Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM303023
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
>10000±n/a nM
Citation
 Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Wiles, JA; Phadke, AS Amino compounds for treatment of complement mediated disorders US Patent  US9598446 Publication Date 3/21/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM303023
Synonyms:
(2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1H-indol-1- yl)acetyl)-4-fluoro-N- (2-(4-fluorophenyl)- 4,5,6,7- tetrahydrobenzo[d] thiazol- 7-yl)pyrrolidine- 2-carboxamide | US10660876, Cmpd No. 28 | US9598446, Compound 28
Type:
Small organic molecule
Emp. Form.:
C34H31F2N7O3S
Mol. Mass.:
655.717
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCc3nc(sc23)-c2ccc(F)cc2)c2ccc(Nc3cncnc3)cc12 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;$|
Structure:
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