Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM324779
Substrate
n/a
Meas. Tech.
TNF induced HEK-Blue assay
IC50
<1000±n/a nM
Citation
 Xiao, H; Dhar, MT; Duan, J; Jiang, B; Tebben, AJ Substituted tricyclic heterocyclic compounds US Patent  US10189840 Publication Date 1/29/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM324779
Synonyms:
2-(4-(8-(2-(Trifluoromethyl)phenyl)-7,8-dihydro-6H-pyrrolo[2′,1′:2,3]imidazo[4,5-b]pyridin-2-yl)phenyl)propan-2-ol | US10189840, Example 25
Type:
Small organic molecule
Emp. Form.:
C25H22F3N3O
Mol. Mass.:
437.4569
SMILES:
CC(C)(O)c1ccc(cc1)-c1ccc2nc3CCC(c4ccccc4C(F)(F)F)n3c2n1 |w:18.19|
Structure:
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