES CN1CCC(CC1)Nc1cccc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H22N6/c1-12-15-10-13(11-19-18(15)23-22-12)16-4-3-5-17(21-16)20-14-6-8-24(2)9-7-14/h3-5,10-11,14H,6-9H2,1-2H3,(H,20,21)(H,19,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162340
PNG
(US9669028, 108 3-methyl-5-(1-methyl-1H-pyrazol-4-y...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C11H11N5/c1-7-10-3-8(4-12-11(10)15-14-7)9-5-13-16(2)6-9/h3-6H,1-2H3,(H,12,14,15)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162347
PNG
(US9669028, 126 2-(4-(6-(1H-pyrrolo[2,3-b]pyridin-5...)
Show SMILES OCCN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H20N6O/c24-8-7-22-3-5-23(6-4-22)16-12-18-11-15(21-16)14-9-13-1-2-19-17(13)20-10-14/h1-2,9-12,24H,3-8H2,(H,19,20)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162347
PNG
(US9669028, 126 2-(4-(6-(1H-pyrrolo[2,3-b]pyridin-5...)
Show SMILES OCCN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H20N6O/c24-8-7-22-3-5-23(6-4-22)16-12-18-11-15(21-16)14-9-13-1-2-19-17(13)20-10-14/h1-2,9-12,24H,3-8H2,(H,19,20)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162348
PNG
(US9669028, 127 N1-(6-(1H-pyrrolo[2,3-b]pyridin-5-y...)
Show SMILES CN(C)CCNc1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H18N6/c1-21(2)6-5-17-14-10-16-9-13(20-14)12-7-11-3-4-18-15(11)19-8-12/h3-4,7-10H,5-6H2,1-2H3,(H,17,20)(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162349
PNG
(US9669028, 128 5-(3-(pyrrolidin-1-yl)pyrazin-2-yl)...)
Show SMILES C1CCN(C1)c1nccnc1-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H15N5/c1-2-8-20(7-1)15-13(16-5-6-18-15)12-9-11-3-4-17-14(11)19-10-12/h3-6,9-10H,1-2,7-8H2,(H,17,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162349
PNG
(US9669028, 128 5-(3-(pyrrolidin-1-yl)pyrazin-2-yl)...)
Show SMILES C1CCN(C1)c1nccnc1-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H15N5/c1-2-8-20(7-1)15-13(16-5-6-18-15)12-9-11-3-4-17-14(11)19-10-12/h3-6,9-10H,1-2,7-8H2,(H,17,19)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162350
PNG
(US9669028, 130 N-(1-methylazetidin-3-yl)-6-(1H-pyr...)
Show SMILES CN1CC(C1)Nc1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H16N6/c1-21-8-12(9-21)19-14-7-16-6-13(20-14)11-4-10-2-3-17-15(10)18-5-11/h2-7,12H,8-9H2,1H3,(H,17,18)(H,19,20)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162352
PNG
(US9669028, 133 4-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES O=C1CN(CCN1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H14N6O/c22-14-9-21(4-3-17-14)13-8-16-7-12(20-13)11-5-10-1-2-18-15(10)19-6-11/h1-2,5-8H,3-4,9H2,(H,17,22)(H,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162354
PNG
(US9669028, 135 5-(6-(3,3-difluoropyrrolidin-1-yl)p...)
Show SMILES FC1(F)CCN(C1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H13F2N5/c16-15(17)2-4-22(9-15)13-8-18-7-12(21-13)11-5-10-1-3-19-14(10)20-6-11/h1,3,5-8H,2,4,9H2,(H,19,20)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162359
PNG
(US9669028, 141 6-(3-chloro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]cc(Cl)c2c1
Show InChI InChI=1S/C17H19ClN6/c1-24-4-2-12(3-5-24)22-16-10-19-9-15(23-16)11-6-13-14(18)8-21-17(13)20-7-11/h6-10,12H,2-5H2,1H3,(H,20,21)(H,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162360
PNG
(US9669028, 142 6-(3-fluoro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]cc(F)c2c1
Show InChI InChI=1S/C17H19FN6/c1-24-4-2-12(3-5-24)22-16-10-19-9-15(23-16)11-6-13-14(18)8-21-17(13)20-7-11/h6-10,12H,2-5H2,1H3,(H,20,21)(H,22,23)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM163551
PNG
(US9669028, 145 6-(3-fluoro-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]cc(F)c2c1
Show InChI InChI=1S/C18H20FN5O/c1-24(11-12-2-4-25-5-3-12)17-10-20-9-16(23-17)13-6-14-15(19)8-22-18(14)21-7-13/h6-10,12H,2-5,11H2,1H3,(H,21,22)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM164198
PNG
(US9669028, 152 5-(3-((4-methylpiperazin-1-yl)methy...)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cnc3[nH]ccc3c2)CC1
Show InChI InChI=1S/C19H22N4/c1-22-7-9-23(10-8-22)14-15-3-2-4-16(11-15)18-12-17-5-6-20-19(17)21-13-18/h2-6,11-13H,7-10,14H2,1H3,(H,20,21)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164235
PNG
(US9669028, 183 3-(2-methoxyphenyl)-5-(thiophen-3-y...)
Show SMILES COc1ccccc1-c1n[nH]c2ncc(cc12)-c1ccsc1
Show InChI InChI=1S/C17H13N3OS/c1-21-15-5-3-2-4-13(15)16-14-8-12(11-6-7-22-10-11)9-18-17(14)20-19-16/h2-10H,1H3,(H,18,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM161987
PNG
(US9669028, 13 6-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C17H21N7/c1-11-14-7-12(8-19-17(14)23-22-11)15-9-18-10-16(21-15)20-13-3-5-24(2)6-4-13/h7-10,13H,3-6H2,1-2H3,(H,20,21)(H,19,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162232
PNG
(US9669028, 62 (6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)C(=O)N1CCNCC1
Show InChI InChI=1S/C16H17N7O/c1-10-12-6-11(7-19-15(12)22-21-10)13-8-18-9-14(20-13)16(24)23-4-2-17-3-5-23/h6-9,17H,2-5H2,1H3,(H,19,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162340
PNG
(US9669028, 108 3-methyl-5-(1-methyl-1H-pyrazol-4-y...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C11H11N5/c1-7-10-3-8(4-12-11(10)15-14-7)9-5-13-16(2)6-9/h3-6H,1-2H3,(H,12,14,15)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162347
PNG
(US9669028, 126 2-(4-(6-(1H-pyrrolo[2,3-b]pyridin-5...)
Show SMILES OCCN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H20N6O/c24-8-7-22-3-5-23(6-4-22)16-12-18-11-15(21-16)14-9-13-1-2-19-17(13)20-10-14/h1-2,9-12,24H,3-8H2,(H,19,20)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162356
PNG
(US9669028, 138 (6-(1H-pyrrolo[2,3-b]pyridin-5-yl)p...)
Show SMILES O=C(N1CCCCC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H17N5O/c23-17(22-6-2-1-3-7-22)15-11-18-10-14(21-15)13-8-12-4-5-19-16(12)20-9-13/h4-5,8-11H,1-3,6-7H2,(H,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162361
PNG
(US9669028, 143 N-methyl-6-(1H-pyrrolo[2,3-b]pyridi...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C18H21N5O/c1-23(12-13-3-6-24-7-4-13)17-11-19-10-16(22-17)15-8-14-2-5-20-18(14)21-9-15/h2,5,8-11,13H,3-4,6-7,12H2,1H3,(H,20,21)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM163579
PNG
(US9669028, 148 4-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES C1CN(CCO1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C15H15N5O/c1-2-17-15-11(1)7-12(8-18-15)13-9-16-10-14(19-13)20-3-5-21-6-4-20/h1-2,7-10H,3-6H2,(H,17,18)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164235
PNG
(US9669028, 183 3-(2-methoxyphenyl)-5-(thiophen-3-y...)
Show SMILES COc1ccccc1-c1n[nH]c2ncc(cc12)-c1ccsc1
Show InChI InChI=1S/C17H13N3OS/c1-21-15-5-3-2-4-13(15)16-14-8-12(11-6-7-22-10-11)9-18-17(14)20-19-16/h2-10H,1H3,(H,18,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM164235
PNG
(US9669028, 183 3-(2-methoxyphenyl)-5-(thiophen-3-y...)
Show SMILES COc1ccccc1-c1n[nH]c2ncc(cc12)-c1ccsc1
Show InChI InChI=1S/C17H13N3OS/c1-21-15-5-3-2-4-13(15)16-14-8-12(11-6-7-22-10-11)9-18-17(14)20-19-16/h2-10H,1H3,(H,18,19,20)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162018
PNG
(US9669028, 22 N-(1-(4-fluorobenzyl)piperidin-3-yl)...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(F)cc4)C3)cc12
Show InChI InChI=1S/C19H22FN5/c1-13-18-9-17(10-21-19(18)24-23-13)22-16-3-2-8-25(12-16)11-14-4-6-15(20)7-5-14/h4-7,9-10,16,22H,2-3,8,11-12H2,1H3,(H,21,23,24)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162020
PNG
(US9669028, 27 N-(1-(4-chlorobenzyl)piperidin-3-yl)...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(Cl)cc4)C3)cc12
Show InChI InChI=1S/C19H22ClN5/c1-13-18-9-17(10-21-19(18)24-23-13)22-16-3-2-8-25(12-16)11-14-4-6-15(20)7-5-14/h4-7,9-10,16,22H,2-3,8,11-12H2,1H3,(H,21,23,24)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162020
PNG
(US9669028, 27 N-(1-(4-chlorobenzyl)piperidin-3-yl)...)
Show SMILES Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(Cl)cc4)C3)cc12
Show InChI InChI=1S/C19H22ClN5/c1-13-18-9-17(10-21-19(18)24-23-13)22-16-3-2-8-25(12-16)11-14-4-6-15(20)7-5-14/h4-7,9-10,16,22H,2-3,8,11-12H2,1H3,(H,21,23,24)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162034
PNG
(US9669028, 33 3-methyl-5-(6-(2-(4-methylpiperazin-...)
Show SMILES CN1CCN(CCOc2cncc(n2)-c2cnc3[nH]nc(C)c3c2)CC1
Show InChI InChI=1S/C18H23N7O/c1-13-15-9-14(10-20-18(15)23-22-13)16-11-19-12-17(21-16)26-8-7-25-5-3-24(2)4-6-25/h9-12H,3-8H2,1-2H3,(H,20,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162034
PNG
(US9669028, 33 3-methyl-5-(6-(2-(4-methylpiperazin-...)
Show SMILES CN1CCN(CCOc2cncc(n2)-c2cnc3[nH]nc(C)c3c2)CC1
Show InChI InChI=1S/C18H23N7O/c1-13-15-9-14(10-20-18(15)23-22-13)16-11-19-12-17(21-16)26-8-7-25-5-3-24(2)4-6-25/h9-12H,3-8H2,1-2H3,(H,20,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162045
PNG
(US9669028, 48 1-(6-(3-methyl-1H-pyrazolo[3,4-b]pyr...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCCC1=O
Show InChI InChI=1S/C15H14N6O/c1-9-11-5-10(6-17-15(11)20-19-9)12-7-16-8-13(18-12)21-4-2-3-14(21)22/h5-8H,2-4H2,1H3,(H,17,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162229
PNG
(US9669028, 56 5-(6-(3,3-difluoropyrrolidin-1-yl)py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCC(F)(F)C1
Show InChI InChI=1S/C15H14F2N6/c1-9-11-4-10(5-19-14(11)22-21-9)12-6-18-7-13(20-12)23-3-2-15(16,17)8-23/h4-7H,2-3,8H2,1H3,(H,19,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162246
PNG
(US9669028, 68 N1,N1-dimethyl-N2-(6-(3-methyl-1H-py...)
Show SMILES CN(C)CCNc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C15H19N7/c1-10-12-6-11(7-18-15(12)21-20-10)13-8-16-9-14(19-13)17-4-5-22(2)3/h6-9H,4-5H2,1-3H3,(H,17,19)(H,18,20,21)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162250
PNG
(US9669028, 71 N-methyl-6-(3-methyl-1H-pyrazolo[3,4...)
Show SMILES CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H22N6O/c1-12-15-7-14(8-20-18(15)23-22-12)16-9-19-10-17(21-16)24(2)11-13-3-5-25-6-4-13/h7-10,13H,3-6,11H2,1-2H3,(H,20,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162328
PNG
(US9669028, 77 (6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)C(=O)N1CCCCC1
Show InChI InChI=1S/C17H18N6O/c1-11-13-7-12(8-19-16(13)22-21-11)14-9-18-10-15(20-14)17(24)23-5-3-2-4-6-23/h7-10H,2-6H2,1H3,(H,19,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162331
PNG
(US9669028, 81 2-(4-((6-(3-methyl-1H-pyrazolo[3,4-b...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(NC2CCN(CCO)CC2)n1
Show InChI InChI=1S/C18H23N7O/c1-12-15-8-13(9-20-18(15)24-23-12)16-10-19-11-17(22-16)21-14-2-4-25(5-3-14)6-7-26/h8-11,14,26H,2-7H2,1H3,(H,21,22)(H,20,23,24)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162333
PNG
(US9669028, 87 N-(1-isopropylpiperidin-4-yl)-6-(3-m...)
Show SMILES CC(C)N1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C19H25N7/c1-12(2)26-6-4-15(5-7-26)22-18-11-20-10-17(23-18)14-8-16-13(3)24-25-19(16)21-9-14/h8-12,15H,4-7H2,1-3H3,(H,22,23)(H,21,24,25)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162335
PNG
(US9669028, 94 1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(Nc2cccc(c2)N2CCCC2=O)n1
Show InChI InChI=1S/C21H19N7O/c1-13-17-8-14(10-23-21(17)27-26-13)18-11-22-12-19(25-18)24-15-4-2-5-16(9-15)28-7-3-6-20(28)29/h2,4-5,8-12H,3,6-7H2,1H3,(H,24,25)(H,23,26,27)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162337
PNG
(US9669028, 102 6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Show SMILES CN1CCC(CC1)Nc1cccc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H22N6/c1-12-15-10-13(11-19-18(15)23-22-12)16-4-3-5-17(21-16)20-14-6-8-24(2)9-7-14/h3-5,10-11,14H,6-9H2,1-2H3,(H,20,21)(H,19,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162337
PNG
(US9669028, 102 6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Show SMILES CN1CCC(CC1)Nc1cccc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H22N6/c1-12-15-10-13(11-19-18(15)23-22-12)16-4-3-5-17(21-16)20-14-6-8-24(2)9-7-14/h3-5,10-11,14H,6-9H2,1-2H3,(H,20,21)(H,19,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162355
PNG
(US9669028, 137 1-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl...)
Show SMILES OC1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C16H17N5O/c22-13-2-5-21(6-3-13)15-10-17-9-14(20-15)12-7-11-1-4-18-16(11)19-8-12/h1,4,7-10,13,22H,2-3,5-6H2,(H,18,19)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162039
PNG
(US9669028, 42 5-(6-chloropyrazin-2-yl)-3-methyl-1H...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(Cl)n1
Show InChI InChI=1S/C11H8ClN5/c1-6-8-2-7(3-14-11(8)17-16-6)9-4-13-5-10(12)15-9/h2-5H,1H3,(H,14,16,17)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164214
PNG
(US9669028, 164 2-(4-(3-((3-methyl-1H-pyrazolo[3,4-...)
Show SMILES Cc1n[nH]c2ncc(Nc3cccc(CN4CCN(CCO)CC4)c3)cc12
Show InChI InChI=1S/C20H26N6O/c1-15-19-12-18(13-21-20(19)24-23-15)22-17-4-2-3-16(11-17)14-26-7-5-25(6-8-26)9-10-27/h2-4,11-13,22,27H,5-10,14H2,1H3,(H,21,23,24)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162345
PNG
(US9669028, 123 3-methyl-5-(3-((4-methylpiperazin-1...)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cnc3[nH]nc(C)c3c2)CC1
Show InChI InChI=1S/C19H23N5/c1-14-18-11-17(12-20-19(18)22-21-14)16-5-3-4-15(10-16)13-24-8-6-23(2)7-9-24/h3-5,10-12H,6-9,13H2,1-2H3,(H,20,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162041
PNG
(US9669028, 45 3-methyl-5-(pyrazin-2-yl)-1H-pyrazol...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cnccn1
Show InChI InChI=1S/C11H9N5/c1-7-9-4-8(5-14-11(9)16-15-7)10-6-12-2-3-13-10/h2-6H,1H3,(H,14,15,16)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162228
PNG
(US9669028, 51 6-(3-methyl-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CN1CCC(C1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C16H19N7/c1-10-13-5-11(6-18-16(13)22-21-10)14-7-17-8-15(20-14)19-12-3-4-23(2)9-12/h5-8,12H,3-4,9H2,1-2H3,(H,19,20)(H,18,21,22)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162336
PNG
(US9669028, 98 1-methyl-N-(3-(3-methyl-1H-pyrazolo[...)
Show SMILES CN1CCC(CC1)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C19H23N5/c1-13-18-11-15(12-20-19(18)23-22-13)14-4-3-5-17(10-14)21-16-6-8-24(2)9-7-16/h3-5,10-12,16,21H,6-9H2,1-2H3,(H,20,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162357
PNG
(US9669028, 139 (6-(1H-pyrrolo[2,3-b]pyridin-5-yl)p...)
Show SMILES CN1CCN(CC1)C(=O)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H18N6O/c1-22-4-6-23(7-5-22)17(24)15-11-18-10-14(21-15)13-8-12-2-3-19-16(12)20-9-13/h2-3,8-11H,4-7H2,1H3,(H,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164214
PNG
(US9669028, 164 2-(4-(3-((3-methyl-1H-pyrazolo[3,4-...)
Show SMILES Cc1n[nH]c2ncc(Nc3cccc(CN4CCN(CCO)CC4)c3)cc12
Show InChI InChI=1S/C20H26N6O/c1-15-19-12-18(13-21-20(19)24-23-15)22-17-4-2-3-16(11-17)14-26-7-5-25(6-8-26)9-10-27/h2-4,11-13,22,27H,5-10,14H2,1H3,(H,21,23,24)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162039
PNG
(US9669028, 42 5-(6-chloropyrazin-2-yl)-3-methyl-1H...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(Cl)n1
Show InChI InChI=1S/C11H8ClN5/c1-6-8-2-7(3-14-11(8)17-16-6)9-4-13-5-10(12)15-9/h2-5H,1H3,(H,14,16,17)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162246
PNG
(US9669028, 68 N1,N1-dimethyl-N2-(6-(3-methyl-1H-py...)
Show SMILES CN(C)CCNc1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C15H19N7/c1-10-12-6-11(7-18-15(12)21-20-10)13-8-16-9-14(19-13)17-4-5-22(2)3/h6-9H,4-5H2,1-3H3,(H,17,19)(H,18,20,21)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162328
PNG
(US9669028, 77 (6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)C(=O)N1CCCCC1
Show InChI InChI=1S/C17H18N6O/c1-11-13-7-12(8-19-16(13)22-21-11)14-9-18-10-15(20-14)17(24)23-5-3-2-4-6-23/h7-10H,2-6H2,1H3,(H,19,21,22)
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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162341
PNG
(US9669028, 111 N,N-dimethyl-3-(3-methyl-1H-pyrazol...)
Show SMILES CN(C)S(=O)(=O)c1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C15H16N4O2S/c1-10-14-8-12(9-16-15(14)18-17-10)11-5-4-6-13(7-11)22(20,21)19(2)3/h4-9H,1-3H3,(H,16,17,18)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50441090
PNG
(CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-p...)
Show SMILES CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C15H14N4O/c1-9-14-7-12(8-16-15(14)19-18-9)11-4-3-5-13(6-11)17-10(2)20/h3-8H,1-2H3,(H,17,20)(H,16,18,19)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164205
PNG
(US9669028, 155 N-(3-(3-methyl-1H-pyrazolo[3,4-b]py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C16H14N4O/c1-3-15(21)18-13-6-4-5-11(7-13)12-8-14-10(2)19-20-16(14)17-9-12/h3-9H,1H2,2H3,(H,18,21)(H,17,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164216
PNG
(US9669028, 167 3-methyl-N-(4-((4-methylpiperazin-1...)
Show SMILES CN1CCN(Cc2ccc(Nc3cnc4[nH]nc(C)c4c3)cc2)CC1
Show InChI InChI=1S/C19H24N6/c1-14-18-11-17(12-20-19(18)23-22-14)21-16-5-3-15(4-6-16)13-25-9-7-24(2)8-10-25/h3-6,11-12,21H,7-10,13H2,1-2H3,(H,20,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164216
PNG
(US9669028, 167 3-methyl-N-(4-((4-methylpiperazin-1...)
Show SMILES CN1CCN(Cc2ccc(Nc3cnc4[nH]nc(C)c4c3)cc2)CC1
Show InChI InChI=1S/C19H24N6/c1-14-18-11-17(12-20-19(18)23-22-14)21-16-5-3-15(4-6-16)13-25-9-7-24(2)8-10-25/h3-6,11-12,21H,7-10,13H2,1-2H3,(H,20,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164233
PNG
(US9669028, 170 N-(3-fluoro-4-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cnc3[nH]nc(C)c3c2)cc1F
Show InChI InChI=1S/C18H21FN6/c1-12-15-9-14(11-20-18(15)23-22-12)21-13-3-4-17(16(19)10-13)25-7-5-24(2)6-8-25/h3-4,9-11,21H,5-8H2,1-2H3,(H,20,22,23)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164234
PNG
(US9669028, 171 N-(6-chloropyrazin-2-yl)-3-methyl-1...)
Show SMILES Cc1n[nH]c2ncc(Nc3cncc(Cl)n3)cc12
Show InChI InChI=1S/C11H9ClN6/c1-6-8-2-7(3-14-11(8)18-17-6)15-10-5-13-4-9(12)16-10/h2-5H,1H3,(H,15,16)(H,14,17,18)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162041
PNG
(US9669028, 45 3-methyl-5-(pyrazin-2-yl)-1H-pyrazol...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cnccn1
Show InChI InChI=1S/C11H9N5/c1-7-9-4-8(5-14-11(9)16-15-7)10-6-12-2-3-13-10/h2-6H,1H3,(H,14,15,16)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162327
PNG
(US9669028, 74 3-methyl-5-(3-(pyrrolidin-1-yl)pyraz...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1nccnc1N1CCCC1
Show InChI InChI=1S/C15H16N6/c1-10-12-8-11(9-18-14(12)20-19-10)13-15(17-5-4-16-13)21-6-2-3-7-21/h4-5,8-9H,2-3,6-7H2,1H3,(H,18,19,20)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162344
PNG
(US9669028, 119 ethyl3-(3-methyl-1H-pyrazolo[3,4-b]...)
Show SMILES CCOC(=O)c1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C16H15N3O2/c1-3-21-16(20)12-6-4-5-11(7-12)13-8-14-10(2)18-19-15(14)17-9-13/h4-9H,3H2,1-2H3,(H,17,18,19)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164207
PNG
(US9669028, 161 3-methyl-5-(4-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H21N5/c1-13-17-11-15(12-19-18(17)21-20-13)14-3-5-16(6-4-14)23-9-7-22(2)8-10-23/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,21)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164207
PNG
(US9669028, 161 3-methyl-5-(4-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H21N5/c1-13-17-11-15(12-19-18(17)21-20-13)14-3-5-16(6-4-14)23-9-7-22(2)8-10-23/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,21)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162233
PNG
(US9669028, 65 3-methyl-5-(6-(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C16H19N7/c1-11-13-7-12(8-18-16(13)21-20-11)14-9-17-10-15(19-14)23-5-3-22(2)4-6-23/h7-10H,3-6H2,1-2H3,(H,18,20,21)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162336
PNG
(US9669028, 98 1-methyl-N-(3-(3-methyl-1H-pyrazolo[...)
Show SMILES CN1CCC(CC1)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C19H23N5/c1-13-18-11-15(12-20-19(18)23-22-13)14-4-3-5-17(10-14)21-16-6-8-24(2)9-7-16/h3-5,10-12,16,21H,6-9H2,1-2H3,(H,20,22,23)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162344
PNG
(US9669028, 119 ethyl3-(3-methyl-1H-pyrazolo[3,4-b]...)
Show SMILES CCOC(=O)c1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C16H15N3O2/c1-3-21-16(20)12-6-4-5-11(7-12)13-8-14-10(2)18-19-15(14)17-9-13/h4-9H,3H2,1-2H3,(H,17,18,19)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162357
PNG
(US9669028, 139 (6-(1H-pyrrolo[2,3-b]pyridin-5-yl)p...)
Show SMILES CN1CCN(CC1)C(=O)c1cncc(n1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C17H18N6O/c1-22-4-6-23(7-5-22)17(24)15-11-18-10-14(21-15)13-8-12-2-3-19-16(12)20-9-13/h2-3,8-11H,4-7H2,1H3,(H,19,20)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164206
PNG
(US9669028, 158 2-(3-(3-methyl-1H-pyrazolo[3,4-b]py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cccc(CC#N)c1
Show InChI InChI=1S/C15H12N4/c1-10-14-8-13(9-17-15(14)19-18-10)12-4-2-3-11(7-12)5-6-16/h2-4,7-9H,5H2,1H3,(H,17,18,19)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162327
PNG
(US9669028, 74 3-methyl-5-(3-(pyrrolidin-1-yl)pyraz...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1nccnc1N1CCCC1
Show InChI InChI=1S/C15H16N6/c1-10-12-8-11(9-18-14(12)20-19-10)13-15(17-5-4-16-13)21-6-2-3-7-21/h4-5,8-9H,2-3,6-7H2,1H3,(H,18,19,20)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162343
PNG
(US9669028, 117 5-(1-methyl-1H-pyrazol-4-yl)-1H-pyr...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C10H9N5/c1-15-6-9(5-13-15)7-2-8-4-12-14-10(8)11-3-7/h2-6H,1H3,(H,11,12,14)
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ARRIEN PHARMACEUTICALS LLC

US Patent


Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM162343
PNG
(US9669028, 117 5-(1-methyl-1H-pyrazol-4-yl)-1H-pyr...)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C10H9N5/c1-15-6-9(5-13-15)7-2-8-4-12-14-10(8)11-3-7/h2-6H,1H3,(H,11,12,14)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162229
PNG
(US9669028, 56 5-(6-(3,3-difluoropyrrolidin-1-yl)py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCC(F)(F)C1
Show InChI InChI=1S/C15H14F2N6/c1-9-11-4-10(5-19-14(11)22-21-9)12-6-18-7-13(20-12)23-3-2-15(16,17)8-23/h4-7H,2-3,8H2,1H3,(H,19,21,22)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162336
PNG
(US9669028, 98 1-methyl-N-(3-(3-methyl-1H-pyrazolo[...)
Show SMILES CN1CCC(CC1)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C19H23N5/c1-13-18-11-15(12-20-19(18)23-22-13)14-4-3-5-17(10-14)21-16-6-8-24(2)9-7-16/h3-5,10-12,16,21H,6-9H2,1-2H3,(H,20,22,23)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50441090
PNG
(CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-p...)
Show SMILES CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C15H14N4O/c1-9-14-7-12(8-16-15(14)19-18-9)11-4-3-5-13(6-11)17-10(2)20/h3-8H,1-2H3,(H,17,20)(H,16,18,19)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164205
PNG
(US9669028, 155 N-(3-(3-methyl-1H-pyrazolo[3,4-b]py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C16H14N4O/c1-3-15(21)18-13-6-4-5-11(7-13)12-8-14-10(2)19-20-16(14)17-9-12/h3-9H,1H2,2H3,(H,18,21)(H,17,19,20)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM164233
PNG
(US9669028, 170 N-(3-fluoro-4-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cnc3[nH]nc(C)c3c2)cc1F
Show InChI InChI=1S/C18H21FN6/c1-12-15-9-14(11-20-18(15)23-22-12)21-13-3-4-17(16(19)10-13)25-7-5-24(2)6-8-25/h3-4,9-11,21H,5-8H2,1-2H3,(H,20,22,23)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164234
PNG
(US9669028, 171 N-(6-chloropyrazin-2-yl)-3-methyl-1...)
Show SMILES Cc1n[nH]c2ncc(Nc3cncc(Cl)n3)cc12
Show InChI InChI=1S/C11H9ClN6/c1-6-8-2-7(3-14-11(8)18-17-6)15-10-5-13-4-9(12)16-10/h2-5H,1H3,(H,15,16)(H,14,17,18)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM162045
PNG
(US9669028, 48 1-(6-(3-methyl-1H-pyrazolo[3,4-b]pyr...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCCC1=O
Show InChI InChI=1S/C15H14N6O/c1-9-11-5-10(6-17-15(11)20-19-9)12-7-16-8-13(18-12)21-4-2-3-14(21)22/h5-8H,2-4H2,1H3,(H,17,19,20)
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ARRIEN PHARMACEUTICALS LLC

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Assay Description
The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162345
PNG
(US9669028, 123 3-methyl-5-(3-((4-methylpiperazin-1...)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cnc3[nH]nc(C)c3c2)CC1
Show InChI InChI=1S/C19H23N5/c1-14-18-11-17(12-20-19(18)22-21-14)16-5-3-4-15(10-16)13-24-8-6-23(2)7-9-24/h3-5,10-12H,6-9,13H2,1-2H3,(H,20,21,22)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM164206
PNG
(US9669028, 158 2-(3-(3-methyl-1H-pyrazolo[3,4-b]py...)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1cccc(CC#N)c1
Show InChI InChI=1S/C15H12N4/c1-10-14-8-13(9-17-15(14)19-18-10)12-4-2-3-11(7-12)5-6-16/h2-4,7-9H,5H2,1H3,(H,17,18,19)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM162341
PNG
(US9669028, 111 N,N-dimethyl-3-(3-methyl-1H-pyrazol...)
Show SMILES CN(C)S(=O)(=O)c1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C15H16N4O2S/c1-10-14-8-12(9-16-15(14)18-17-10)11-5-4-6-13(7-11)22(20,21)19(2)3/h4-9H,1-3H3,(H,16,17,18)
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Assay Description
Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%