Reaction Details Report a problem with these data
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Ligand
BDBM164355
Substrate
n/a
Meas. Tech.
PDE10A Inhibition Assay
Temperature
298.15±n/a K
IC50
47±n/a nM
Comments
extracted
Citation
 Püschl, A; Nielsen, J; Kehler, J; Kilburn, JP; Marigo, M; Langgård, M Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors US Patent  US9669029 Publication Date 6/6/2017 
Target
Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Synonyms:
PDE10A | PDE10_HUMAN | PED10A | Phosphodiesterase 10A (PDE10A)
Type:
n/a
Mol. Mass.:
39060.01
Organism:
Homo sapiens (Human)
Description:
Q9Y233[440-779]
Residue:
340
Sequence:
ICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
  
Inhibitor
Name:
BDBM164355
Synonyms:
US9669029, 63 8-Fluoro-2-[2-(1-methyl-4-thiophen-2-yl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine
Type:
Small organic molecule
Emp. Form.:
C16H16FN5S
Mol. Mass.:
329.395
SMILES:
Cn1cc(nc1CCC1=NN2C=CC=C(F)C2N1)-c1cccs1 |c:12,t:9,14|
Structure:
Search PDB for entries with ligand similarity: