Reaction Details Report a problem with these data
Target
Chromatin remodeling regulator CECR2 [424-538]
Ligand
BDBM321472
Substrate
n/a
Meas. Tech.
IC50 Measurements for Inhibitors Using TAF1-BD2 TR-FRET Binding Assay
IC50
900±n/a nM
Citation
 Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent  US10183009 Publication Date 1/22/2019 
Target
Name:
Chromatin remodeling regulator CECR2 [424-538]
Synonyms:
CECR2 | CECR2 (aa 424-538) | CECR2_HUMAN | Cat eye syndrome critical region protein 2 [424-538] | KIAA1740
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13747.10
Organism:
Homo sapiens (Human)
Description:
Q9BXF3[424-538]
Residue:
115
Sequence:
MREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKH
  
Inhibitor
Name:
BDBM321472
Synonyms:
4-[5-(6-acetyl-2,6-diazaspiro[3.3]heptane-2-carbonyl)-2-methoxy-phenyl]-6-[(E)-but-2-enyl]-1H-pyrrolo[2,3-c]pyridin-7-one | US10183009, Example 77
Type:
Small organic molecule
Emp. Form.:
C26H28N4O4
Mol. Mass.:
460.5249
SMILES:
COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)N1CC2(CN(C2)C(C)=O)C1
Structure:
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