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Report error Found 30 Enz. Inhib. hit(s) for PDB: 4U16
TargetMuscarinic acetylcholine receptor M3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.135nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M3 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMuscarinic acetylcholine receptor M3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.135nMAssay Description:Displacement of [3H]NMS from human cloned muscarinic M3 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMuscarinic acetylcholine receptor M3(Rat)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.25nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMuscarinic acetylcholine receptor M3(Rat)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.501nMAssay Description:Binding affinity to Muscarinic acetylcholine receptor M3 by measuring its ability to displace [3H]N-methylscopolamine binding in rat submandibulary g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMuscarinic acetylcholine receptor M3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataIC50:  1.10nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS radioligand using membranes from trans...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.751nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.555nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.555nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.564nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.556nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.524nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.438nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.548nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.583nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.553nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.462nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.440nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.470nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  1.11nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  1.15nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  1.02nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.640nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMuscarinic acetylcholine receptor M3(Rat)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50015727(7-(3-Hydroxy-2-phenyl-propionyloxy)-9,9-dimethyl-3...)
Affinity DataKd:  0.440nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M3 in rat submandibular gland was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMuscarinic acetylcholine receptor M3(Rat)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataEC50:  0.0500nMAssay Description:Stimulation of disulfide bond cross-linking formation in rat M3'(3C)-Xa receptor A91C/T549C mutant expressed in african green monkey COS7 cells by sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.493nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.499nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.521nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.484nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMuscarinic acetylcholine receptor M3(Rat)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataEC50:  0.195nMAssay Description:Stimulation of disulfide bond cross-linking formation in rat M3'(3C)-Xa receptor F92C/F550C mutant expressed in african green monkey COS7 cells by sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.403nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)